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    Slc17a9 solute carrier family 17, member 9 [ Mus musculus (house mouse) ]

    Gene ID: 228993, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Slc17a9provided by MGI
    Official Full Name
    solute carrier family 17, member 9provided by MGI
    Primary source
    MGI:MGI:1919107
    See related
    Ensembl:ENSMUSG00000023393 AllianceGenome:MGI:1919107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vnut; 1700019H03Rik
    Summary
    Enables purine nucleotide uniporter activity. Involved in purine nucleotide import into lysosome. Acts upstream of with a positive effect on ATP export. Acts upstream of or within lysosomal protein catabolic process. Located in chromaffin granule membrane. Is active in lysosomal membrane. Is expressed in esophagus; male reproductive gland or organ; and nasal cavity epithelium. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human SLC17A9 (solute carrier family 17 member 9). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 55.9), genital fat pad adult (RPKM 48.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc17a9 in Genome Data Viewer
    Location:
    2 H4; 2 103.28 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (180363989..180384073)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180724576..180742280)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene death inducer-obliterator 1 Neighboring gene STARR-positive B cell enhancer mm9_chr2:180436639-180436940 Neighboring gene STARR-seq mESC enhancer starr_06736 Neighboring gene predicted gene, 22502 Neighboring gene STARR-positive B cell enhancer ABC_E9213 Neighboring gene GID complex subunit 8 Neighboring gene predicted gene, 30455 Neighboring gene STARR-seq mESC enhancer starr_06739 Neighboring gene STARR-positive B cell enhancer ABC_E1614 Neighboring gene basic helix-loop-helix family, member e23 Neighboring gene predicted gene 14340

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of vesicular nucleotide transporter VNUT (SLC17A9) in release of ATP from AR42J cells and mouse pancreatic acinar cells. Haanes KA, et al. Purinergic Signal, 2014 Sep. PMID 24488439, Free PMC Article
    2. The vesicular nucleotide transporter (VNUT) is involved in the extracellular ATP effect on neuronal differentiation. Menéndez-Méndez A, et al. Purinergic Signal, 2015 Jun. PMID 25847073, Free PMC Article
    3. Increased levels of extracellular ATP in glaucomatous retinas: Possible role of the vesicular nucleotide transporter during the development of the pathology. Pérez de Lara MJ, et al. Mol Vis, 2015. PMID 26392744, Free PMC Article
    4. Expression of Vesicular Nucleotide Transporter in the Mouse Retina. Moriyama S, et al. Biol Pharm Bull, 2016. PMID 27040629
    5. Impairment of vesicular ATP release affects glucose metabolism and increases insulin sensitivity. Sakamoto S, et al. Sci Rep, 2014 Oct 21. PMID 25331291, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
      Title: Clodronate, an inhibitor of the vesicular nucleotide transporter, ameliorates steatohepatitis and acute liver injury.
    2. VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation.
      Title: VNUT/SLC17A9, a vesicular nucleotide transporter, regulates osteoblast differentiation.
    3. Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression.
      Title: Live Imaging Reveals Cerebellar Neural Stem Cell Dynamics and the Role of VNUT in Lineage Progression.
    4. Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.
      Title: Transient Receptor Potential Vanilloid 4 Regulation of Adenosine Triphosphate Release by the Adenosine Triphosphate Transporter Vesicular Nucleotide Transporter, a Novel Therapeutic Target for Gastrointestinal Baroreception and Chronic Inflammation.
    5. expression of TRPV4 and VNUT in normal human gastrointestinal cell derived cell lines
      Title: Involvement of VNUT-exocytosis in transient receptor potential vanilloid 4-dependent ATP release from gastrointestinal epithelium.
    6. Data (including data from studies using knockout mice) suggest that Vnut/Slc17a9 localized in tertiary/secretory granules of neutrophils is responsible for vesicular ATP release and subsequent neutrophil migration/infiltration.
      Title: Vesicular nucleotide transporter mediates ATP release and migration in neutrophils.
    7. FLX-induced anti-depressive behavior was decreased in astrocyte-selective VNUT-knockout mice or when VNUT was deleted in mice, but it was increased when astrocyte-selective VNUT was overexpressed in mice
      Title: Anti-Depressant Fluoxetine Reveals its Therapeutic Effect Via Astrocytes.
    8. VNUT is necessary for exocytotic ATP release from spinal dorsal horn neurons which contributes to neuropathic pain.
      Title: Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain.
    9. This study provides a molecular mechanism for lysosomal ATP transport mediated by SLC17A9 and also suggests a regulatory mechanism of lysosomal P2X4 by SLC17A9
      Title: Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V-ATPase generated voltage gradient as the driving force.
    10. clock genes exist in the mouse bladder mucosa and regulate exact circadian gene expression in mice
      Title: Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC28538

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ADP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables ATP transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables guanine nucleotide transmembrane transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables purine nucleotide uniporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables purine nucleotide uniporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables purine nucleotide uniporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within ADP transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_positive_effect ATP export IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within ATP export ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_positive_effect ATP export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ATP transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ATP transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within guanine nucleotide transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within lysosomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide import into lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide import into lysosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromaffin granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromaffin granule membrane ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in lysosomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mucin granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mucin granule ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in secretory granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated purine nucleotide uniporter SLC17A9
    Names
    vesicular nucleotide transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183161.3 → NP_898984.3  voltage-gated purine nucleotide uniporter SLC17A9

      See identical proteins and their annotated locations for NP_898984.3

      Status: VALIDATED

      Source sequence(s)
      AK006122, AW554829, BE850231, BG087579, CF165170
      Consensus CDS
      CCDS38378.1
      UniProtKB/Swiss-Prot
      A2AJ51, Q8VCL5
      Related
      ENSMUSP00000091771.4, ENSMUST00000094218.4
      Conserved Domains (2) summary
      cd06174
      Location:40 → 432
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00893
      Location:43 → 424
      2A0114; D-galactonate transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      180363989..180384073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500591.3 → XP_006500654.1  voltage-gated purine nucleotide uniporter SLC17A9 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:112 → 367
      MFS; Major Facilitator Superfamily

    2. XM_006500589.3 → XP_006500652.1  voltage-gated purine nucleotide uniporter SLC17A9 isoform X1

      See identical proteins and their annotated locations for XP_006500652.1

      Conserved Domains (1) summary
      cd17380
      Location:42 → 377
      MFS_SLC17A9_like; Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters

    3. XM_006500590.5 → XP_006500653.1  voltage-gated purine nucleotide uniporter SLC17A9 isoform X1

      See identical proteins and their annotated locations for XP_006500653.1

      Conserved Domains (1) summary
      cd17380
      Location:42 → 377
      MFS_SLC17A9_like; Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters

    RNA

    1. XR_375393.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCL5.3 GenPept UniProtKB/Swiss-Prot:Q8VCL5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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