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    Myo18b myosin XVIIIb [ Mus musculus (house mouse) ]

    Gene ID: 74376, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Myo18bprovided by MGI
    Official Full Name
    myosin XVIIIbprovided by MGI
    Primary source
    MGI:MGI:1921626
    See related
    Ensembl:ENSMUSG00000072720 AllianceGenome:MGI:1921626
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm448; 4932408L24Rik; 4933411E19Rik
    Summary
    Predicted to enable actin filament binding activity. Acts upstream of or within cardiac muscle cell development; in utero embryonic development; and vasculogenesis. Located in Z disc. Part of filamentous actin. Is expressed in several structures, including diaphragm; heart; and musculature. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 4. Orthologous to human MYO18B (myosin XVIIIB). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in heart adult (RPKM 19.1), testis adult (RPKM 6.8) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Myo18b in Genome Data Viewer
    Location:
    5 F; 5 54.8 cM
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (112836742..113044311, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (112688876..112896461, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700034G24 gene Neighboring gene VISTA enhancer mm1731 Neighboring gene STARR-seq mESC enhancer starr_14014 Neighboring gene predicted gene, 30529 Neighboring gene RIKEN cDNA 1700095B10 gene Neighboring gene STARR-seq mESC enhancer starr_14016 Neighboring gene G protein-coupled receptor kinase 3 Neighboring gene predicted gene, 22740

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. miR‑760 regulates skeletal muscle proliferation in rheumatoid arthritis by targeting Myo18b. Tang X, et al. Mol Med Rep, 2019 Dec. PMID 31661144, Free PMC Article
    2. HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth. Ajima R, et al. Biochem Biophys Res Commun, 2007 May 18. PMID 17386922
    3. Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation. Salamon M, et al. J Mol Biol, 2003 Feb 7. PMID 12547197
    4. Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations. Ajima R, et al. Genes Cells, 2008 Oct. PMID 18761673
    5. Majority of cerebrospinal fluid-contacting neurons in the spinal cord of C57Bl/6N mice is present in ectopic position unlike in other studied experimental mice strains and mammalian species. Tonelli Gombalová Z, et al. J Comp Neurol, 2020 Oct 15. PMID 32212159

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Overexpression of miR760 decreased proliferation, cell cycle progression, migration and differentiation in C2C12 myoblasts, and decreased the expression of Myo18b.
      Title: miR‑760 regulates skeletal muscle proliferation in rheumatoid arthritis by targeting Myo18b.
    2. Myo18B is a unique unconventional myosin that is predominantly expressed in myocytes and whose expression is essential for the development and/or maintenance of myofibrillar structure.
      Title: Deficiency of Myo18B in mice results in embryonic lethality with cardiac myofibrillar aberrations.
    3. Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression.
      Title: HOMER2 binds MYO18B and enhances its activity to suppress anchorage independent growth.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cardiac muscle cell development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vasculogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of filamentous actin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in myosin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of unconventional myosin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of unconventional myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    unconventional myosin-XVIIIb

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028901.2 → NP_083177.2  unconventional myosin-XVIIIb

      See identical proteins and their annotated locations for NP_083177.2

      Status: VALIDATED

      Source sequence(s)
      AC122466, AC149590
      Consensus CDS
      CCDS51618.1
      UniProtKB/TrEMBL
      E9PV66
      Related
      ENSMUSP00000083810.5, ENSMUST00000086617.11
      Conserved Domains (4) summary
      PHA03247
      Location:55 → 472
      PHA03247; large tegument protein UL36; Provisional
      COG5022
      Location:606 → 2126
      COG5022; Myosin heavy chain [General function prediction only]
      cd01386
      Location:625 → 1361
      MYSc_Myo18; class XVIII myosin, motor domain
      pfam15308
      Location:2123 → 2365
      CEP170_C; CEP170 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      112836742..113044311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535262.4 → XP_006535325.1  unconventional myosin-XVIIIb isoform X1

      See identical proteins and their annotated locations for XP_006535325.1

      UniProtKB/TrEMBL
      E9PV66
      Conserved Domains (4) summary
      PHA03247
      Location:55 → 472
      PHA03247; large tegument protein UL36; Provisional
      COG5022
      Location:606 → 2126
      COG5022; Myosin heavy chain [General function prediction only]
      cd01386
      Location:625 → 1361
      MYSc_Myo18; class XVIII myosin, motor domain
      pfam15308
      Location:2123 → 2365
      CEP170_C; CEP170 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version

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