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    SLC16A4 solute carrier family 16 member 4 [ Homo sapiens (human) ]

    Gene ID: 9122, updated on 14-Nov-2024

    Summary

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    Official Symbol
    SLC16A4provided by HGNC
    Official Full Name
    solute carrier family 16 member 4provided by HGNC
    Primary source
    HGNC:HGNC:10925
    See related
    Ensembl:ENSG00000168679 MIM:603878; AllianceGenome:HGNC:10925
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MCT4; MCT5
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in kidney (RPKM 44.3), placenta (RPKM 12.3) and 10 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SLC16A4 in Genome Data Viewer
    Location:
    1p13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (110362857..110391026, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (110377933..110406181, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110905479..110933648, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RBM15 antisense RNA 1 Neighboring gene uncharacterized LOC124904276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1173 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:110882428-110883166 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:110883828-110884393 Neighboring gene RNA binding motif protein 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1471 Neighboring gene LAMTOR5 and SLC16A4 antisense RNA 1 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1174 Neighboring gene prokineticin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Monocarboxylate transporter 4, associated with the acidification of synovial fluid, is a novel therapeutic target for inflammatory arthritis. Fujii W, et al. Arthritis Rheumatol, 2015 Nov. PMID 26213210
    2. Benign albeit glycolytic: MCT4 expression and lactate release in giant cell tumour of bone. Avnet S, et al. Bone, 2020 May. PMID 32112988
    3. Role of monocarboxylate transporter 4 in Alzheimer disease. Hong P, et al. Neurotoxicology, 2020 Jan. PMID 31738978
    4. Monocarboxylate Transporter 4 (MCT4) Overexpression Is Correlated with Poor Prognosis of Osteosarcoma. Liu Y, et al. Med Sci Monit, 2019 Jun 9. PMID 31177263, Free PMC Article
    5. Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer. Todenhöfer T, et al. Mol Cancer Ther, 2018 Dec. PMID 30262589

    See all (122) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
      Title: Macrophage MCT4 inhibition activates reparative genes and protects from atherosclerosis by histone H3 lysine 18 lactylation.
    2. MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells.
      Title: MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells.
    3. SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma.
      Title: SYVN1-mediated ubiquitylation directs localization of MCT4 in the plasma membrane to promote the progression of lung adenocarcinoma.
    4. Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
      Title: Immunohistochemical evaluation and prognostic value of monocarboxylate transporter 1 (MCT1) and 4 (MCT4) in T-cell non-Hodgkin lymphoma.
    5. Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta.
      Title: Maternal obesity-associated disruption of polarized lactate transporter MCT4 expression in human placenta.
    6. GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.
      Title: GLUT1, LDHA, and MCT4 Expression Is Deregulated in Cervical Cancer and Precursor Lesions.
    7. TGF-beta1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation.
      Title: TGF-β1 induced autophagy in cancer associated fibroblasts during hypoxia contributes EMT and glycolysis via MCT4 upregulation.
    8. TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
      Title: TRIM72 exerts antitumor effects in breast cancer and modulates lactate production and MCT4 promoter activity by interacting with PPP3CA.
    9. Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
      Title: Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
    10. ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer.
      Title: ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (104)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carboxylic acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monocarboxylic acid transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    monocarboxylate transporter 5
    Names
    MCT 4
    MCT 5
    monocarboxylate transporter 4
    solute carrier family 16 (monocarboxylic acid transporters), member 4
    solute carrier family 16, member 4 (monocarboxylic acid transporter 5)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201546.2 → NP_001188475.1  monocarboxylate transporter 5 isoform 2

      See identical proteins and their annotated locations for NP_001188475.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to variant 1.
      Source sequence(s)
      AI245349, AK290720, AL833619, BP345760, U59185
      Consensus CDS
      CCDS55623.1
      UniProtKB/TrEMBL
      Q53FH9
      Related
      ENSP00000432495.1, ENST00000472422.6
      Conserved Domains (1) summary
      cl26868
      Location:16 → 426
      2A0111; oxalate/formate antiporter family transporter

    2. NM_001201547.2 → NP_001188476.1  monocarboxylate transporter 5 isoform 3

      See identical proteins and their annotated locations for NP_001188476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate exon in the coding region which results in the use of a downstream start codon initially in a different reading frame, compared to variant 1. The resulting protein (isoform 3) has a shorter and distinct N-terminus yet matches most of the protein when it is compared to isoform 1.
      Source sequence(s)
      AI245349, AK295946, BE893159, U59185
      Consensus CDS
      CCDS55622.1
      UniProtKB/TrEMBL
      Q53FH9
      Related
      ENSP00000446087.1, ENST00000541986.5
      Conserved Domains (1) summary
      cd06174
      Location:8 → 415
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    3. NM_001201548.2 → NP_001188477.1  monocarboxylate transporter 5 isoform 4

