Fitm2 fat storage-inducing transmembrane protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fitm2provided by MGI
Official Full Name: fat storage-inducing transmembrane protein 2provided by MGI
Primary source: MGI:MGI:2444508
See related: Ensembl:ENSMUSG00000048486 AllianceGenome:MGI:2444508
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fit2; D930001I22Rik
Summary: Enables diacylglycerol binding activity and triglyceride binding activity. Involved in several processes, including intracellular triglyceride homeostasis; lipid droplet formation; and positive regulation of sequestering of triglyceride. Acts upstream of or within sequestering of triglyceride. Located in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and integumental system. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM2 (fat storage inducing transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 53.0), adrenal adult (RPKM 50.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 84.29 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (163310623..163314549, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (163468703..163472629, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fitm2 is required for ER homeostasis and normal function of murine liver.
Title: Fitm2 is required for ER homeostasis and normal function of murine liver.
Destabilization of beta Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
Title: Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes.
The results suggest that Mouse (Mus musculus) fat storage-inducing transmembrane protein 2 (MmFIT2) recruits sesquiterpene synthetic machinery to endoplasmic reticulum (ER) subdomains involved in lipid droplet (LD) formation and that this process can enhance the efficiency of sesquiterpene biosynthesis and compartmentalization in plant cells.
Title: Mouse lipogenic proteins promote the co-accumulation of triacylglycerols and sesquiterpenes in plant cells.
data support the conclusion that FIT2 plays an essential role in regulating intestinal health and survival postnatally
Title: Postnatal Deletion of Fat Storage-inducing Transmembrane Protein 2 (FIT2/FITM2) Causes Lethal Enteropathy.
These data support the conclusion that FIT2 plays an essential, physiological role in fat storage in vivo.
Title: Fat storage-inducing transmembrane protein 2 is required for normal fat storage in adipose tissue.
Findings indicate that lipid droplet (LD)produced by storage-inducing transmembrane proteins 2 (FIT2) were approximately 80% larger than storage-inducing transmembrane proteins 1 (FIT1).
Title: Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.
FIT2 expression in skeletal muscle plays an unexpected function in regulating muscle energy metabolism and indicates an important role for lipid droplet formation in this process
Title: Re-patterning of skeletal muscle energy metabolism by fat storage-inducing transmembrane protein 2.
FIT2 is a 6 transmembrane domain-containing protein whose conformation likely regulates its activity in mediating lipid droplet formation.
Title: Structural insights into triglyceride storage mediated by fat storage-inducing transmembrane (FIT) protein 2.
FIT1 and FIT2 are endoplasmic reticulum resident membrane proteins that induce lipid droplet accumulation in cell culture and when expressed in mouse liver.
Title: Evolutionarily conserved gene family important for fat storage.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables coenzyme A diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables coenzyme A diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables diacylglycerol binding	IDA Inferred from Direct Assay more info	PubMed
enables triglyceride binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty-acyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty-acyl-CoA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet formation	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid droplet formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid droplet formation	ISO Inferred from Sequence Orthology more info
involved_in lipid droplet organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid droplet organization	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid droplet organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid storage	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of sequestering of triglyceride	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of triglyceride biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sequestering of triglyceride	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: acyl-coenzyme A diphosphatase FITM2

Names: fat-inducing protein 2; fat-inducing transcript 2

NP_775573.1

EC 3.6.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.