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    Prrt1 proline-rich transmembrane protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 260297, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Prrt1provided by MGI
    Official Full Name
    proline-rich transmembrane protein 1provided by MGI
    Primary source
    MGI:MGI:1932118
    See related
    Ensembl:ENSMUSG00000015476 AllianceGenome:MGI:1932118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G5b; NG5; Bat4; Bat-4; DSPD1; ORF31; SynDIG4; D17H6S54E
    Summary
    Enables signaling receptor regulator activity. Involved in several processes, including long-term synaptic depression; protein localization to cell surface; and regulation of AMPA receptor activity. Acts upstream of or within several processes, including learning or memory; long-term synaptic potentiation; and synapse organization. Located in synaptic vesicle membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human PRRT1 (proline rich transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in thymus adult (RPKM 81.7), cerebellum adult (RPKM 35.3) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrt1 in Genome Data Viewer
    Location:
    17 B1; 17 18.21 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34848396..34852108)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34629365..34633134)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene EGF-like domain 8 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene STARR-positive B cell enhancer ABC_E770 Neighboring gene STARR-positive B cell enhancer ABC_E4212 Neighboring gene FK506 binding protein-like Neighboring gene activating transcription factor 6 beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking. Troyano-Rodriguez E, et al. Mol Cell Neurosci, 2019 Jul. PMID 31216424
    2. Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition. van der Spek SJF, et al. Cells, 2022 Nov 17. PMID 36429079, Free PMC Article
    3. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Kalashnikova E, et al. Neuron, 2010 Jan 14. PMID 20152115, Free PMC Article
    4. Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo. Chenaux G, et al. eNeuro, 2016 Sep-Oct. PMID 27800545, Free PMC Article
    5. SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function. Matt L, et al. Cell Rep, 2018 Feb 27. PMID 29490264, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRRT1 controls NMDA-induced trafficking of AMPA receptors in hippocampal neurons.
      Title: PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking.
    2. SynDIG4 maintains a pool of extrasynaptic AMPARs necessary for synapse development and function underlying higher-order cognitive plasticity.
      Title: SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within learning or memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in long-term synaptic depression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to cell surface IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of AMPA receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of AMPA receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proline-rich transmembrane protein 1
    Names
    dispanin subfamily D member 1
    synapse differentiation-induced protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368728.1 → NP_001355657.1  proline-rich transmembrane protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT009767
      Conserved Domains (1) summary
      pfam04505
      Location:217 → 284
      CD225; Interferon-induced transmembrane protein

    2. NM_001368729.1 → NP_001355658.1  proline-rich transmembrane protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT009767

    3. NM_001368730.1 → NP_001355659.1  proline-rich transmembrane protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT009767

    4. NM_030890.2 → NP_112152.1  proline-rich transmembrane protein 1 isoform 1

      See identical proteins and their annotated locations for NP_112152.1

      Status: VALIDATED

      Source sequence(s)
      CT009767
      Consensus CDS
      CCDS28653.1
      UniProtKB/Swiss-Prot
      O35449
      UniProtKB/TrEMBL
      A2CG20
      Related
      ENSMUSP00000015620.7, ENSMUST00000015620.7
      Conserved Domains (1) summary
      pfam04505
      Location:219 → 286
      CD225; Interferon-induced transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34848396..34852108
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246470.4 → XP_011244772.1  proline-rich transmembrane protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011244772.1

      Conserved Domains (1) summary
      pfam04505
      Location:256 → 323
      CD225; Interferon-induced transmembrane protein

    2. XM_036160615.1 → XP_036016508.1  proline-rich transmembrane protein 1 isoform X3

      Conserved Domains (1) summary
      pfam04505
      Location:217 → 284
      CD225; Interferon-induced transmembrane protein

    3. XM_030249815.1 → XP_030105675.1  proline-rich transmembrane protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35449.1 GenPept UniProtKB/Swiss-Prot:O35449

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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