      See identical proteins and their annotated locations for NP_001188477.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate exons in the coding region which results in the use of a downstream start codon initially in a different reading frame, compared to variant 1. The resulting protein (isoform 4) has a shorter and distinct N-terminus yet matches most of the protein when it is compared to isoform 1.
      Source sequence(s)
      AI245349, AK298539, U59185
      Consensus CDS
      CCDS55621.1
      UniProtKB/TrEMBL
      A0A1S5UZI1
      Related
      ENSP00000394790.2, ENST00000437429.6
      Conserved Domains (1) summary
      cl26868
      Location:6 → 335
      2A0111; oxalate/formate antiporter family transporter

    4. NM_001201549.2 → NP_001188478.1  monocarboxylate transporter 5 isoform 5

      See identical proteins and their annotated locations for NP_001188478.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate, in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to variant 1.
      Source sequence(s)
      AI245349, BC021664, BP345760, U59185
      Consensus CDS
      CCDS55624.1
      UniProtKB/Swiss-Prot
      O15374
      Related
      ENSP00000358796.4, ENST00000369781.8
      Conserved Domains (1) summary
      cl26868
      Location:16 → 306
      2A0111; oxalate/formate antiporter family transporter

    5. NM_001319220.2 → NP_001306149.1  monocarboxylate transporter 5 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks two alternate exons compared to variant 1. The resulting isoform (6) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1.
      Source sequence(s)
      AI245349, AL355488, BX647948
      Conserved Domains (2) summary
      cd06174
      Location:143 → 249
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00892
      Location:12 → 244
      2A0113; monocarboxylate transporter 1

    6. NM_004696.3 → NP_004687.1  monocarboxylate transporter 5 isoform 1

      See identical proteins and their annotated locations for NP_004687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AI245349, AK313735, U59185
      Consensus CDS
      CCDS823.1
      UniProtKB/Swiss-Prot
      A8K3V5, B2R9C9, B4DJ67, B4DPX7, E7EPY8, G3V175, O15374, Q5T612, Q8WU09
      UniProtKB/TrEMBL
      Q53FH9
      Related
      ENSP00000358794.4, ENST00000369779.9
      Conserved Domains (2) summary
      cd06174
      Location:24 → 477
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:27 → 442
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      110362857..110391026 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711033.4 → XP_006711096.1  monocarboxylate transporter 5 isoform X3

      See identical proteins and their annotated locations for XP_006711096.1

      UniProtKB/TrEMBL
      A0A1S5UZI1
      Conserved Domains (1) summary
      cd06174
      Location:183 → 367
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

    2. XM_047433986.1 → XP_047289942.1  monocarboxylate transporter 5 isoform X5

    3. XM_047433990.1 → XP_047289946.1  monocarboxylate transporter 5 isoform X6

    4. XM_047433967.1 → XP_047289923.1  monocarboxylate transporter 5 isoform X2

    5. XM_047433980.1 → XP_047289936.1  monocarboxylate transporter 5 isoform X4

    6. XM_005271317.6 → XP_005271374.1  monocarboxylate transporter 5 isoform X1

      See identical proteins and their annotated locations for XP_005271374.1

      UniProtKB/Swiss-Prot
      A8K3V5, B2R9C9, B4DJ67, B4DPX7, E7EPY8, G3V175, O15374, Q5T612, Q8WU09
      UniProtKB/TrEMBL
      Q53FH9
      Conserved Domains (2) summary
      cd06174
      Location:24 → 477
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:27 → 442
      MFS_1; Major Facilitator Superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      110377933..110406181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339556.1 → XP_054195531.1  monocarboxylate transporter 5 isoform X3

    2. XM_054339558.1 → XP_054195533.1  monocarboxylate transporter 5 isoform X5

    3. XM_054339559.1 → XP_054195534.1  monocarboxylate transporter 5 isoform X6

    4. XM_054339555.1 → XP_054195530.1  monocarboxylate transporter 5 isoform X2

    5. XM_054339557.1 → XP_054195532.1  monocarboxylate transporter 5 isoform X4

    6. XM_054339554.1 → XP_054195529.1  monocarboxylate transporter 5 isoform X1

      UniProtKB/Swiss-Prot
      A8K3V5, B2R9C9, B4DJ67, B4DPX7, E7EPY8, G3V175, O15374, Q5T612, Q8WU09
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O15374.1 GenPept UniProtKB/Swiss-Prot:O15374

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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