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    Popdc3 popeye domain containing 3 [ Mus musculus (house mouse) ]

    Gene ID: 78977, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Popdc3provided by MGI
    Official Full Name
    popeye domain containing 3provided by MGI
    Primary source
    MGI:MGI:1930153
    See related
    Ensembl:ENSMUSG00000019848 AllianceGenome:MGI:1930153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pop3
    Summary
    Enables cAMP binding activity. Acts upstream of or within regulation of membrane potential. Located in membrane. Is expressed in several structures, including gut; heart; leg muscle; male reproductive gland or organ; and nervous system. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human POPDC3 (popeye domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in heart adult (RPKM 5.6), bladder adult (RPKM 2.7) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Popdc3 in Genome Data Viewer
    Location:
    10 B2; 10 23.35 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (45165401..45194546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (45289305..45318450)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26567 Neighboring gene STARR-seq mESC enhancer starr_26571 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:44823099-44823208 Neighboring gene prolyl endopeptidase Neighboring gene STARR-seq mESC enhancer starr_26573 Neighboring gene STARR-seq mESC enhancer starr_26574 Neighboring gene VISTA enhancer mm87 Neighboring gene STARR-seq mESC enhancer starr_26575 Neighboring gene predicted gene, 26016 Neighboring gene predicted gene 15934 Neighboring gene STARR-seq mESC enhancer starr_26577 Neighboring gene blood vessel epicardial substance Neighboring gene STARR-seq mESC enhancer starr_26578 Neighboring gene lin-28 homolog B Neighboring gene predicted gene, 51827

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression. Matsubara S, et al. Gene, 2010 Oct 1. PMID 20600704
    2. Mouse Pop1 is required for muscle regeneration in adult skeletal muscle. Andrée B, et al. Mol Cell Biol, 2002 Mar. PMID 11839816, Free PMC Article
    3. Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice. Froese A, et al. J Clin Invest, 2012 Mar. PMID 22354168, Free PMC Article
    4. Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart. Andrée B, et al. Dev Biol, 2000 Jul 15. PMID 10882522
    5. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC141238

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cAMP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in striated muscle cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    popeye domain-containing protein 3
    Names
    popeye 3
    popeye protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024286.1 → NP_077248.1  popeye domain-containing protein 3

      See identical proteins and their annotated locations for NP_077248.1

      Status: VALIDATED

      Source sequence(s)
      AK052325
      Consensus CDS
      CCDS23827.1
      UniProtKB/Swiss-Prot
      Q1RME0, Q9ES81
      Related
      ENSMUSP00000019994.8, ENSMUST00000019994.14
      Conserved Domains (1) summary
      pfam04831
      Location:25 → 249
      Popeye; Popeye protein conserved region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      45165401..45194546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512931.5 → XP_006512994.1  popeye domain-containing protein 3 isoform X2

      Conserved Domains (1) summary
      pfam04831
      Location:34 → 196
      Popeye; Popeye protein conserved region

    2. XM_036156114.1 → XP_036012007.1  popeye domain-containing protein 3 isoform X1

      UniProtKB/Swiss-Prot
      Q1RME0, Q9ES81
      Conserved Domains (1) summary
      pfam04831
      Location:25 → 249
      Popeye; Popeye protein conserved region
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES81.1 GenPept UniProtKB/Swiss-Prot:Q9ES81

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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