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    Ccdc33 coiled-coil domain containing 33 [ Mus musculus (house mouse) ]

    Gene ID: 382077, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ccdc33provided by MGI
    Official Full Name
    coiled-coil domain containing 33provided by MGI
    Primary source
    MGI:MGI:1922464
    See related
    Ensembl:ENSMUSG00000037716 AllianceGenome:MGI:1922464
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tzip1; Gm1117; 4930535E21Rik
    Summary
    Located in peroxisome. Is expressed in Harderian gland; brain; male reproductive gland or organ; and tongue. Orthologous to human CCDC33 (coiled-coil domain containing 33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 23.9) and ovary adult (RPKM 2.7) See more
    Orthologs
    human all
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    Genomic context

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    See Ccdc33 in Genome Data Viewer
    Location:
    9 B; 9 31.63 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (57935956..58026111, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (58028673..58118823, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57804760-57804959 Neighboring gene sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A Neighboring gene STARR-positive B cell enhancer ABC_E8291 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57816329-57816438 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57819923-57820197 Neighboring gene STARR-seq mESC enhancer starr_24252 Neighboring gene STARR-positive B cell enhancer ABC_E2890 Neighboring gene STARR-seq mESC enhancer starr_24253 Neighboring gene Cyp11a1 promoter region Neighboring gene cytochrome P450, family 11, subfamily a, polypeptide 1 Neighboring gene ADP-ribosylation factor-like 6 interacting protein 1 pseudogene Neighboring gene predicted gene 16130 Neighboring gene stimulated by retinoic acid gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57960192-57960379 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:57981876-57982059 Neighboring gene immunoglobulin superfamily containing leucine-rich repeat Neighboring gene predicted gene, 39344

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ccdc33, a predominantly testis-expressed gene, encodes a putative peroxisomal protein. Kaczmarek K, et al. Cytogenet Genome Res, 2009. PMID 20068295
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Ccdc33 encodes a putative peroxisomal protein and is predominantly expressed in male germ cells.
      Title: Ccdc33, a predominantly testis-expressed gene, encodes a putative peroxisomal protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in spermatogenesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coiled-coil domain-containing protein 33
    Names
    speriolin-binding factor

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166282.2 → NP_001159754.1  coiled-coil domain-containing protein 33 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC158996
      Consensus CDS
      CCDS52811.1
      UniProtKB/Swiss-Prot
      Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
      UniProtKB/TrEMBL
      E9QQ55
      Related
      ENSMUSP00000096279.4, ENSMUST00000098682.10
      Conserved Domains (1) summary
      cd00030
      Location:282 → 364
      C2; C2 domain

    2. NM_001311085.2 → NP_001298014.1  coiled-coil domain-containing protein 33 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences compared to variant 1. These differences result in an isoform (2) that has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC158996
      Consensus CDS
      CCDS81006.1
      UniProtKB/TrEMBL
      D3YU68
      Related
      ENSMUSP00000112613.2, ENSMUST00000119665.2
      Conserved Domains (3) summary
      cd00030
      Location:37 → 119
      C2; C2 domain
      cd16269
      Location:495 → 506
      GBP_C; coiled coil [structural motif]
      cl20817
      Location:407 → 507
      GBP_C; Guanylate-binding protein, C-terminal domain

    3. NM_029212.4 → NP_083488.1  coiled-coil domain-containing protein 33 isoform 2

      See identical proteins and their annotated locations for NP_083488.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AC158996
      Consensus CDS
      CCDS40654.1
      UniProtKB/TrEMBL
      A0A0R4J0H2
      Related
      ENSMUSP00000040899.7, ENSMUST00000042205.13
      Conserved Domains (1) summary
      cd00030
      Location:37 → 119
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      57935956..58026111 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017313444.1 → XP_017168933.1  coiled-coil domain-containing protein 33 isoform X2

      UniProtKB/Swiss-Prot
      Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
      Conserved Domains (2) summary
      cd00030
      Location:282 → 364
      C2; C2 domain
      TIGR02169
      Location:648 → 831
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_017313445.1 → XP_017168934.1  coiled-coil domain-containing protein 33 isoform X3

      UniProtKB/Swiss-Prot
      Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
      Conserved Domains (2) summary
      cd00030
      Location:283 → 365
      C2; C2 domain
      TIGR02169
      Location:649 → 831
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    3. XM_017313447.1 → XP_017168936.1  coiled-coil domain-containing protein 33 isoform X5

      UniProtKB/TrEMBL
      A0A1L1SR74
      Conserved Domains (2) summary
      cd00030
      Location:283 → 365
      C2; C2 domain
      TIGR02169
      Location:649 → 832
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    4. XM_017313446.1 → XP_017168935.1  coiled-coil domain-containing protein 33 isoform X4

      UniProtKB/TrEMBL
      A0A1L1SR74
      Conserved Domains (2) summary
      cd00030
      Location:283 → 365
      C2; C2 domain
      TIGR02169
      Location:649 → 832
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    5. XM_006511252.1 → XP_006511315.1  coiled-coil domain-containing protein 33 isoform X1

      UniProtKB/Swiss-Prot
      Q14B78, Q3TLL8, Q3ULW6, Q76MG4, Q9D4Z2
      Conserved Domains (2) summary
      cd00030
      Location:283 → 365
      C2; C2 domain
      TIGR02169
      Location:649 → 832
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    6. XM_006511257.4 → XP_006511320.1  coiled-coil domain-containing protein 33 isoform X7

      Conserved Domains (1) summary
      TIGR02169
      Location:236 → 419
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    7. XM_006511254.4 → XP_006511317.1  coiled-coil domain-containing protein 33 isoform X6

      Conserved Domains (2) summary
      cd00030
      Location:37 → 119
      C2; C2 domain
      TIGR02169
      Location:403 → 586
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    8. XM_006511258.2 → XP_006511321.2  coiled-coil domain-containing protein 33 isoform X8

      Conserved Domains (1) summary
      TIGR02169
      Location:24 → 195
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    9. XM_006511259.2 → XP_006511322.2  coiled-coil domain-containing protein 33 isoform X9

      Conserved Domains (1) summary
      TIGR02169
      Location:24 → 195
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3ULW6.2 GenPept UniProtKB/Swiss-Prot:Q3ULW6

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