Commd3 COMM domain containing 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Commd3provided by MGI
Official Full Name: COMM domain containing 3provided by MGI
Primary source: MGI:MGI:88218
See related: Ensembl:ENSMUSG00000051154 AllianceGenome:MGI:88218
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bup; D2Ertd542e
Summary: Predicted to be involved in sodium ion transport. Predicted to be located in cytoplasm and nucleus. Is expressed in genitourinary system; pancreas; and submandibular gland primordium. Orthologous to human COMMD3 (COMM domain containing 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 46.7), CNS E14 (RPKM 37.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 12.9 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (18677246..18681042)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (18672435..18676231)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.
Title: COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:234331

AW550818 (e-PCR)
- UniSTS:178578

AU022527 (e-PCR)
- UniSTS:167331

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: COMM domain-containing protein 3

Names: Bmi1 upstream; bmi-1 upstream gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_147778.4 → NP_680087.1 COMM domain-containing protein 3

See identical proteins and their annotated locations for NP_680087.1

Status: VALIDATED

Source sequence(s)

AK041634, AK145999, BE950806

Consensus CDS

CCDS15710.1

UniProtKB/Swiss-Prot

A2ASR4, Q3UKI1, Q63829, Q8C9P5

Related

ENSMUSP00000049882.5, ENSMUST00000061158.5

Conserved Domains (1) summary

cd04751
Location:98 → 194

Commd3; COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...