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    Skic2 SKI2 subunit of superkiller complex [ Mus musculus (house mouse) ]

    Gene ID: 108077, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Skic2provided by MGI
    Official Full Name
    SKI2 subunit of superkiller complexprovided by MGI
    Primary source
    MGI:MGI:1099835
    See related
    Ensembl:ENSMUSG00000040356 AllianceGenome:MGI:1099835
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SKI; Ski2; Ddx13; Ski2w; Skiv2l; 4930534J06Rik
    Summary
    Predicted to enable 3'-5' RNA helicase activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay and rescue of stalled ribosome. Predicted to be located in nucleus. Predicted to be part of Ski complex. Is expressed in embryo. Human ortholog(s) of this gene implicated in trichohepatoenteric syndrome 2. Orthologous to human SKIC2 (SKI2 subunit of superkiller complex). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 57.5), testis adult (RPKM 55.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Skic2 in Genome Data Viewer
    Location:
    17 B1; 17 18.39 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35058202..35069180, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34839226..34850204, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene C4a promoter region Neighboring gene C4a androgen-responsive enhancer Neighboring gene serine/threonine kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E8920 Neighboring gene decapping exoribonuclease Neighboring gene microRNA 6971 Neighboring gene microRNA 6970 Neighboring gene STARR-positive B cell enhancer ABC_E5597 Neighboring gene negative elongation factor complex member E, Rdbp Neighboring gene microRNA 6972 Neighboring gene complement factor B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cytoplasmic RNA quality control failure engages mTORC1-mediated autoinflammatory disease. Yang K, et al. J Clin Invest, 2022 Jan 18. PMID 35040435, Free PMC Article
    2. Cloning of mDEAH9, a putative RNA helicase and mammalian homologue of Saccharomyces cerevisiae splicing factor Prp43. Gee S, et al. Proc Natl Acad Sci U S A, 1997 Oct 28. PMID 9342318, Free PMC Article
    3. Molecular analysis of the cDNA and genomic DNA encoding mouse RNA helicase A. Lee CG, et al. Genomics, 1998 Feb 1. PMID 9480750
    4. Organizations and gene duplications of the human and mouse MHC complement gene clusters. Yang Z, et al. Exp Clin Immunogenet, 2000. PMID 10686478
    5. The mouse as a model for the effects of MHC genes on human disease. Allcock RJ, et al. Immunol Today, 2000 Jul. PMID 10871872

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-5' RNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 3'-5' RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of Ski complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ski complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Ski complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    superkiller complex protein 2
    Names
    SKI2 subunit of superkiller complex protein
    superkiller viralicidic activity 2-like
    NP_067312.2
    XP_036016152.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021337.2 → NP_067312.2  superkiller complex protein 2

      See identical proteins and their annotated locations for NP_067312.2

      Status: VALIDATED

      Source sequence(s)
      AK087810, AK159854, CF546171
      Consensus CDS
      CCDS28661.1
      UniProtKB/Swiss-Prot
      Q3TW36, Q6NZR5
      UniProtKB/TrEMBL
      Q8CDP6
      Related
      ENSMUSP00000036265.10, ENSMUST00000046022.16
      Conserved Domains (5) summary
      smart00490
      Location:621 → 705
      HELICc; helicase superfamily c-terminal domain
      COG4581
      Location:288 → 1242
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]
      pfam00270
      Location:312 → 459
      DEAD; DEAD/DEAH box helicase
      pfam08148
      Location:1070 → 1236
      DSHCT; DSHCT (NUC185) domain
      pfam13234
      Location:762 → 1040
      rRNA_proc-arch; rRNA-processing arch domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35058202..35069180 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036160259.1 → XP_036016152.1  superkiller complex protein 2 isoform X1

      UniProtKB/TrEMBL
      Q8R3X0
      Conserved Domains (1) summary
      COG4581
      Location:1 → 893
      Dob10; Superfamily II RNA helicase [Replication, recombination and repair]

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_178062.2: Suppressed sequence

      Description
      NM_178062.2: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NZR5.1 GenPept UniProtKB/Swiss-Prot:Q6NZR5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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