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    Haus6 HAUS augmin-like complex, subunit 6 [ Mus musculus (house mouse) ]

    Gene ID: 230376, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Haus6provided by MGI
    Official Full Name
    HAUS augmin-like complex, subunit 6provided by MGI
    Primary source
    MGI:MGI:1923389
    See related
    Ensembl:ENSMUSG00000038047 AllianceGenome:MGI:1923389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Ertd27e; mKIAA1574; 9830144E06; 6230416J20Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to be located in centrosome. Predicted to be part of HAUS complex. Predicted to be active in mitotic spindle microtubule. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human HAUS6 (HAUS augmin like complex subunit 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 5.7), liver E14 (RPKM 3.9) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Haus6 in Genome Data Viewer
    Location:
    4 C4; 4 40.69 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (86497092..86530317, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (86578855..86612075, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene stabilizer of axonemal microtubules 1, opposite strand Neighboring gene STARR-positive B cell enhancer ABC_E4635 Neighboring gene STARR-positive B cell enhancer mm9_chr4:86225970-86226270 Neighboring gene Ras-related GTP binding A Neighboring gene small Cajal body-specific RNA 8 Neighboring gene STARR-positive B cell enhancer ABC_E2115 Neighboring gene STARR-seq mESC enhancer starr_10694 Neighboring gene perilipin 2 pseudogene Neighboring gene perilipin 2 Neighboring gene STARR-seq mESC enhancer starr_10695 Neighboring gene STARR-seq mESC enhancer starr_10697 Neighboring gene STARR-seq mESC enhancer starr_10698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:86358735-86358844 Neighboring gene predicted gene, 42312

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold. Schweizer N, et al. Nat Commun, 2021 Oct 15. PMID 34654813, Free PMC Article
    2. Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development. Watanabe S, et al. Cell Rep, 2016 Apr 5. PMID 27052165
    3. Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development. Viais R, et al. Elife, 2021 Aug 24. PMID 34427181, Free PMC Article
    4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
    5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.
      Title: Augmin deficiency in neural stem cells causes p53-dependent apoptosis and aborts brain development.
    2. Augmin is essential for embryonic cell division. Microtubule-organizing center clustering during the blastocyst stage requires augmin.
      Title: Intra-spindle Microtubule Assembly Regulates Clustering of Microtubule-Organizing Centers during Early Mouse Development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitotic spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 6
    Names
    likely ortholog of H. sapiens family with sequence similarity 29, member A (FAM29A)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173400.3 → NP_775576.2  HAUS augmin-like complex subunit 6

      See identical proteins and their annotated locations for NP_775576.2

      Status: VALIDATED

      Source sequence(s)
      AL824707, BB851382, BC068237, BX516644, BY471626
      Consensus CDS
      CCDS18307.1
      UniProtKB/TrEMBL
      Q69ZG0, Q6NV99
      Related
      ENSMUSP00000070504.8, ENSMUST00000070607.9
      Conserved Domains (1) summary
      pfam14661
      Location:15 → 238
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      86497092..86530317 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006537875.4 → XP_006537938.1  HAUS augmin-like complex subunit 6 isoform X1

      UniProtKB/TrEMBL
      Q69ZG0
      Conserved Domains (1) summary
      pfam14661
      Location:17 → 238
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

    2. XM_036163993.1 → XP_036019886.1  HAUS augmin-like complex subunit 6 isoform X3

      UniProtKB/TrEMBL
      Q6P252
      Conserved Domains (1) summary
      pfam14661
      Location:8 → 99
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

    3. XM_011250010.4 → XP_011248312.1  HAUS augmin-like complex subunit 6 isoform X2

      See identical proteins and their annotated locations for XP_011248312.1

      UniProtKB/TrEMBL
      Q6P252
      Conserved Domains (1) summary
      pfam14661
      Location:8 → 99
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus

    4. XM_011250011.2 → XP_011248313.1  HAUS augmin-like complex subunit 6 isoform X2

      See identical proteins and their annotated locations for XP_011248313.1

      UniProtKB/TrEMBL
      Q6P252
      Conserved Domains (1) summary
      pfam14661
      Location:8 → 99
      HAUS6_N; HAUS augmin-like complex subunit 6 N-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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