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    Cmpk1 cytidine/uridine monophosphate kinase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66588, updated on 14-Nov-2024

    Summary

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    Official Symbol
    Cmpk1provided by MGI
    Official Full Name
    cytidine/uridine monophosphate kinase 1provided by MGI
    Primary source
    MGI:MGI:1913838
    See related
    Ensembl:ENSMUSG00000028719 AllianceGenome:MGI:1913838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CK; Cmpk; UMP-CMPk; 0610011D08Rik
    Summary
    Predicted to enable CMP kinase activity; UMP kinase activity; and nucleoside diphosphate kinase activity. Predicted to be involved in pyrimidine nucleoside diphosphate biosynthetic process. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including heart; nervous system; respiratory system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 43.9), colon adult (RPKM 37.4) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cmpk1 in Genome Data Viewer
    Location:
    4 D1; 4 52.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (114817810..114844425, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (114960613..114987228, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene forkhead box E3 Neighboring gene STARR-positive B cell enhancer mm9_chr4:114620034-114620334 Neighboring gene predicted gene, 40229 Neighboring gene STARR-positive B cell enhancer ABC_E2705 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:114672416-114672599 Neighboring gene STARR-seq mESC enhancer starr_11107 Neighboring gene Scl/Tal1 interrupting locus Neighboring gene predicted gene, 52674

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Liou JY, et al. Cancer Res, 2002 Mar 15. PMID 11912132
    2. A protein interaction network for the large conductance Ca(2+)-activated K(+) channel in the mouse cochlea. Kathiresan T, et al. Mol Cell Proteomics, 2009 Aug. PMID 19423573, Free PMC Article
    3. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables (d)CMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables UMP kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables UMP/dUMP kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dCMP kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleoside diphosphate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleoside monophosphate kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' pyrimidine nucleobase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in CDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in CDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in UDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in UDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in dCDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dUDP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    UMP-CMP kinase
    Names
    UMP/CMPK
    cytidine monophosphate (UMP-CMP) kinase 1
    cytidine monophosphate kinase
    cytidylate kinase 1
    dCMP kinase
    deoxycytidylate kinase
    likely ortholog of H. sapiens UMP-CMP kinase (UMP-CMPK)
    nucleoside-diphosphate kinase
    uridine monophosphate kinase
    uridine monophosphate/cytidine monophosphate kinase
    NP_079923.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025647.3 → NP_079923.3  UMP-CMP kinase

      See identical proteins and their annotated locations for NP_079923.3

      Status: VALIDATED

      Source sequence(s)
      AK002526, AK077534, AK150162, AV315242
      Consensus CDS
      CCDS18484.1
      UniProtKB/Swiss-Prot
      Q8BK17, Q8VD05, Q9DBP5, Q9DCS7
      UniProtKB/TrEMBL
      A0A0R4J093
      Related
      ENSMUSP00000030491.9, ENSMUST00000030491.9
      Conserved Domains (2) summary
      cd01428
      Location:36 → 215
      ADK; Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for ...
      TIGR01359
      Location:36 → 224
      UMP_CMP_kin_fam; UMP-CMP kinase family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      114817810..114844425 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBP5.1 GenPept UniProtKB/Swiss-Prot:Q9DBP5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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