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    Rfx7 regulatory factor X, 7 [ Mus musculus (house mouse) ]

    Gene ID: 319758, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rfx7provided by MGI
    Official Full Name
    regulatory factor X, 7provided by MGI
    Primary source
    MGI:MGI:2442675
    See related
    Ensembl:ENSMUSG00000037674 AllianceGenome:MGI:2442675
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rfxdc2; 2510005N23Rik; 9930116O05Rik; D130086K05Rik
    Summary
    Enables RNA polymerase II core promoter sequence-specific DNA binding activity. Involved in positive regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human RFX7 (regulatory factor X7). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 7.8), CNS E14 (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rfx7 in Genome Data Viewer
    Location:
    9 D; 9 40.08 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (72439346..72530231)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (72532169..72622949)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5084 Neighboring gene meiosis-specific nuclear structural protein 1 Neighboring gene testis expressed gene 9 Neighboring gene predicted gene, 33004 Neighboring gene RIKEN cDNA 4930509E16 gene Neighboring gene STARR-positive B cell enhancer ABC_E8299 Neighboring gene STARR-positive B cell enhancer ABC_E5085 Neighboring gene 60S ribosomal protein L38 pseudogene Neighboring gene ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_24596 Neighboring gene VISTA enhancer mm1473 Neighboring gene predicted gene, 23057 Neighboring gene STARR-positive B cell enhancer ABC_E893 Neighboring gene neural precursor cell expressed, developmentally down-regulated 4 Neighboring gene STARR-seq mESC enhancer starr_24604 Neighboring gene STARR-positive B cell enhancer ABC_E6764

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Liang S, et al. Mol Vis, 2004 Oct 8. PMID 15496829
    2. The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity. Castro W, et al. Nat Immunol, 2018 Aug. PMID 29967452, Free PMC Article
    3. Gene expression in the developing mouse retina by EST sequencing and microarray analysis. Mu X, et al. Nucleic Acids Res, 2001 Dec 15. PMID 11812828, Free PMC Article
    4. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that Rfx7 is a novel transcriptional regulator of NK cell homeostasis and metabolic quiescence
      Title: The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding protein RFX7
    Names
    regulatory factor X domain containing 2 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033536.1 → NP_001028708.1  DNA-binding protein RFX7

      See identical proteins and their annotated locations for NP_001028708.1

      Status: VALIDATED

      Source sequence(s)
      AC111135, AC123683, AK090370, CK638728, CN537334
      Consensus CDS
      CCDS40686.1
      UniProtKB/Swiss-Prot
      F8VPJ6
      Related
      ENSMUSP00000127192.2, ENSMUST00000163401.9
      Conserved Domains (3) summary
      pfam05109
      Location:330 → 668
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02257
      Location:105 → 181
      RFX_DNA_binding; RFX DNA-binding domain
      pfam18326
      Location:43 → 100
      RFX5_N; RFX5 N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      72439346..72530231
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242754.4 → XP_011241056.1  DNA-binding protein RFX7 isoform X1

      See identical proteins and their annotated locations for XP_011241056.1

      UniProtKB/Swiss-Prot
      F8VPJ6
      Conserved Domains (3) summary
      pfam05109
      Location:330 → 668
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02257
      Location:105 → 181
      RFX_DNA_binding; RFX DNA-binding domain
      pfam18326
      Location:43 → 100
      RFX5_N; RFX5 N-terminal domain

    2. XM_006511223.5 → XP_006511286.1  DNA-binding protein RFX7 isoform X1

      See identical proteins and their annotated locations for XP_006511286.1

      UniProtKB/Swiss-Prot
      F8VPJ6
      Conserved Domains (3) summary
      pfam05109
      Location:330 → 668
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam02257
      Location:105 → 181
      RFX_DNA_binding; RFX DNA-binding domain
      pfam18326
      Location:43 → 100
      RFX5_N; RFX5 N-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F8VPJ6.1 GenPept UniProtKB/Swiss-Prot:F8VPJ6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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