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    Kcnf1 potassium voltage-gated channel, subfamily F, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 382571, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kcnf1provided by MGI
    Official Full Name
    potassium voltage-gated channel, subfamily F, member 1provided by MGI
    Primary source
    MGI:MGI:2687399
    See related
    Ensembl:ENSMUSG00000051726 AllianceGenome:MGI:2687399
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv5.1; Gm1182
    Summary
    Predicted to enable potassium channel regulator activity. Involved in non-motile cilium assembly. Is active in ciliary base. Is expressed in several structures, including adipose tissue; bone; heart; lung; and spleen. Orthologous to human KCNF1 (potassium voltage-gated channel modifier subfamily F member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human all
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    Genomic context

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    See Kcnf1 in Genome Data Viewer
    Location:
    12 A1.1; 12 8.04 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (17222101..17226551, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (17172100..17176888, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31651 Neighboring gene STARR-positive B cell enhancer ABC_E7121 Neighboring gene solute carrier family 66 member 3 Neighboring gene STARR-positive B cell enhancer ABC_E11504 Neighboring gene ciliary microtubule inner protein 5 Neighboring gene STARR-seq mESC enhancer starr_31652 Neighboring gene STARR-seq mESC enhancer starr_31653 Neighboring gene STARR-seq mESC enhancer starr_31654 Neighboring gene predicted gene, 36568 Neighboring gene predicted gene 10054

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Screen-based identification and validation of four new ion channels as regulators of renal ciliogenesis. Slaats GG, et al. J Cell Sci, 2015 Dec 15. PMID 26546361, Free PMC Article
    2. Quantitative trait loci analysis reveals candidate genes implicated in regulating functional deficit and CNS vascular permeability in CD8 T cell-initiated blood-brain barrier disruption. Johnson HL, et al. BMC Genomics, 2013 Oct 3. PMID 24090483, Free PMC Article
    3. Ion channel expression in the developing enteric nervous system. Hirst CS, et al. PLoS One, 2015. PMID 25798587, Free PMC Article
    4. Osteoblast-specific expression of Panx3 is dispensable for postnatal bone remodeling. Yorgan TA, et al. Bone, 2019 Oct. PMID 31202927
    5. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Harrell MD, et al. Physiol Genomics, 2007 Feb 12. PMID 16985003

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC62472

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables potassium channel regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in non-motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in ciliary base IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    voltage-gated potassium channel regulatory subunit KCNF1
    Names
    voltage-gated potassium channel subunit Kv5.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_201531.5 → NP_963289.3  voltage-gated potassium channel regulatory subunit KCNF1

      Status: VALIDATED

      Source sequence(s)
      AC159312
      Consensus CDS
      CCDS25825.2
      UniProtKB/Swiss-Prot
      Q7TSH7
      Related
      ENSMUSP00000131480.3, ENSMUST00000170580.3
      Conserved Domains (2) summary
      cd18381
      Location:23 → 138
      BTB_POZ_Kv5_KCNF1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in KCNF/Kv5 subfamily of potassium voltage-gated channels
      pfam00520
      Location:181 → 417
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      17222101..17226551 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TSH7.1 GenPept UniProtKB/Swiss-Prot:Q7TSH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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