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    Fhod1 formin homology 2 domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 234686, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Fhod1provided by MGI
    Official Full Name
    formin homology 2 domain containing 1provided by MGI
    Primary source
    MGI:MGI:2679008
    See related
    Ensembl:ENSMUSG00000014778 AllianceGenome:MGI:2679008
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FHOS; FHOS1
    Summary
    Predicted to enable actin filament binding activity and identical protein binding activity. Acts upstream of or within establishment of centrosome localization and nuclear migration. Located in intercalated disc. Is expressed in several structures, including gut; metanephros; nervous system; respiratory system; and sensory organ. Orthologous to human FHOD1 (formin homology 2 domain containing 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 37.9), spleen adult (RPKM 23.0) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fhod1 in Genome Data Viewer
    Location:
    8 D3; 8 53.04 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106055792..106074650, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105329160..105348062, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene F-box and leucine-rich repeat protein 9 Neighboring gene STARR-positive B cell enhancer ABC_E11746 Neighboring gene transmembrane protein 208 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:107871965-107872074 Neighboring gene predicted gene, 46049 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 5 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 4 Neighboring gene potassium channel tetramerisation domain containing 19

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division. Pan MH, et al. J Cell Physiol, 2018 Mar. PMID 28708292
    2. FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration. Iskratsch T, et al. Dev Cell, 2013 Dec 9. PMID 24331927, Free PMC Article
    3. Loss of mDia1 and Fhod1 impacts platelet formation but not platelet function. Zuidscherwoude M, et al. Platelets, 2021 Nov 17. PMID 32981398, Free PMC Article
    4. G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets. Thomas SG, et al. J Thromb Haemost, 2011 Aug. PMID 21605332
    5. Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice. Sanematsu F, et al. Cytoskeleton (Hoboken), 2019 Feb. PMID 31008549

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fhod1 appears to be dispensable for normal development and function of the mouse heart, even if a marginal amount of Fhod1 is expressed in the heart.
      Title: Fhod1, an actin-organizing formin family protein, is dispensable for cardiac development and function in mice.
    2. FHOD1 is regulated by ROCK for cytoplasm actin assembly and spindle migration during mouse oocyte meiosis.
      Title: FHOD1 regulates cytoplasmic actin-based spindle migration for mouse oocyte asymmetric cell division.
    3. Report FODH1 expression in cardiomyocytes.
      Title: The formin FHOD1 in cardiomyocytes.
    4. We report here that a major formin in mouse fibroblasts, FHOD1, is recruited to integrin clusters, resulting in actin assembly.
      Title: FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration.
    5. Letter: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
      Title: G-protein coupled and ITAM receptor regulation of the formin FHOD1 through Rho kinase in platelets.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cortical actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within establishment of centrosome localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in bleb IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intercalated disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stress fiber IEA
    Inferred from Electronic Annotation
    more info
    		  
    colocalizes_with stress fiber ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    FH1/FH2 domain-containing protein 1
    Names
    formin homolog overexpressed in spleen 1
    formin homology 2 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177699.4 → NP_808367.2  FH1/FH2 domain-containing protein 1

      See identical proteins and their annotated locations for NP_808367.2

      Status: VALIDATED

      Source sequence(s)
      AB041045, AW540395, BB858085
      Consensus CDS
      CCDS22600.1
      UniProtKB/Swiss-Prot
      Q6P9Q4, Q8BMK2
      Related
      ENSMUSP00000014922.5, ENSMUST00000014922.5
      Conserved Domains (1) summary
      pfam02181
      Location:648 → 1020
      FH2; Formin Homology 2 Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106055792..106074650 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153970.1 → XP_036009863.1  FH1/FH2 domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      pfam02181
      Location:674 → 1046
      FH2; Formin Homology 2 Domain
      pfam18382
      Location:17 → 115
      Formin_GBD_N; Formin N-terminal GTPase-binding domain

    2. XM_030243503.1 → XP_030099363.1  FH1/FH2 domain-containing protein 1 isoform X3

      Conserved Domains (1) summary
      pfam02181
      Location:343 → 715
      FH2; Formin Homology 2 Domain

    3. XM_036153971.1 → XP_036009864.1  FH1/FH2 domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02181
      Location:369 → 741
      FH2; Formin Homology 2 Domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P9Q4.3 GenPept UniProtKB/Swiss-Prot:Q6P9Q4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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