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    Cfap68 cilia and flagella associated protein 68 [ Mus musculus (house mouse) ]

    Gene ID: 68721, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Cfap68provided by MGI
    Official Full Name
    cilia and flagella associated protein 68provided by MGI
    Primary source
    MGI:MGI:1915971
    See related
    Ensembl:ENSMUSG00000037971 AllianceGenome:MGI:1915971
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    c11orf1; 1110032A03Rik; 4930500N06Rik
    Summary
    Involved in flagellated sperm motility. Is active in axonemal A tubule inner sheath and sperm flagellum. Is expressed in several structures, including adipose tissue; alimentary system; hemolymphoid system gland; male reproductive gland or organ; and nervous system. Orthologous to human CFAP68 (cilia and flagella associated protein 68). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 65.0), genital fat pad adult (RPKM 10.5) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cfap68 in Genome Data Viewer
    Location:
    9 A5.3; 9 27.75 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (50672674..50679536, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (50761374..50768236, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2310030G06 gene Neighboring gene STARR-seq mESC enhancer starr_24121 Neighboring gene crystallin, alpha B Neighboring gene heat shock protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E3828 Neighboring gene STARR-positive B cell enhancer ABC_E9760 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene predicted gene, 57547

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The genomic determinants of alcohol preference in mice. Tabakoff B, et al. Mamm Genome, 2008 May. PMID 18563486, Free PMC Article
    2. Characterization of five novel human genes in the 11q13-q22 region. O'Brien KP, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873569
    3. Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Nguyen TTT, et al. Front Cell Dev Biol, 2024. PMID 38835510, Free PMC Article
    4. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. Mulligan MK, et al. Proc Natl Acad Sci U S A, 2006 Apr 18. PMID 16618939, Free PMC Article
    5. Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility. Zhou L, et al. Cell, 2023 Jun 22. PMID 37295417

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1)  1 citation
    • Targeted (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in flagellated sperm motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axonemal A tubule inner sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in axoneme ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in sperm flagellum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 68
    Names
    UPF0686 protein C11orf1 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311073.2 → NP_001298002.1  cilia- and flagella-associated protein 68 isoform 2

      See identical proteins and their annotated locations for NP_001298002.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate 5' terminal exon, which results in a different 5' UTR and use of an alternate start codon compared to variant 1. It encodes isoform 2, which is longer than and has a distinct N-terminus compared to isoform 1.
      Source sequence(s)
      AK015671, AK043513, AK161835, BQ175429, BU609920
      Consensus CDS
      CCDS80996.1
      UniProtKB/Swiss-Prot
      Q9D131
      Related
      ENSMUSP00000046890.5, ENSMUST00000042576.11
      Conserved Domains (1) summary
      pfam06608
      Location:25 → 164
      DUF1143; Protein of unknown function (DUF1143)

    2. NM_001361107.1 → NP_001348036.1  cilia- and flagella-associated protein 68 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC123614
      UniProtKB/TrEMBL
      H3BL73
      Related
      ENSMUSP00000135679.2, ENSMUST00000176238.2
      Conserved Domains (1) summary
      pfam06608
      Location:1 → 125
      DUF1143; Protein of unknown function (DUF1143)

    3. NM_001361108.1 → NP_001348037.1  cilia- and flagella-associated protein 68 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC123614
      Consensus CDS
      CCDS90565.1
      UniProtKB/TrEMBL
      H3BJ69
      Related
      ENSMUSP00000134870.2, ENSMUST00000177546.8
      Conserved Domains (1) summary
      pfam06608
      Location:14 → 71
      DUF1143; Protein of unknown function (DUF1143)

    4. NM_023483.4 → NP_075972.2  cilia- and flagella-associated protein 68 isoform 1

      See identical proteins and their annotated locations for NP_075972.2

      Status: VALIDATED

      Source sequence(s)
      AC123614, AK043513, AK161835, BQ175429, BU609920
      Consensus CDS
      CCDS23173.1
      UniProtKB/Swiss-Prot
      Q3TM17, Q3TYP3, Q4FK47, Q8K0A6, Q9D131, Q9D589, Q9JHT0
      Related
      ENSMUSP00000041803.3, ENSMUST00000042468.9
      Conserved Domains (1) summary
      pfam06608
      Location:1 → 148
      DUF1143; Protein of unknown function (DUF1143)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      50672674..50679536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030244552.1 → XP_030100412.1  cilia- and flagella-associated protein 68 isoform X2

    2. XM_006510578.5 → XP_006510641.1  cilia- and flagella-associated protein 68 isoform X1

      Conserved Domains (1) summary
      pfam06608
      Location:25 → 141
      DUF1143; Protein of unknown function (DUF1143)

    3. XM_036155233.1 → XP_036011126.1  cilia- and flagella-associated protein 68 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D131.1 GenPept UniProtKB/Swiss-Prot:Q9D131

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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