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    Zbtb10 zinc finger and BTB domain containing 10 [ Mus musculus (house mouse) ]

    Gene ID: 229055, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zbtb10provided by MGI
    Official Full Name
    zinc finger and BTB domain containing 10provided by MGI
    Primary source
    MGI:MGI:2139883
    See related
    Ensembl:ENSMUSG00000069114 AllianceGenome:MGI:2139883
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RINZF; 4832414A18
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and telomeric DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in chromosome, telomeric region and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZBTB10 (zinc finger and BTB domain containing 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in placenta adult (RPKM 9.7), CNS E11.5 (RPKM 3.6) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zbtb10 in Genome Data Viewer
    Location:
    3 A1; 3 2.25 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (9315627..9350393)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (9250567..9285333)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33018 Neighboring gene STARR-seq mESC enhancer starr_06898 Neighboring gene predicted gene, 52635 Neighboring gene STARR-seq mESC enhancer starr_06899 Neighboring gene STARR-positive B cell enhancer mm9_chr3:9249729-9250030 Neighboring gene STARR-seq mESC enhancer starr_06901 Neighboring gene predicted gene, 41997 Neighboring gene STARR-seq mESC enhancer starr_06902 Neighboring gene VISTA enhancer mm551 Neighboring gene RIKEN cDNA C030034L19 gene Neighboring gene STARR-seq mESC enhancer starr_06904 Neighboring gene zinc finger protein 704

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
    2. An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Pardo M, et al. Cell Stem Cell, 2010 Apr 2. PMID 20362542, Free PMC Article
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
    5. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomeric DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177660.3 → NP_808328.2  zinc finger and BTB domain-containing protein 10

      Status: VALIDATED

      Source sequence(s)
      AC126450, AK048280, AK048365, AK083443, BM899487, BY718125, CB525445, CJ114435, CK341409
      Consensus CDS
      CCDS50861.1
      UniProtKB/TrEMBL
      E9Q8X5
      Related
      ENSMUSP00000119386.2, ENSMUST00000155203.2
      Conserved Domains (6) summary
      smart00225
      Location:358 → 454
      BTB; Broad-Complex, Tramtrack and Bric a brac
      smart00597
      Location:242 → 309
      ZnF_TTF; zinc finger in transposases and transcription factors
      sd00017
      Location:716 → 736
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00651
      Location:347 → 453
      BTB; BTB/POZ domain
      pfam13465
      Location:729 → 753
      zf-H2C2_2; Zinc-finger double domain
      pfam13909
      Location:714 → 738
      zf-H2C2_5; C2H2-type zinc-finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      9315627..9350393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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    Chemical Information
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