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    Ebf3 early B cell factor 3 [ Mus musculus (house mouse) ]

    Gene ID: 13593, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ebf3provided by MGI
    Official Full Name
    early B cell factor 3provided by MGI
    Primary source
    MGI:MGI:894289
    See related
    Ensembl:ENSMUSG00000010476 AllianceGenome:MGI:894289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    O/E-2; mKIAA4201; 3110018A08Rik
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within positive regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; limb; musculoskeletal system; and sensory organ. Human ortholog(s) of this gene implicated in hypotonia, ataxia, and delayed development syndrome. Orthologous to human EBF3 (EBF transcription factor 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in CNS E14 (RPKM 24.6), limb E14.5 (RPKM 23.6) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ebf3 in Genome Data Viewer
    Location:
    7 F3- F4; 7 82.26 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (136795400..136924528, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (137193671..137322805, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene O-6-methylguanine-DNA methyltransferase Neighboring gene predicted gene, 39108 Neighboring gene STARR-seq mESC enhancer starr_20380 Neighboring gene STARR-seq mESC enhancer starr_20381 Neighboring gene predicted gene, 30061 Neighboring gene STARR-seq mESC enhancer starr_20382 Neighboring gene predicted gene 10578 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:144481070-144481271 Neighboring gene STARR-seq mESC enhancer starr_20383 Neighboring gene RIKEN cDNA 9430038I01 gene Neighboring gene STARR-positive B cell enhancer ABC_E2852 Neighboring gene nucleolin pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Ebf3(+) niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells. Nakatani T, et al. Nat Commun, 2023 Oct 25. PMID 37880234, Free PMC Article
    2. Ebf3-miR218 regulation is involved in the development of dopaminergic neurons. Baek S, et al. Brain Res, 2014 Oct 31. PMID 25192643
    3. A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells. Iwai R, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29113800
    4. The characterization of the Olf-1/EBF-like HLH transcription factor family: implications in olfactory gene regulation and neuronal development. Wang SS, et al. J Neurosci, 1997 Jun 1. PMID 9151732, Free PMC Article
    5. Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study. Hu W, et al. Cell Signal, 2024 Jun. PMID 38479556

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
      Title: Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study.
    2. Ebf3[+] niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.
      Title: Ebf3(+) niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.
    3. The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.
      Title: The caudo-ventral pallium is a novel pallial domain expressing Gdf10 and generating Ebf3-positive neurons of the medial amygdala.
    4. HSC cellular niches express Ebf3 that is required to create HSC niches, to inhibit their osteoblast differentiation, and to maintain spaces for HSCs.
      Title: Stem cell niche-specific Ebf3 maintains the bone marrow cavity.
    5. data show that Prdm13 is not required for amacrine fate as a class, but is essential for the formation of Ebf3+ amacrine cell subtypes. Rather than driving subtype identity, Prdm13 may act by restricting competing fate programs to maintain identity and survival.
      Title: Prdm13 is required for Ebf3+ amacrine cell formation in the retina.
    6. Our findings highlight the critical role of Ebf3 in multipolar-to-bipolar transition via positive feedback regulation of NeuroD1 in the developing neocortex.
      Title: A Prdm8 target gene Ebf3 regulates multipolar-to-bipolar transition in migrating neocortical cells.
    7. Ebf3 is a new regulator of terminal muscle differentiation in the diaphragm, and Ebf factors cooperate with MyoD in the induction of muscle-specific genes
      Title: Ebf factors and MyoD cooperate to regulate muscle relaxation via Atp2a1.
    8. The regulation of Ebf3 expression by miR218 controls the terminal differentiation of dopaminergic neurons.
      Title: Ebf3-miR218 regulation is involved in the development of dopaminergic neurons.
    9. Ebf2 and Ebf3, singly or together, control the migration of Cajal-Retzius cells arising in the cortical hem. These findings provide evidence that Ebfs directly regulate Cajal-Retzius cell development
      Title: Early B-cell factors 2 and 3 (EBF2/3) regulate early migration of Cajal-Retzius cells from the cortical hem.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4201

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transcription factor COE3
    Names
    EBF-3
    OE-2
    Olf-1/EBF-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113414.2 → NP_001106885.1  transcription factor COE3 isoform 2

      See identical proteins and their annotated locations for NP_001106885.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternative, in-frame donor splice site at one of the internal coding exons, compared to transcript variant 1. This results in a shorter isoform (2) that is missing a 9 aa segment, compared to isoform 1.
      Source sequence(s)
      AC135639
      Consensus CDS
      CCDS52423.1
      UniProtKB/TrEMBL
      Q6NXL3, Q8CBL7
      Related
      ENSMUSP00000132563.3, ENSMUST00000169486.9
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    2. NM_001113415.2 → NP_001106886.1  transcription factor COE3 isoform 1

      See identical proteins and their annotated locations for NP_001106886.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1)
      Source sequence(s)
      AC135639
      Consensus CDS
      CCDS52422.1
      UniProtKB/Swiss-Prot
      O08791, O08793
      UniProtKB/TrEMBL
      Q8CBL7
      Related
      ENSMUSP00000147829.2, ENSMUST00000210774.2
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    3. NM_010096.4 → NP_034226.1  transcription factor COE3 isoform 3

