Prss51 serine protease 51 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prss51provided by MGI
Official Full Name: serine protease 51provided by MGI
Primary source: MGI:MGI:1921465
See related: Ensembl:ENSMUSG00000052099 AllianceGenome:MGI:1921465
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1700007N14Rik
Summary: Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be active in extracellular space and secretory granule. Orthologous to human PRSS51 (serine protease 51). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward testis adult (RPKM 14.7) See more
Orthologs: human all
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Genomic context

Location:: 14 D1; 14 33.35 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (64322974..64335123)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (64085525..64097674)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prss55 but not Prss51 is required for male fertility in micedagger.
Title: Prss55 but not Prss51 is required for male fertility in mice†.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein maturation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: serine protease-like protein 51

Names: protease, serine 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001193631.1 → NP_001180560.1 serine protease-like protein 51 isoform 1

See identical proteins and their annotated locations for NP_001180560.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC166997

Consensus CDS

CCDS56964.1

UniProtKB/TrEMBL

E9PXD1

Related

ENSMUSP00000132814.2, ENSMUST00000165710.2

Conserved Domains (1) summary

cl21584
Location:5 → 189

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
NM_001347631.1 → NP_001334560.1 serine protease-like protein 51 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, and uses an alternate splice site in the 5' coding region relative to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AK005740, AV172114

Consensus CDS

CCDS84145.1

UniProtKB/TrEMBL

Q9DAL4

Related

ENSMUSP00000066111.6, ENSMUST00000063785.12

Conserved Domains (1) summary

cl21584
Location:40 → 171

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

64322974..64335123

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244872.3 → XP_011243174.1 serine protease-like protein 51 isoform X1

See identical proteins and their annotated locations for XP_011243174.1

UniProtKB/TrEMBL

A0A286YDY8

Conserved Domains (1) summary

smart00020
Location:73 → 296

Tryp_SPc; Trypsin-like serine protease
XM_006518308.4 → XP_006518371.1 serine protease-like protein 51 isoform X2

See identical proteins and their annotated locations for XP_006518371.1

UniProtKB/TrEMBL

A0A286YDY8

Conserved Domains (1) summary

smart00020
Location:3 → 210

Tryp_SPc; Trypsin-like serine protease
XM_006518312.1 → XP_006518375.1 serine protease-like protein 51 isoform X3

See identical proteins and their annotated locations for XP_006518375.1

UniProtKB/TrEMBL

E9PXD1

Conserved Domains (1) summary

cl21584
Location:5 → 189

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_006518306.4 → XP_006518369.1 serine protease-like protein 51 isoform X1

See identical proteins and their annotated locations for XP_006518369.1

UniProtKB/TrEMBL

A0A286YDY8

Related

ENSMUSP00000153617.2, ENSMUST00000224112.2

Conserved Domains (1) summary

smart00020
Location:73 → 296

Tryp_SPc; Trypsin-like serine protease
XM_030247572.1 → XP_030103432.1 serine protease-like protein 51 isoform X2

UniProtKB/TrEMBL

A0A286YDY8

Conserved Domains (1) summary

smart00020
Location:3 → 210

Tryp_SPc; Trypsin-like serine protease
XM_030247573.1 → XP_030103433.1 serine protease-like protein 51 isoform X4

UniProtKB/TrEMBL

Q9DAL4

Conserved Domains (1) summary

cl21584
Location:40 → 171

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
XM_030247574.1 → XP_030103434.1 serine protease-like protein 51 isoform X4

UniProtKB/TrEMBL

Q9DAL4

Conserved Domains (1) summary

cl21584
Location:40 → 171

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...