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    Lrrc58 leucine rich repeat containing 58 [ Mus musculus (house mouse) ]

    Gene ID: 320184, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Lrrc58provided by MGI
    Official Full Name
    leucine rich repeat containing 58provided by MGI
    Primary source
    MGI:MGI:2443542
    See related
    Ensembl:ENSMUSG00000034158 AllianceGenome:MGI:2443542
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810012N18Rik; C330018J07Rik
    Summary
    Predicted to be involved in intracellular signal transduction. Orthologous to human LRRC58 (leucine rich repeat containing 58). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 37.6), subcutaneous fat pad adult (RPKM 32.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc58 in Genome Data Viewer
    Location:
    16 B3; 16 26.49 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (37688762..37709219)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (37868400..37888857)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene follistatin-like 1 Neighboring gene STARR-seq mESC enhancer starr_40798 Neighboring gene predicted gene, 41452 Neighboring gene butyrophilin-like 12 Neighboring gene VISTA enhancer mm1361 Neighboring gene actin, beta, cytoplasmic (Actb) pseudogene Neighboring gene STARR-seq mESC enhancer starr_40799 Neighboring gene G protein-coupled receptor 156 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:37963429-37963630 Neighboring gene predicted gene, 36225 Neighboring gene predicted gene, 25140 Neighboring gene STARR-seq mESC enhancer starr_40800 Neighboring gene RIKEN cDNA 4930542C21 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Murn J, et al. Genes Dev, 2015 Mar 1. PMID 25737280, Free PMC Article
    2. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 58

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177093.3 → NP_796067.2  leucine-rich repeat-containing protein 58

      See identical proteins and their annotated locations for NP_796067.2

      Status: VALIDATED

      Source sequence(s)
      AC161268, AK049274
      Consensus CDS
      CCDS37340.1
      UniProtKB/Swiss-Prot
      B2RU81, Q3UGP9, Q8BX06
      Related
      ENSMUSP00000077779.7, ENSMUST00000078717.7
      Conserved Domains (3) summary
      cd00116
      Location:54 → 206
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:65 → 87
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:161 → 219
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      37688762..37709219
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UGP9.1 GenPept UniProtKB/Swiss-Prot:Q3UGP9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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