      See identical proteins and their annotated locations for NP_034226.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate, in-frame donor acceptor site at the penultimate coding exon, and an alternative, in-frame donor splice site at one of the internal coding exons, compared to transcript variant 1. This results in a shorter isoform (3) that is missing 36 aa and 9 aa segments, compared to isoform 1.
      Source sequence(s)
      AC135639
      Consensus CDS
      CCDS21946.1
      UniProtKB/TrEMBL
      Q5DTH8
      Related
      ENSMUSP00000033378.6, ENSMUST00000033378.13
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      136795400..136924528 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152643.1 → XP_036008536.1  transcription factor COE3 isoform X1

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    2. XM_036152647.1 → XP_036008540.1  transcription factor COE3 isoform X3

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    3. XM_036152646.1 → XP_036008539.1  transcription factor COE3 isoform X3

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    4. XM_036152645.1 → XP_036008538.1  transcription factor COE3 isoform X1

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    5. XM_036152644.1 → XP_036008537.1  transcription factor COE3 isoform X1

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    6. XM_006507334.3 → XP_006507397.1  transcription factor COE3 isoform X10

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    7. XM_006507336.3 → XP_006507399.1  transcription factor COE3 isoform X14

      See identical proteins and their annotated locations for XP_006507399.1

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    8. XM_006507331.3 → XP_006507394.1  transcription factor COE3 isoform X2

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    9. XM_030242085.2 → XP_030097945.1  transcription factor COE3 isoform X1

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    10. XM_030242086.2 → XP_030097946.1  transcription factor COE3 isoform X4

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    11. XM_030242094.2 → XP_030097954.1  transcription factor COE3 isoform X17

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain

    12. XM_030242092.2 → XP_030097952.1  transcription factor COE3 isoform X13

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    13. XM_006507333.3 → XP_006507396.1  transcription factor COE3 isoform X6

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    14. XM_030242095.2 → XP_030097955.1  transcription factor COE3 isoform X18

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    15. XM_011241672.3 → XP_011239974.1  transcription factor COE3 isoform X15

      See identical proteins and their annotated locations for XP_011239974.1

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    16. XM_006507332.3 → XP_006507395.1  transcription factor COE3 isoform X3

      UniProtKB/TrEMBL
      Q8CBL7
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    17. XM_030242087.2 → XP_030097947.1  transcription factor COE3 isoform X5

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    18. XM_030242088.2 → XP_030097948.1  transcription factor COE3 isoform X7

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    19. XM_030242093.2 → XP_030097953.1  transcription factor COE3 isoform X16

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    20. XM_036152651.1 → XP_036008544.1  transcription factor COE3 isoform X21

      Conserved Domains (3) summary
      cd01175
      Location:47 → 131
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16423
      Location:132 → 175
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
      cl17007
      Location:1 → 40
      COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

    21. XM_036152650.1 → XP_036008543.1  transcription factor COE3 isoform X20

      Conserved Domains (3) summary
      cd01175
      Location:56 → 140
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16423
      Location:141 → 184
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
      cl17007
      Location:1 → 40
      COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

    22. XM_036152652.1 → XP_036008545.1  transcription factor COE3 isoform X22

      Conserved Domains (3) summary
      cd01175
      Location:47 → 131
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16423
      Location:132 → 175
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
      cl17007
      Location:1 → 40
      COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

    23. XM_030242090.2 → XP_030097950.1  transcription factor COE3 isoform X9

      UniProtKB/TrEMBL
      Q6NXL3, Q8CBL7
      Related
      ENSMUSP00000101724.4, ENSMUST00000106118.10
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    24. XM_006507335.3 → XP_006507398.1  transcription factor COE3 isoform X11

      See identical proteins and their annotated locations for XP_006507398.1

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    25. XM_036152653.1 → XP_036008546.1  transcription factor COE3 isoform X23

      UniProtKB/TrEMBL
      Q3UUB6
      Related
      ENSMUSP00000147512.2, ENSMUST00000209578.2
      Conserved Domains (3) summary
      cd01175
      Location:47 → 131
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16423
      Location:132 → 175
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
      cl17007
      Location:1 → 40
      COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain

    26. XM_030242091.2 → XP_030097951.1  transcription factor COE3 isoform X12

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    27. XM_030242089.2 → XP_030097949.1  transcription factor COE3 isoform X8

      UniProtKB/TrEMBL
      Q5DTH8
      Conserved Domains (3) summary
      cd01175
      Location:254 → 338
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:339 → 382
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain

    28. XM_006507337.5 → XP_006507400.1  transcription factor COE3 isoform X19

      Conserved Domains (3) summary
      cd01175
      Location:263 → 347
      IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
      pfam16422
      Location:21 → 247
      COE1_DBD; Transcription factor COE1 DNA-binding domain
      pfam16423
      Location:348 → 391
      COE1_HLH; Transcription factor COE1 helix-loop-helix domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08791.1 GenPept UniProtKB/Swiss-Prot:O08791

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