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    Aifm3 apoptosis-inducing factor, mitochondrion-associated 3 [ Mus musculus (house mouse) ]

    Gene ID: 72168, updated on 3-Nov-2024

    Summary

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    Official Symbol
    Aifm3provided by MGI
    Official Full Name
    apoptosis-inducing factor, mitochondrion-associated 3provided by MGI
    Primary source
    MGI:MGI:1919418
    See related
    Ensembl:ENSMUSG00000022763 AllianceGenome:MGI:1919418
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aifl; 2810401C16Rik
    Summary
    Predicted to enable oxidoreductase activity, acting on NAD(P)H. Predicted to be involved in execution phase of apoptosis. Located in mitochondrion. Is expressed in cerebellum and heart. Orthologous to human AIFM3 (apoptosis inducing factor mitochondria associated 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 65.0), cortex adult (RPKM 36.8) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aifm3 in Genome Data Viewer
    Location:
    16 A3; 16 10.84 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (17307418..17325349)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (17489624..17507485)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene synaptosomal-associated protein 29 Neighboring gene STARR-positive B cell enhancer ABC_E4158 Neighboring gene STARR-seq mESC enhancer starr_40255 Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:17531169-17531278 Neighboring gene leucine-zipper-like transcriptional regulator, 1 Neighboring gene THAP domain containing 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Reactive oxygen species regulation by AIF- and complex I-depleted brain mitochondria. Chinta SJ, et al. Free Radic Biol Med, 2009 Apr 1. PMID 19280713, Free PMC Article
    2. Mouse and human CRKL is dosage sensitive for cardiac outflow tract formation. Racedo SE, et al. Am J Hum Genet, 2015 Feb 5. PMID 25658046, Free PMC Article
    3. Risk of meningomyelocele mediated by the common 22q11.2 deletion. Vong KI, et al. Science, 2024 May 3. PMID 38696583
    4. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article
    5. Mitochondrial protein interactome elucidated by chemical cross-linking mass spectrometry. Schweppe DK, et al. Proc Natl Acad Sci U S A, 2017 Feb 14. PMID 28130547, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 2 iron, 2 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in execution phase of apoptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in execution phase of apoptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in execution phase of apoptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    apoptosis-inducing factor 3
    Names
    apoptosis-inducing factor like
    apoptosis-inducing factor-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291070.1 → NP_001277999.1  apoptosis-inducing factor 3 isoform 1

      See identical proteins and their annotated locations for NP_001277999.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI835101, AK012958, AK158809
      Consensus CDS
      CCDS79430.1
      UniProtKB/Swiss-Prot
      Q0VBD6, Q3TY86, Q4VAA4, Q8BWV0
      Related
      ENSMUSP00000111349.2, ENSMUST00000115685.10
      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:198 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    2. NM_175178.4 → NP_780387.2  apoptosis-inducing factor 3 isoform 2

      See identical proteins and their annotated locations for NP_780387.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame alternate exon in the 3' coding region, compared to variant 1. It encodes a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AK158809, BY255255, CD742217
      Consensus CDS
      CCDS28003.1
      UniProtKB/Swiss-Prot
      Q3TY86
      Related
      ENSMUSP00000023448.7, ENSMUST00000023448.15
      Conserved Domains (5) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam00070
      Location:334 → 414
      Pyr_redox; Pyridine nucleotide-disulphide oxidoreductase
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal
      cl21454
      Location:196 → 285
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      17307418..17325349
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522595.4 → XP_006522658.1  apoptosis-inducing factor 3 isoform X7

      See identical proteins and their annotated locations for XP_006522658.1

      Conserved Domains (2) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    2. XM_036160135.1 → XP_036016028.1  apoptosis-inducing factor 3 isoform X7

      Conserved Domains (2) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    3. XM_006522590.4 → XP_006522653.1  apoptosis-inducing factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006522653.1

      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:198 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    4. XM_006522592.4 → XP_006522655.1  apoptosis-inducing factor 3 isoform X2

      See identical proteins and their annotated locations for XP_006522655.1

      UniProtKB/Swiss-Prot
      Q0VBD6, Q3TY86, Q4VAA4, Q8BWV0
      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:198 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    5. XM_036160134.1 → XP_036016027.1  apoptosis-inducing factor 3 isoform X6

      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:195 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 553
      Reductase_C; Reductase C-terminal

    6. XM_006522594.4 → XP_006522657.1  apoptosis-inducing factor 3 isoform X5

      Conserved Domains (2) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:198 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase

    7. XM_006522593.4 → XP_006522656.1  apoptosis-inducing factor 3 isoform X3

      Conserved Domains (3) summary
      cd03478
      Location:70 → 156
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:183 → 478
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:497 → 547
      Reductase_C; Reductase C-terminal

    8. XM_036160133.1 → XP_036016026.1  apoptosis-inducing factor 3 isoform X4

      Conserved Domains (3) summary
      cd03478
      Location:70 → 156
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:180 → 478
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:497 → 547
      Reductase_C; Reductase C-terminal

    9. XM_006522591.4 → XP_006522654.1  apoptosis-inducing factor 3 isoform X1

      See identical proteins and their annotated locations for XP_006522654.1

      Conserved Domains (3) summary
      cd03478
      Location:70 → 163
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:198 → 493
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:512 → 562
      Reductase_C; Reductase C-terminal

    10. XM_036160136.1 → XP_036016029.1  apoptosis-inducing factor 3 isoform X8

      Conserved Domains (3) summary
      cd03478
      Location:1 → 81
      Rieske_AIFL_N; AIFL (apoptosis-inducing factor like) family, N-terminal Rieske domain; members of this family show similarity to human AIFL, containing an N-terminal Rieske domain and a C-terminal pyridine nucleotide-disulfide oxidoreductase domain (Pyr_redox). The ...
      pfam07992
      Location:113 → 411
      Pyr_redox_2; Pyridine nucleotide-disulphide oxidoreductase
      pfam14759
      Location:430 → 480
      Reductase_C; Reductase C-terminal

    RNA

    1. XR_001781867.2 RNA Sequence

    2. XR_004939223.1 RNA Sequence

    3. XR_004939224.1 RNA Sequence

    4. XR_003951834.2 RNA Sequence

    5. XR_004939225.1 RNA Sequence

    6. XR_003951835.2 RNA Sequence

    7. XR_004939228.1 RNA Sequence

    8. XR_003951836.2 RNA Sequence

    9. XR_001781868.2 RNA Sequence

    10. XR_004939226.1 RNA Sequence

    11. XR_004939227.1 RNA Sequence

    12. XR_004939229.1 RNA Sequence

    13. XR_003951837.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TY86.1 GenPept UniProtKB/Swiss-Prot:Q3TY86

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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