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    Elovl2 ELOVL fatty acid elongase 2 [ Mus musculus (house mouse) ]

    Gene ID: 54326, updated on 2-Nov-2024

    Summary

    Official Symbol
    Elovl2provided by MGI
    Official Full Name
    ELOVL fatty acid elongase 2provided by MGI
    Primary source
    MGI:MGI:1858960
    See related
    Ensembl:ENSMUSG00000021364 AllianceGenome:MGI:1858960
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ssc2
    Summary
    Enables fatty acid elongase activity. Involved in fatty acid elongation, polyunsaturated fatty acid and very long-chain fatty acid biosynthetic process. Acts upstream of or within very long-chain fatty acid metabolic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including brain; liver; paravertebral ganglion; sensory organ; and urinary system. Orthologous to human ELOVL2 (ELOVL fatty acid elongase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in liver E18 (RPKM 67.6), liver adult (RPKM 66.2) and 12 other tissues See more
    Orthologs
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    Genomic context

    See Elovl2 in Genome Data Viewer
    Location:
    13 A3.3; 13 20.38 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41335858..41373879, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41182382..41220403, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene glial cells missing homolog 2 Neighboring gene synaptonemal complex protein 2-like Neighboring gene STARR-seq mESC enhancer starr_34300 Neighboring gene STARR-positive B cell enhancer ABC_E5387 Neighboring gene ribosomal protein S17, pseudogene 1 Neighboring gene predicted gene, 32063

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity, transferring groups other than amino-acyl groups IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fatty acid elongase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fatty acid elongase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables fatty acid elongase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in fatty acid elongation, monounsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, polyunsaturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, polyunsaturated fatty acid IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid elongation, polyunsaturated fatty acid IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid elongation, polyunsaturated fatty acid ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid elongation, saturated fatty acid IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in fatty acid elongation, saturated fatty acid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sphingolipid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in unsaturated fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in very long-chain fatty acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in very long-chain fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in very long-chain fatty acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in very long-chain fatty acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    very long chain fatty acid elongase 2
    Names
    3-keto acyl-CoA synthase Elovl2
    ELOVL FA elongase 2
    ELOVL family member 2
    elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
    elongation of very long chain fatty acids protein 2
    sequence similarity to Cig30 2
    very long chain 3-ketoacyl-CoA synthase 2
    very long chain 3-oxoacyl-CoA synthase 2
    NP_001298050.1
    NP_062296.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311121.1NP_001298050.1  very long chain fatty acid elongase 2 isoform 2

      See identical proteins and their annotated locations for NP_001298050.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon and includes an alternate 5' terminal exon compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC158538, AK014803
      Consensus CDS
      CCDS79180.1
      UniProtKB/TrEMBL
      A0A0R4J1P7, X2EXH0
      Related
      ENSMUSP00000114112.2, ENSMUST00000117096.2
      Conserved Domains (1) summary
      pfam01151
      Location:13247
      ELO; GNS1/SUR4 family
    2. NM_019423.2NP_062296.1  very long chain fatty acid elongase 2 isoform 1

      See identical proteins and their annotated locations for NP_062296.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BB277808, BB279541, BC098215, BY126714
      Consensus CDS
      CCDS36639.1
      UniProtKB/Swiss-Prot
      Q9D5Z2, Q9JLJ4
      UniProtKB/TrEMBL
      Q543J1, X2EXH0
      Related
      ENSMUSP00000021793.8, ENSMUST00000021793.15
      Conserved Domains (1) summary
      pfam01151
      Location:30264
      ELO; GNS1/SUR4 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      41335858..41373879 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)