Gnb1 guanine nucleotide binding protein (G protein), beta 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gnb1provided by MGI
Official Full Name: guanine nucleotide binding protein (G protein), beta 1provided by MGI
Primary source: MGI:MGI:95781
See related: Ensembl:ENSMUSG00000029064 AllianceGenome:MGI:95781
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hg2a; Gnb-1
Summary: Predicted to enable several functions, including GTPase binding activity; alkylglycerophosphoethanolamine phosphodiesterase activity; and spectrin binding activity. Acts upstream of or within several processes, including phospholipase C-activating G protein-coupled receptor signaling pathway; retina development in camera-type eye; and sensory perception of taste. Located in photoreceptor outer segment. Part of heterotrimeric G-protein complex. Is active in synapse. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; autosomal dominant intellectual developmental disorder 42; congestive heart failure; and myelodysplastic syndrome. Orthologous to human GNB1 (G protein subunit beta 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Ubiquitous expression in CNS E18 (RPKM 188.2), large intestine adult (RPKM 186.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E2; 4 86.17 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (155575514..155643726)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (155491300..155559269)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G protein subunit beta1 is an important mediator of the late stage of endochondral ossification.
Title: G protein subunit β1 is an important mediator of the late stage of endochondral ossification.
Data show that synaptosome associated protein 25 (SNAP25)Delta3 mutation has a twofold reduction in GTP-binding protein beta/gamma (Gbetagamma) binding.
Title: Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes.
This study indicates that GNB1 negatively regulates NLRP3 inflammasome activation
Title: Cutting Edge: G Protein Subunit β 1 Negatively Regulates NLRP3 Inflammasome Activation.
Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 interact in quiescent platelets; then, Ppp1ca and Plcb3 interact during platelet aggregation; thus, Gnb1 enlists Ppp1ca to modulate G protein-coupled receptor signaling. (Ppp1ca = protein phosphatase 1, catalytic subunit alpha; Gnb1 = guanine nucleotide-binding protein, subunit beta-1; Plcb3 = phospholipase C, subunit beta-3)
Title: The heterotrimeric G protein Gβ(1) interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.
It was concluded that GIRK2, through its dual responsiveness to G protein beta-gamma and Na+, mediates a form of neuronal inhibition that is amplifiable in the setting of excess electrical activity.
Title: Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels.
During corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gbetagamma-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
Title: IGF-1 activates a cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression.
Data indicate that a decrease in the Gbeta1 production in Ggamma1 knockout rods resulted in a significant reduction in proteasomal overload and caused a striking reversal of photoreceptor degeneration.
Title: Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.
ectopically expressed cTalpha 1) forms a heterotrimeric complex with rod Gbeta(1)gamma(1), and substitutes equally for rTalpha in generating photoresponses initiated by either rhodopsin or S-cone opsin
Title: Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.
Results suggest a model in which the Gbetagamma dimer that is released as a result of the dissociation from Galpha(o) upon activation of mGluR6 closes the TRPM1 channel, perhaps via a direct interaction.
Title: G-protein-mediated inhibition of the Trp channel TRPM1 requires the Gβγ dimer.
WDR26 is a novel Gbetagamma-binding protein that is required for the efficacy of Gbetagamma signaling and leukocyte migration
Title: The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1) 1 citation
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:496680 (e-PCR)
- UniSTS:496680

Gnb1 (e-PCR), detects polymorphism
- UniSTS:496680

RH126184 (e-PCR)
- UniSTS:162892

RH127715 (e-PCR)
- UniSTS:211025

RH124831 (e-PCR)
- UniSTS:161653

Gnb1 (e-PCR), detects polymorphism
- UniSTS:143228

AA900898 (e-PCR)
- UniSTS:226203

PMC197251P1 (e-PCR)
- UniSTS:271850

NoName (e-PCR)
- UniSTS:236533

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables GTPase binding	IEA Inferred from Electronic Annotation more info
enables GTPase binding	ISO Inferred from Sequence Orthology more info
enables alkylglycerophosphoethanolamine phosphodiesterase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling receptor complex adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within cardiac muscle cell apoptotic process	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cellular response to hypoxia	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within phospholipase C-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within phototransduction, visible light	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sensory perception of taste	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell body	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
part_of heterotrimeric G-protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of heterotrimeric G-protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of heterotrimeric G-protein complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in myelin sheath	HDA more info	PubMed
located_in photoreceptor inner segment	ISO Inferred from Sequence Orthology more info
located_in photoreceptor outer segment	IDA Inferred from Direct Assay more info	PubMed
located_in photoreceptor outer segment membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Names: guanine nucleotide binding protein, beta 1; heterotrimeric guanine nucleotide-binding protein 2a; transducin beta chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001160016.2 → NP_001153488.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

See identical proteins and their annotated locations for NP_001153488.1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

Consensus CDS

CCDS19030.1

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70, Q3U1B1

Related

ENSMUSP00000030940.8, ENSMUST00000030940.14

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_001160017.2 → NP_001153489.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

See identical proteins and their annotated locations for NP_001153489.1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

Consensus CDS

CCDS19030.1

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70, Q3U1B1

Related

ENSMUSP00000101241.4, ENSMUST00000105616.10

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]
NM_001420967.2 → NP_001407896.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70

Related

ENSMUSP00000135492.2, ENSMUST00000177094.8
NM_001420968.1 → NP_001407897.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70
NM_001420969.1 → NP_001407898.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70
NM_001420970.1 → NP_001407899.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70

Related

ENSMUSP00000135091.2, ENSMUST00000176637.2
NM_001420971.1 → NP_001407900.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70
NM_008142.5 → NP_032168.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

See identical proteins and their annotated locations for NP_032168.1

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

Consensus CDS

CCDS19030.1

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70, Q3U1B1

Related

ENSMUSP00000130123.2, ENSMUST00000165335.8

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]

RNA

NR_185220.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627405, AL670227
NR_185221.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627405, AL670227
NR_185222.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627405, AL670227
NR_185223.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL627405, AL670227

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

155575514..155643726

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017319977.2 → XP_017175466.1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1

UniProtKB/Swiss-Prot

P62874

UniProtKB/TrEMBL

Q3TQ70, Q3U1B1

Conserved Domains (2) summary

cd00200
Location:48 → 340

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:58 → 95

7WD40; WD40 repeat [structural motif]