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    Ehmt2 euchromatic histone lysine N-methyltransferase 2 [ Mus musculus (house mouse) ]

    Gene ID: 110147, updated on 5-Nov-2024

    Summary

    Official Symbol
    Ehmt2provided by MGI
    Official Full Name
    euchromatic histone lysine N-methyltransferase 2provided by MGI
    Primary source
    MGI:MGI:2148922
    See related
    Ensembl:ENSMUSG00000013787 AllianceGenome:MGI:2148922
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G9a; Bat8; NG36; KMT1C; D17Ertd710e
    Summary
    Enables several functions, including C2H2 zinc finger domain binding activity; promoter-specific chromatin binding activity; and protein-lysine N-methyltransferase activity. Involved in DNA methylation-dependent heterochromatin formation and regulation of DNA replication. Acts upstream of or within several processes, including germ cell development; negative regulation of macromolecule biosynthetic process; and response to cocaine. Located in nucleus. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in idiopathic pulmonary fibrosis. Orthologous to human EHMT2 (euchromatic histone lysine methyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 86.7), testis adult (RPKM 83.8) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Ehmt2 in Genome Data Viewer
    Location:
    17 B1; 17 18.45 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35117427..35133049)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34898463..34914073)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene complement C2 Neighboring gene STARR-seq mESC enhancer starr_42440 Neighboring gene predicted gene, 40706 Neighboring gene zinc finger and BTB domain containing 12 Neighboring gene solute carrier family 44, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E958 Neighboring gene neuraminidase 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C2H2 zinc finger domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables C2H2 zinc finger domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K27 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K27 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K56 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K56 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H3K9 methyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables histone H3K9 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K9 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H3K9 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables histone H3K9me2 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables promoter-specific chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein-lysine N-methyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables transcription corepressor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in DNA methylation-dependent heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within behavioral response to cocaine IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to cocaine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within cellular response to starvation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fertilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-term memory IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in long-term memory ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within negative regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of gene expression via chromosomal CpG island methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within neuron fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within oocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-lysine dimethylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in peptidyl-lysine dimethylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within phenotypic switching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within protein methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein modification process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein modification process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to fungicide IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within synaptonemal complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    NOT located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    histone-lysine N-methyltransferase EHMT2
    Names
    H3-K9-HMTase 3
    HLA-B associated transcript 8
    histone H3-K9 methyltransferase 3
    histone-lysine N-methyltransferase, H3 lysine-9 specific 3
    protein G9a
    NP_001273502.1
    NP_001273504.1
    NP_001390796.1
    NP_001390798.1
    NP_001390799.1
    NP_665829.1
    NP_671493.1
    XP_030105308.1
    XP_036016153.1
    XP_036016154.1
    XP_036016155.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286573.2NP_001273502.1  histone-lysine N-methyltransferase EHMT2 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame internal coding exon, compared to variant 1. The resulting isoform (c) lacks an internal segment, compared to isoform a.
      Source sequence(s)
      CT025759
      Consensus CDS
      CCDS70798.1
      UniProtKB/TrEMBL
      A2CG76, Q3U4G9
      Related
      ENSMUSP00000094955.4, ENSMUST00000097342.10
      Conserved Domains (9) summary
      smart00468
      Location:9421041
      PreSET; N-terminal to some SET domains
      smart00317
      Location:10571179
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:9561197
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00204
      Location:705824
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:741834
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:804834
      ANK; ANK repeat [structural motif]
      cl02529
      Location:673724
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl09938
      Location:46226
      cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
      cl18951
      Location:573608
      Amidase; Amidase
    2. NM_001286575.2NP_001273504.1  histone-lysine N-methyltransferase EHMT2 isoform d

      See identical proteins and their annotated locations for NP_001273504.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has an alternate 5' terminal exon, which includes the 5' coding sequence, compared to variant 1. The resulting isoform (d) has a shorter and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      CT025759
      Consensus CDS
      CCDS70797.1
      UniProtKB/TrEMBL
      Q3U4G9
      Related
      ENSMUSP00000109667.3, ENSMUST00000114033.9
      Conserved Domains (7) summary
      smart00468
      Location:9191018
      PreSET; N-terminal to some SET domains
      smart00317
      Location:10341156
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:682801
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:718811
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:781811
      ANK; ANK repeat [structural motif]
      cl02529
      Location:650701
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl18951
      Location:550585
      Amidase; Amidase
    3. NM_001403867.1NP_001390796.1  histone-lysine N-methyltransferase EHMT2 isoform e

