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    Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 13079, updated on 2-Nov-2024

    Summary

    Official Symbol
    Cyp21a1provided by MGI
    Official Full Name
    cytochrome P450, family 21, subfamily a, polypeptide 1provided by MGI
    Primary source
    MGI:MGI:88591
    See related
    Ensembl:ENSMUSG00000024365 AllianceGenome:MGI:88591
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    21OH; 21-OH; 21OHA; 21OHB; Cyp21; Cyp21B; Oh21-1; Oh21-2; CYP21OH-A; Cyp21-ps1; Cyp21a2ps; Cyp21a2-ps
    Summary
    Predicted to enable 17-hydroxyprogesterone 21-hydroxylase activity; heme binding activity; and progesterone 21-hydroxylase activity. Predicted to be involved in progesterone metabolic process and steroid hormone biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; lung; metanephros; spleen; and testis. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward adrenal adult (RPKM 8124.5) See more
    Orthologs
    NEW
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    Genomic context

    See Cyp21a1 in Genome Data Viewer
    Location:
    17 B1; 17 18.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35020322..35023400, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34801348..34804426, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 19, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_42437 Neighboring gene STARR-seq mESC enhancer starr_42438 Neighboring gene superkiller viralicidic activity 2-like (S. cerevisiae), pseudogene 1 Neighboring gene tenascin XA (pseudogene) Neighboring gene Cyp21a1 5' regulatory region Neighboring gene STARR-seq mESC enhancer starr_42439 Neighboring gene complement C4A (Rodgers blood group) Neighboring gene C4a promoter region Neighboring gene C4a androgen-responsive enhancer Neighboring gene serine/threonine kinase 19 Neighboring gene STARR-positive B cell enhancer ABC_E8920

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC156449

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 17-hydroxyprogesterone 21-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 17-hydroxyprogesterone 21-hydroxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables heme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables progesterone 21-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables progesterone 21-hydroxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables steroid 21-monooxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables steroid 21-monooxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables steroid hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables steroid hydroxylase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in C21-steroid hormone biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glucocorticoid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mineralocorticoid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in progesterone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    steroid 21-hydroxylase
    Names
    21-OHase
    21-hydroxylase
    cytochrome P-450
    cytochrome P-450c21
    cytochrome P450 21
    cytochrome P450 XXI
    cytochrome P450 hydroxylase A
    cytochrome P450, 21, pseudogene
    cytochrome P450, 21, steroid 21 hydroxylase
    cytochrome P450, family 21, subfamily a, polypeptide 2, pseudogene
    cytochrome P450-C21
    NP_034125.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009995.2NP_034125.2  steroid 21-hydroxylase

      See identical proteins and their annotated locations for NP_034125.2

      Status: VALIDATED

      Source sequence(s)
      AI323066, AK146565, BC127167, BQ033552
      Consensus CDS
      CCDS28658.1
      UniProtKB/Swiss-Prot
      A0JP50, O88304, P03940, Q64510, Q9QX14
      UniProtKB/TrEMBL
      A0A0R4J048, Q3UJ92
      Related
      ENSMUSP00000025223.8, ENSMUST00000025223.9
      Conserved Domains (1) summary
      pfam00067
      Location:29471
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35020322..35023400 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_001363.1: Suppressed sequence

      Description
      NG_001363.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.