Nectin2 nectin cell adhesion molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nectin2provided by MGI
Official Full Name: nectin cell adhesion molecule 2provided by MGI
Primary source: MGI:MGI:97822
See related: Ensembl:ENSMUSG00000062300 AllianceGenome:MGI:97822
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MPH; Pvr; Pvs; Cd112; Pvrl2; nectin-2
Summary: Enables cell adhesion molecule binding activity and protein homodimerization activity. Involved in homophilic cell adhesion via plasma membrane adhesion molecules and spermatid development. Acts upstream of or within several processes, including establishment of mitochondrion localization; sperm mitochondrion organization; and spermatid development. Located in cell-cell contact zone; plasma membrane; and zonula adherens. Is expressed in brain; cochlea; enamel organ; male reproductive system; and metanephros. Human ortholog(s) of this gene implicated in Alzheimer's disease and multiple sclerosis. Orthologous to human NECTIN2 (nectin cell adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in duodenum adult (RPKM 62.2), colon adult (RPKM 44.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 9.94 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (19450569..19483498, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (19716644..19749573, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nectin-2alpha is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula.
Title: Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula.
CD112 Regulates Angiogenesis and T Cell Entry into the Spleen.
Title: CD112 Regulates Angiogenesis and T Cell Entry into the Spleen.
These results revealed the unique localization of nectin-2alpha and its regulatory role in the localization of Kv4.2 at the membrane specializations in the medial habenula.
Title: Localization of nectin-2α at the boundary between the adjacent somata of the clustered cholinergic neurons and its regulatory role in the subcellular localization of the voltage-gated A-type K(+) channel Kv4.2 in the medial habenula.
PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes.
Title: Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.
Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors.
Title: Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice.
We showed that cadherin and nectin in the junctions of A431 cells and human keratinocytes are located in separate clusters.
Title: The adherens junction: a mosaic of cadherin and nectin clusters bundled by actin filaments.
Nectin-2 is required to maintain structure and function of the intercalated disc and protects the heart from pressure-overload-induced cardiac dysfunction.
Title: Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.
expressed in early epithelial structures of the nephron generated from metanephric mesenchyme
Title: Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed.
Title: Disruption of ectoplasmic specializations between Sertoli cells and maturing spermatids by anti-nectin-2 and anti-nectin-3 antibodies.
nectins and afadin are involved in dynamic epithelial remodeling during mouse development
Title: Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI987993 (e-PCR)
- UniSTS:179534

AI325026 (e-PCR)
- UniSTS:159606

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion molecule binding	IBA Inferred from Biological aspect of Ancestor more info
enables cell adhesion molecule binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adhesion of symbiont to host	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular anatomical entity morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cilium organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in coreceptor-mediated virion attachment to host cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in coreceptor-mediated virion attachment to host cell	IEA Inferred from Electronic Annotation more info
involved_in coreceptor-mediated virion attachment to host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of mitochondrion localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within fertilization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fusion of virus membrane with host plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in fusion of virus membrane with host plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immunoglobulin mediated immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mast cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of mast cell activation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mast cell activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in regulation of viral entry into host cell	IEA Inferred from Electronic Annotation more info
involved_in regulation of viral entry into host cell	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sperm mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatid nucleus differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in susceptibility to T cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in susceptibility to T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in susceptibility to natural killer cell mediated cytotoxicity	IEA Inferred from Electronic Annotation more info
involved_in susceptibility to natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical junction complex	IBA Inferred from Biological aspect of Ancestor more info
located_in apical junction complex	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in zonula adherens	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nectin-2

Names: herpes virus entry mediator B; herpesvirus entry mediator B; hveB; mHveB; murine herpes virus entry protein B; murine herpesvirus entry protein B; poliovirus receptor homolog; poliovirus receptor-related 2; poliovirus receptor-related protein 2; poliovirus sensitivity

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001159724.1 → NP_001153196.1 nectin-2 isoform 2 precursor

See identical proteins and their annotated locations for NP_001153196.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 3' terminal exon compared to variant 1 that causes a frameshift. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.

Source sequence(s)

AC149282, AK075815, BQ033135

Consensus CDS

CCDS52063.1

UniProtKB/TrEMBL

Q3TZU9, Q91VT9

Related

ENSMUSP00000104089.4, ENSMUST00000108450.5

Conserved Domains (3) summary

cd05718
Location:48 → 150

Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins

smart00410
Location:40 → 149

IG_like; Immunoglobulin like

cl11960
Location:153 → 248

Ig; Immunoglobulin domain
NM_008990.3 → NP_033016.3 nectin-2 isoform 1 precursor

See identical proteins and their annotated locations for NP_033016.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC149282, BC046770

Consensus CDS

CCDS20913.1

UniProtKB/Swiss-Prot

P32507, Q62096

UniProtKB/TrEMBL

Q80XJ5

Related

ENSMUSP00000074898.8, ENSMUST00000075447.14

Conserved Domains (3) summary

cd05718
Location:48 → 150

Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins

smart00410
Location:40 → 149

IG_like; Immunoglobulin like

cl11960
Location:153 → 248

Ig; Immunoglobulin domain