      Status: VALIDATED

      Source sequence(s)
      CT025759
    4. NM_001403869.1NP_001390798.1  histone-lysine N-methyltransferase EHMT2 isoform f

      Status: VALIDATED

      Source sequence(s)
      CT025759
    5. NM_001403870.1NP_001390799.1  histone-lysine N-methyltransferase EHMT2 isoform g

      Status: VALIDATED

      Source sequence(s)
      CT025759
    6. NM_145830.3NP_665829.1  histone-lysine N-methyltransferase EHMT2 isoform a

      See identical proteins and their annotated locations for NP_665829.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a, also known as G9a long).
      Source sequence(s)
      CT025759
      Consensus CDS
      CCDS28667.1
      UniProtKB/Swiss-Prot
      A2CG75, Q6PE08, Q8K4R6, Q8K4R7, Q9Z148, Q9Z149
      UniProtKB/TrEMBL
      Q3U4G9
      Related
      ENSMUSP00000013931.6, ENSMUST00000013931.12
      Conserved Domains (8) summary
      smart00468
      Location:9761075
      PreSET; N-terminal to some SET domains
      smart00317
      Location:10911213
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      COG2940
      Location:9901231
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd00204
      Location:739858
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:775868
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:838868
      ANK; ANK repeat [structural motif]
      cl02529
      Location:707758
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl18951
      Location:607642
      Amidase; Amidase
    7. NM_147151.3NP_671493.1  histone-lysine N-methyltransferase EHMT2 isoform b

      See identical proteins and their annotated locations for NP_671493.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' terminal exon which includes the 5' coding sequence, and lacks an in-frame internal coding exon, compared to variant 1. The resulting isoform (b, also known as G9a short) has a shorter and distinct N-terminus and lacks an internal segment, compared to isoform a.
      Source sequence(s)
      CT025759
      Consensus CDS
      CCDS28666.1
      UniProtKB/TrEMBL
      Q3U4G9
      Related
      ENSMUSP00000077208.7, ENSMUST00000078061.13
      Conserved Domains (7) summary
      smart00468
      Location:885984
      PreSET; N-terminal to some SET domains
      smart00317
      Location:10001122
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      cd00204
      Location:648767
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:684777
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:747777
      ANK; ANK repeat [structural motif]
      cl02529
      Location:616667
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      cl18951
      Location:516551
      Amidase; Amidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      35117427..35133049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249448.2XP_030105308.1  histone-lysine N-methyltransferase EHMT2 isoform X4

      UniProtKB/TrEMBL
      Q3U4G9
      Conserved Domains (5) summary
      PHA03247
      Location:23201
      PHA03247; large tegument protein UL36; Provisional
      COG0666
      Location:628793
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:757787
      ANK; ANK repeat [structural motif]
      pfam12796
      Location:761853
      Ank_2; Ankyrin repeats (3 copies)
      cd10533
      Location:9201158
      SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
    2. XM_036160261.1XP_036016154.1  histone-lysine N-methyltransferase EHMT2 isoform X5

      Conserved Domains (5) summary
      sd00045
      Location:585615
      ANK; ANK repeat [structural motif]
      cd10533
      Location:748986
      SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
      pfam12796
      Location:522615
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:210339
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
      cl18951
      Location:344379
      Amidase
    3. XM_036160260.1XP_036016153.1  histone-lysine N-methyltransferase EHMT2 isoform X5

      Conserved Domains (5) summary
      sd00045
      Location:585615
      ANK; ANK repeat [structural motif]
      cd10533
      Location:748986
      SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
      pfam12796
      Location:522615
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:210339
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
      cl18951
      Location:344379
      Amidase
    4. XM_036160262.1XP_036016155.1  histone-lysine N-methyltransferase EHMT2 isoform X6

      Conserved Domains (6) summary
      COG0666
      Location:419611
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00045
      Location:575605
      ANK; ANK repeat [structural motif]
      cd10533
      Location:738976
      SET_EHMT2; SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins
      pfam12796
      Location:512605
      Ank_2; Ankyrin repeats (3 copies)
      cd20905
      Location:210339
      EHMT_ZBD; Zinc-binding domain of euchromatic histone lysine methyltransferases EHMT1 and EHTM2
      cl18951
      Location:344379
      Amidase

    RNA

    1. XR_876459.2 RNA Sequence

    2. XR_001782028.2 RNA Sequence

    3. XR_003952076.2 RNA Sequence