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    Qtrt2 queuine tRNA-ribosyltransferase accessory subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 106248, updated on 2-Nov-2024

    Summary

    Official Symbol
    Qtrt2provided by MGI
    Official Full Name
    queuine tRNA-ribosyltransferase accessory subunit 2provided by MGI
    Primary source
    MGI:MGI:1922194
    See related
    Ensembl:ENSMUSG00000022704 AllianceGenome:MGI:1922194
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Qrtr2; Qtrtd1; 3110012M05Rik; 4930470H18Rik
    Summary
    Predicted to enable protein heterodimerization activity; protein homodimerization activity; and tRNA binding activity. Involved in tRNA-guanine transglycosylation. Located in cytoplasmic side of mitochondrial outer membrane. Part of protein-containing complex. Orthologous to human QTRT2 (queuine tRNA-ribosyltransferase accessory subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 12.0), CNS E11.5 (RPKM 10.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Qtrt2 in Genome Data Viewer
    Location:
    16 B4; 16 28.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (43681879..43710063, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (43861407..43889797, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene dopamine receptor D3 Neighboring gene STARR-seq mESC enhancer starr_40887 Neighboring gene predicted gene, 26074 Neighboring gene STARR-seq mESC enhancer starr_40888 Neighboring gene STARR-positive B cell enhancer ABC_E1924 Neighboring gene predicted gene, 25989 Neighboring gene coiled-coil domain containing 191 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43951746-43952047 Neighboring gene zinc finger, DHHC domain containing 23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC102598

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tRNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables tRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables tRNA-guanosine(34) queuine transglycosylase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in tRNA-guanine transglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA-guanine transglycosylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in tRNA-guanine transglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasmic side of mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transferase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    queuine tRNA-ribosyltransferase accessory subunit 2
    Names
    queuine tRNA-ribosyltransferase domain containing 1
    queuine tRNA-ribosyltransferase domain-containing protein 1
    queuine tRNA-ribosyltransferase subunit QTRTD1
    NP_001343257.1
    NP_001343258.2
    NP_001392345.1
    NP_001392346.1
    NP_001392347.1
    NP_083404.3
    XP_006521733.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356328.2NP_001343257.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Conserved Domains (1) summary
      pfam01702
      Location:48322
      TGT; Queuine tRNA-ribosyltransferase
    2. NM_001356329.4NP_001343258.2  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Consensus CDS
      CCDS88930.1
      UniProtKB/Swiss-Prot
      A9C446, B8ZXI1, Q5XK35
      Related
      ENSMUSP00000158885.3, ENSMUST00000239112.3
    3. NM_001405416.1NP_001392345.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT025520
    4. NM_001405417.1NP_001392346.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025520
    5. NM_001405418.1NP_001392347.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT025520
    6. NM_029128.5NP_083404.3  queuine tRNA-ribosyltransferase accessory subunit 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Consensus CDS
      CCDS37344.1
      Related
      ENSMUSP00000023387.9, ENSMUST00000023387.15

    RNA

    1. NR_175937.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT025520
      Related
      ENSMUST00000156568.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      43681879..43710063 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521670.5XP_006521733.1  queuine tRNA-ribosyltransferase accessory subunit 2 isoform X2

      See identical proteins and their annotated locations for XP_006521733.1

      UniProtKB/TrEMBL
      A0A5F8MPN7, Z4YJE9
      Conserved Domains (1) summary
      pfam01702
      Location:14416
      TGT; Queuine tRNA-ribosyltransferase