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    Cd151 CD151 antigen [ Mus musculus (house mouse) ]

    Gene ID: 12476, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cd151provided by MGI
    Official Full Name
    CD151 antigenprovided by MGI
    Primary source
    MGI:MGI:1096360
    See related
    Ensembl:ENSMUSG00000025510 AllianceGenome:MGI:1096360
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SFA-1; PETA-3; Tspan24
    Summary
    Predicted to enable integrin binding activity. Acts upstream of or within T cell proliferation and cell migration. Predicted to be located in basement membrane and cell surface. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in epidermolysis bullosa simplex. Orthologous to human CD151 (CD151 molecule (Raph blood group)). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in adrenal adult (RPKM 306.7), ovary adult (RPKM 269.4) and 22 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cd151 in Genome Data Viewer
    Location:
    7 F5; 7 86.82 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (141047275..141051394)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141467362..141471481)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9305 Neighboring gene patatin-like phospholipase domain containing 2 Neighboring gene calcium release activated channel regulator 2B Neighboring gene predicted gene 10575 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L Neighboring gene STARR-positive B cell enhancer ABC_E11377 Neighboring gene tetraspanin 4 Neighboring gene chitinase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deletion of CD151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane. Baleato RM, et al. Am J Pathol, 2008 Oct. PMID 18787104, Free PMC Article
    2. Molecular cloning and expression of mouse homologue of SFA-1/PETA-3 (CD151), a member of the transmembrane 4 superfamily. Hasegawa H, et al. Biochim Biophys Acta, 1997 Aug 7. PMID 9294006
    3. Wound healing is defective in mice lacking tetraspanin CD151. Cowin AJ, et al. J Invest Dermatol, 2006 Mar. PMID 16410781, Free PMC Article
    4. Deletion of tetraspanin Cd151 results in decreased pathologic angiogenesis in vivo and in vitro. Takeda Y, et al. Blood, 2007 Feb 15. PMID 17023588, Free PMC Article
    5. The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: implications for wound healing. Geary SM, et al. Exp Cell Res, 2008 Jul 1. PMID 18534576

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of Cd151 blocks the activating effect of miR-199a-3p on cardiomyocyte proliferation, suggesting Cd151 is a functional target of miR-199a-3p in cardiomyocytes.
      Title: miR-199a-3p promotes cardiomyocyte proliferation by inhibiting Cd151 expression.
    2. our study suggests that CD151 is a key player in the Wnt oncogene-driven tumorigenesis and impacts breast cancer malignancy in a cell type-dependent manner.
      Title: Deletion of tetraspanin CD151 alters the Wnt oncogene-induced mammary tumorigenesis: A cell type-linked function and signaling.
    3. CD151 is a critical novel host factor of nuclear export signaling.
      Title: CD151, a novel host factor of nuclear export signaling in influenza virus infection.
    4. in complex with P2Y12 receptor contributes to thrombus growth and stability
      Title: A complementary role for tetraspanin superfamily member CD151 and ADP purinergic P2Y12 receptor in platelets.
    5. Tetraspanin CD151 Is a Negative Regulator of FcepsilonRI-Mediated Mast Cell Activation
      Title: Tetraspanin CD151 Is a Negative Regulator of FcεRI-Mediated Mast Cell Activation.
    6. Integrin-associated CD151 represses mammary branching morphogenesis by controlling progenitor cell activities, extracellular matrix integrity and transcription program.
      Title: CD151 represses mammary gland development by maintaining the niches of progenitor cells.
    7. Study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes.
      Title: Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.
    8. We identify CD151 as a critical factor in tetradecanoylphorbol acetate-dependent skin carcinogenesis.
      Title: Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151.
    9. Loss of CD151 is associated with drug sensitivity in skin squamous cell carcinoma.
      Title: Tetraspanin CD151 plays a key role in skin squamous cell carcinoma.
    10. study provides strong evidence that CD151 collaborates with LB integrins (particularly alpha6beta4 and ErbB2 (and EGFR) receptors to regulate multiple signaling pathways, thereby driving mammary tumor onset, survival, and metastasis
      Title: Integrin-associated CD151 drives ErbB2-evoked mammary tumor onset and metastasis.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables integrin binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables integrin binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within wound healing, spreading of cells ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basement membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CD151 antigen
    Names
    GP27
    membrane glycoprotein SFA-1
    platelet-endothelial tetraspan antigen 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111049.1 → NP_001104519.1  CD151 antigen

      See identical proteins and their annotated locations for NP_001104519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI155754, AW539552, BQ896459, DV063036, U89772
      Consensus CDS
      CCDS22017.1
      UniProtKB/Swiss-Prot
      O35566, O89118
      UniProtKB/TrEMBL
      Q921J7
      Related
      ENSMUSP00000136331.2, ENSMUST00000177840.9
      Conserved Domains (2) summary
      cd03155
      Location:112 → 220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15 → 248
      Tetraspannin; Tetraspanin family

    2. NM_001111050.1 → NP_001104520.1  CD151 antigen

      See identical proteins and their annotated locations for NP_001104520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI155754, AW539552, CJ066904, U89772
      Consensus CDS
      CCDS22017.1
      UniProtKB/Swiss-Prot
      O35566, O89118
      UniProtKB/TrEMBL
      Q921J7
      Related
      ENSMUSP00000061636.6, ENSMUST00000058746.7
      Conserved Domains (2) summary
      cd03155
      Location:112 → 220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15 → 248
      Tetraspannin; Tetraspanin family

    3. NM_009842.3 → NP_033972.2  CD151 antigen

      See identical proteins and their annotated locations for NP_033972.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AI155754, AW539552, BQ896459, D89290, U89772
      Consensus CDS
      CCDS22017.1
      UniProtKB/Swiss-Prot
      O35566, O89118
      UniProtKB/TrEMBL
      Q921J7
      Related
      ENSMUSP00000101622.3, ENSMUST00000106000.10
      Conserved Domains (2) summary
      cd03155
      Location:112 → 220
      CD151_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model ...
      pfam00335
      Location:15 → 248
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      141047275..141051394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35566.2 GenPept UniProtKB/Swiss-Prot:O35566

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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