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    Arhgef33 Rho guanine nucleotide exchange factor 33 [ Mus musculus (house mouse) ]

    Gene ID: 381112, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Arhgef33provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 33provided by MGI
    Primary source
    MGI:MGI:2685787
    See related
    Ensembl:ENSMUSG00000054901 AllianceGenome:MGI:2685787
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm941
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Orthologous to human ARHGEF33 (Rho guanine nucleotide exchange factor 33). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 8.0) and testis adult (RPKM 1.4) See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef33 in Genome Data Viewer
    Location:
    17 E3; 17 50.63 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80614354..80740926)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80306923..80433497)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene DExH-box helicase 57 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene MORN repeat containing 2 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190 Neighboring gene STARR-seq mESC enhancer starr_43312 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1 Neighboring gene STARR-seq mESC enhancer starr_43313 Neighboring gene STARR-positive B cell enhancer ABC_E8924 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene alkaline phosphatase, intestinal pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. Hall EA, et al. Am J Hum Genet, 2017 May 4. PMID 28413018, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 33
    Names
    DH and coiled-coil domain-containing protein ENSP00000381780 homolog
    Rho guanine nucleotide exchange factor (GEF) 33

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145452.1 → NP_001138924.1  rho guanine nucleotide exchange factor 33

      See identical proteins and their annotated locations for NP_001138924.1

      Status: PROVISIONAL

      Source sequence(s)
      AC161447, AI848431, AK053944, BB628974, BE653884, BE654086, BE950677, CK793318, CK793330
      Consensus CDS
      CCDS50189.1
      UniProtKB/Swiss-Prot
      Q8BW86
      Related
      ENSMUSP00000063284.6, ENSMUST00000068175.6
      Conserved Domains (1) summary
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      80614354..80740926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524512.5 → XP_006524575.1  rho guanine nucleotide exchange factor 33 isoform X3

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:259 → 426
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    2. XM_030249876.2 → XP_030105736.1  rho guanine nucleotide exchange factor 33 isoform X4

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:259 → 426
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    3. XM_030249875.2 → XP_030105735.1  rho guanine nucleotide exchange factor 33 isoform X3

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:259 → 426
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    4. XM_006524509.4 → XP_006524572.1  rho guanine nucleotide exchange factor 33 isoform X1

      See identical proteins and their annotated locations for XP_006524572.1

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    5. XM_006524511.4 → XP_006524574.1  rho guanine nucleotide exchange factor 33 isoform X2

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    6. XM_006524510.4 → XP_006524573.1  rho guanine nucleotide exchange factor 33 isoform X1

      See identical proteins and their annotated locations for XP_006524573.1

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    7. XM_006524514.5 → XP_006524577.1  rho guanine nucleotide exchange factor 33 isoform X7

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    8. XM_006524515.5 → XP_006524578.1  rho guanine nucleotide exchange factor 33 isoform X8

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    9. XM_030249880.2 → XP_030105740.1  rho guanine nucleotide exchange factor 33 isoform X9

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    10. XM_006524516.5 → XP_006524579.1  rho guanine nucleotide exchange factor 33 isoform X9

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    11. XM_006524519.5 → XP_006524582.1  rho guanine nucleotide exchange factor 33 isoform X10

      See identical proteins and their annotated locations for XP_006524582.1

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    12. XM_006524518.5 → XP_006524581.1  rho guanine nucleotide exchange factor 33 isoform X10

      See identical proteins and their annotated locations for XP_006524581.1

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    13. XM_006524513.5 → XP_006524576.1  rho guanine nucleotide exchange factor 33 isoform X5

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    14. XM_017317545.3 → XP_017173034.1  rho guanine nucleotide exchange factor 33 isoform X11

      UniProtKB/Swiss-Prot
      Q8BW86
      Conserved Domains (1) summary
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    15. XM_030249877.2 → XP_030105737.1  rho guanine nucleotide exchange factor 33 isoform X6

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    16. XM_030249879.2 → XP_030105739.1  rho guanine nucleotide exchange factor 33 isoform X6

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    17. XM_006524523.5 → XP_006524586.1  rho guanine nucleotide exchange factor 33 isoform X11

      See identical proteins and their annotated locations for XP_006524586.1

      UniProtKB/Swiss-Prot
      Q8BW86
      Conserved Domains (1) summary
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    18. XM_006524520.5 → XP_006524583.1  rho guanine nucleotide exchange factor 33 isoform X10

      See identical proteins and their annotated locations for XP_006524583.1

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    19. XM_006524524.5 → XP_006524587.1  rho guanine nucleotide exchange factor 33 isoform X11

      See identical proteins and their annotated locations for XP_006524587.1

      UniProtKB/Swiss-Prot
      Q8BW86
      Conserved Domains (1) summary
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    20. XM_006524522.5 → XP_006524585.1  rho guanine nucleotide exchange factor 33 isoform X12

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    21. XM_011246520.4 → XP_011244822.1  rho guanine nucleotide exchange factor 33 isoform X13

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    22. XM_006524525.5 → XP_006524588.1  rho guanine nucleotide exchange factor 33 isoform X14

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.

    23. XM_030249883.2 → XP_030105743.1  rho guanine nucleotide exchange factor 33 isoform X15

      Conserved Domains (2) summary
      pfam07111
      Location:42 → 127
      HCR; Alpha helical coiled-coil rod protein (HCR)
      cl02571
      Location:277 → 444
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BW86.3 GenPept UniProtKB/Swiss-Prot:Q8BW86

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