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    Lrrc52 leucine rich repeat containing 52 [ Mus musculus (house mouse) ]

    Gene ID: 240899, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrrc52provided by MGI
    Official Full Name
    leucine rich repeat containing 52provided by MGI
    Primary source
    MGI:MGI:1924118
    See related
    Ensembl:ENSMUSG00000040485 AllianceGenome:MGI:1924118
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4930413P14Rik
    Summary
    Enables potassium channel activity. Acts upstream of or within establishment of localization in cell and potassium ion transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC52 (leucine rich repeat containing 52). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 28.1) See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc52 in Genome Data Viewer
    Location:
    1 H2.3; 1 74.83 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167273244..167294349, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167445675..167466780, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2583 Neighboring gene STARR-positive B cell enhancer ABC_E4378 Neighboring gene aldehyde dehydrogenase 9, subfamily A1 Neighboring gene STARR-positive B cell enhancer ABC_E4379 Neighboring gene microsomal glutathione S-transferase 3 Neighboring gene predicted gene, 34207 Neighboring gene STARR-seq mESC enhancer starr_02951 Neighboring gene STARR-seq mESC enhancer starr_02952 Neighboring gene retinoid X receptor gamma Neighboring gene LIM homeobox transcription factor 1 alpha

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression of the LRRC52 γ subunit (γ2) may provide Ca(2+)-independent activation of BK currents in mouse inner hair cells. Lang I, et al. FASEB J, 2019 Nov. PMID 31348683
    2. LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells. Lingle CJ, et al. Proc Natl Acad Sci U S A, 2019 Sep 10. PMID 31451634, Free PMC Article
    3. LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel. Yang C, et al. Proc Natl Acad Sci U S A, 2011 Nov 29. PMID 22084117, Free PMC Article
    4. Molecular Mechanism Underlying the Action of Zona-pellucida Glycoproteins on Mouse Sperm. Balbach M, et al. Front Cell Dev Biol, 2020. PMID 32984353, Free PMC Article
    5. SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility. Zeng XH, et al. Proc Natl Acad Sci U S A, 2015 Feb 24. PMID 25675513, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRRC52 is a gamma2 subunit of Big conductance and voltage- and Ca(2+)-activated K(+) channel complexes
      Title: Expression of the LRRC52 γ subunit (γ2) may provide Ca(2+)-independent activation of BK currents in mouse inner hair cells.
    2. LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells.
      Title: LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells.
    3. These results establish a critical role of LRRC52 in KSPER channels and demonstrate that loss of a non-pore-forming auxiliary subunit results in severe fertility impairment.
      Title: SLO3 auxiliary subunit LRRC52 controls gating of sperm KSPER currents and is critical for normal fertility.
    4. LRRC52 and LRRC26 define a new family of auxiliary subunits capable of critically modifying the gating behavior of Slo family channels.
      Title: LRRC52 (leucine-rich-repeat-containing protein 52), a testis-specific auxiliary subunit of the alkalization-activated Slo3 channel.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables potassium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of voltage-gated potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within reproductive process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 52
    Names
    BK channel auxiliary gamma subunit LRRC52
    BK channel auxilliary gamma subunit LRRC52

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013382.3 → NP_001013400.1  leucine-rich repeat-containing protein 52 precursor

      See identical proteins and their annotated locations for NP_001013400.1

      Status: VALIDATED

      Source sequence(s)
      AC113970
      Consensus CDS
      CCDS15458.1
      UniProtKB/Swiss-Prot
      Q5M8M9
      Related
      ENSMUSP00000047213.5, ENSMUST00000036643.6
      Conserved Domains (2) summary
      sd00033
      Location:56 → 78
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:79 → 136
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      167273244..167294349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5M8M9.1 GenPept UniProtKB/Swiss-Prot:Q5M8M9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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