Agrp agouti related neuropeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Agrpprovided by MGI
Official Full Name: agouti related neuropeptideprovided by MGI
Primary source: MGI:MGI:892013
See related: Ensembl:ENSMUSG00000005705 AllianceGenome:MGI:892013
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Art; Agrt
Summary: This gene encodes a protein that regulates feeding behavior and plays a key role in the control of body weight. The encoded protein acts as an antagonist of melanocortin receptor signaling. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression: Ubiquitous expression in testis adult (RPKM 3.2), placenta adult (RPKM 1.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (106293327..106306477, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (105566695..105579845, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Kruppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice.
Title: Krüppel-like factor 4 in transcriptional control of the three unique isoforms of Agouti-related peptide in mice.
microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.
Title: microRNA-33 controls hunger signaling in hypothalamic AgRP neurons.
Opioidergic signaling contributes to food-mediated suppression of AgRP neurons.
Title: Opioidergic signaling contributes to food-mediated suppression of AgRP neurons.
AgRP neurons encode circadian feeding time.
Title: AgRP neurons encode circadian feeding time.
Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
Title: Melanocortin-3 receptor expression in AgRP neurons is required for normal activation of the neurons in response to energy deficiency.
AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.
Title: AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.
Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
Title: Nuclear receptor 5A2 regulation of Agrp underlies olanzapine-induced hyperphagia.
Bridging Energy Need and Feeding Behavior: The Impact of eIF2alpha Phosphorylation in AgRP Neurons.
Title: Bridging Energy Need and Feeding Behavior: The Impact of eIF2α Phosphorylation in AgRP Neurons.
AgRP neurons coordinate the mitigation of activity-based anorexia.
Title: AgRP neurons coordinate the mitigation of activity-based anorexia.
Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice.
Title: Agouti-related peptide neuronal silencing overcomes delayed puberty in neonatally underfed male mice.

Submit: New GeneRIF Correction See all GeneRIFs (103)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (9) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	ISS Inferred from Sequence or Structural Similarity more info
enables type 1 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 3 melanocortin receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables type 4 melanocortin receptor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in adult feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within adult feeding behavior	IDA Inferred from Direct Assay more info	PubMed
involved_in circadian rhythm	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
involved_in eating behavior	ISO Inferred from Sequence Orthology more info
involved_in hormone-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in long-day photoperiodism	IEA Inferred from Electronic Annotation more info
involved_in maternal process involved in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to insulin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi lumen	ISO Inferred from Sequence Orthology more info
located_in Golgi lumen	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: agouti-related protein

Names: orexigenic neuropeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271806.1 → NP_001258735.1 agouti-related protein precursor

See identical proteins and their annotated locations for NP_001258735.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC151573, AK138796, BC079902

Consensus CDS

CCDS22605.1

UniProtKB/Swiss-Prot

O35967, P56473

UniProtKB/TrEMBL

A0A0A6YX09, Q3UU47

Related

ENSMUSP00000141783.2, ENSMUST00000194654.2

Conserved Domains (1) summary

smart00792
Location:1 → 121

Agouti; Agouti protein
NM_007427.3 → NP_031453.1 agouti-related protein precursor

See identical proteins and their annotated locations for NP_031453.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AK138796, BC079902, CO044337

Consensus CDS

CCDS22605.1

UniProtKB/Swiss-Prot

O35967, P56473

UniProtKB/TrEMBL

A0A0A6YX09, Q3UU47

Related

ENSMUSP00000005849.6, ENSMUST00000005849.11

Conserved Domains (1) summary

smart00792
Location:1 → 121

Agouti; Agouti protein