U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Aloxe3 arachidonate lipoxygenase 3 [ Mus musculus (house mouse) ]

    Gene ID: 23801, updated on 2-Nov-2024

    Summary

    Official Symbol
    Aloxe3provided by MGI
    Official Full Name
    arachidonate lipoxygenase 3provided by MGI
    Primary source
    MGI:MGI:1345140
    See related
    Ensembl:ENSMUSG00000020892 AllianceGenome:MGI:1345140
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    eLOX-3; e-LOX-3
    Summary
    Enables hepoxilin A3 synthase activity. Involved in several processes, including establishment of skin barrier; long-chain fatty acid metabolic process; and peroxisome proliferator activated receptor signaling pathway. Predicted to be located in cytoplasm. Is expressed in epidermis and skin. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and autosomal recessive congenital ichthyosis 3. Orthologous to human ALOXE3 (arachidonate epidermal lipoxygenase 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in stomach adult (RPKM 6.6), CNS E18 (RPKM 2.7) and 10 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Aloxe3 in Genome Data Viewer
    Location:
    11 B3; 11 42.38 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (69016243..69039941)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (69125417..69149115)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2995 Neighboring gene nuclear encoded tRNA lysine 27 (anticodon TTT) Neighboring gene nuclear encoded tRNA glutamine 6 (anticodon CTG) Neighboring gene arachidonate 12-lipoxygenase, 12R type Neighboring gene arachidonate 8-lipoxygenase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC143829, MGC143830

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    NOT involved_in bicellular tight junction assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ceramide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hepoxilin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in hepoxilin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in hepoxilin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hepoxilin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in linoleic acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid oxidation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipoxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoxygenase pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peroxisome proliferator activated receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sensory perception of pain ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sensory perception of pain ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in sphingolipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sphingolipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    hydroperoxide isomerase ALOXE3
    Names
    epidermal LOX-3
    epidermis-type lipoxygenase 3
    hydroperoxy dehydratase ALOXE3
    hydroperoxy icosatetraenoate dehydratase
    hydroperoxy icosatetraenoate isomerase
    NP_035916.2
    XP_030101841.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011786.2NP_035916.2  hydroperoxide isomerase ALOXE3

      See identical proteins and their annotated locations for NP_035916.2

      Status: VALIDATED

      Source sequence(s)
      AK141003, AL645527, BC116259
      Consensus CDS
      CCDS24884.1
      UniProtKB/Swiss-Prot
      B1ASX3, Q9WV07
      UniProtKB/TrEMBL
      Q14B96
      Related
      ENSMUSP00000021268.3, ENSMUST00000021268.9
      Conserved Domains (2) summary
      cd01753
      Location:2116
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:268702
      Lipoxygenase; Lipoxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      69016243..69039941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245981.1XP_030101841.1  hydroperoxide isomerase ALOXE3 isoform X1

      Conserved Domains (1) summary
      pfam00305
      Location:38472
      Lipoxygenase

    RNA

    1. XR_388452.5 RNA Sequence

    2. XR_004936957.1 RNA Sequence

    3. XR_004936956.1 RNA Sequence

    4. XR_003949436.1 RNA Sequence

    5. XR_004936955.1 RNA Sequence

    6. XR_388449.3 RNA Sequence

    7. XR_003949435.1 RNA Sequence

    8. XR_003949437.1 RNA Sequence