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    TRIML2 tripartite motif family like 2 [ Homo sapiens (human) ]

    Gene ID: 205860, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TRIML2provided by HGNC
    Official Full Name
    tripartite motif family like 2provided by HGNC
    Primary source
    HGNC:HGNC:26378
    See related
    Ensembl:ENSG00000179046 MIM:620480; AllianceGenome:HGNC:26378
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPRYD6
    Summary
    This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
    Expression
    Biased expression in placenta (RPKM 2.0) and testis (RPKM 1.2) See more
    Orthologs
    mouse all
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    Genomic context

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    See TRIML2 in Genome Data Viewer
    Location:
    4q35.2
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (188091272..188109603, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (191438954..191457289, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (189012426..189030757, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900881 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr4:188894922-188895422 Neighboring gene peroxiredoxin 6 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188916113-188917092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188917093-188918074 Neighboring gene ZFP42 zinc finger protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188942947-188943484 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188953065-188953586 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:188953587-188954108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:188962925-188963778 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:189002377-189002958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189021213-189021714 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189027714-189028231 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189028751-189029269 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:189029270-189029788 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:189033421-189033938 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:189033939-189034456 Neighboring gene uncharacterized LOC107986337 Neighboring gene FAU pseudogene 3 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr4:189047967-189049166 Neighboring gene RNA, U6 small nuclear 173, pseudogene Neighboring gene tripartite motif family like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Association of tripartite motif family-like 2 (TRIML2) polymorphisms with late-onset Alzheimer's disease risk in a Korean population. Kang WS, et al. Neurosci Lett, 2016 Sep 6. PMID 27471163
    2. Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation. Zhang X, et al. Mol Biol Evol, 2020 Feb 1. PMID 31633784, Free PMC Article
    3. STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus. Gu F, et al. PLoS Pathog, 2018 Dec. PMID 30532138, Free PMC Article
    4. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. Kung CP, et al. Mol Cancer Res, 2015 Feb. PMID 25256710, Free PMC Article
    5. c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis. Feng YC, et al. Nat Commun, 2020 Oct 5. PMID 33020477, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.
      Title: Eutherian-Specific Gene TRIML2 Attenuates Inflammation in the Evolution of Placentation.
    2. the degradation of STAT6 is induced and required for the lytic activation of human herpesviruses and is association with the increased ubiquitylated form of TRIML2
      Title: STAT6 degradation and ubiquitylated TRIML2 are essential for activation of human oncogenic herpesvirus.
    3. Findings indicate that the C allele of two single nucleotide polymorphisms in the tripartite motif family-like 2 (TRIML2) gene was associated with an increased risk of Alzheimer disease (AD). These results suggest that TRIML2 may contribute to AD susceptibility.
      Title: Association of tripartite motif family-like 2 (TRIML2) polymorphisms with late-onset Alzheimer's disease risk in a Korean population.
    4. Data indicate that TRIML2 is part of a feed-forward loop that activates p53 in cells expressing the R72 variant, particularly after prolonged stress.
      Title: Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ25801, FLJ56315, MGC138164, MGC138166

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    probable E3 ubiquitin-protein ligase TRIML2
    Names
    RING-type E3 ubiquitin transferase TRIML2
    SPRY domain-containing protein 6
    tripartite motif family-like protein 2
    NP_001290348.1
    NP_775824.2
    XP_011530039.1
    XP_011530040.1
    XP_011530041.1
    XP_047305721.1
    XP_047305722.1
    XP_047305723.1
    XP_054205167.1
    XP_054205168.1
    XP_054205169.1
    XP_054205170.1
    XP_054205171.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001303419.1 → NP_001290348.1  probable E3 ubiquitin-protein ligase TRIML2 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AA729485, AC108073, AK300428, BC111959, BC143709, DA666390
      UniProtKB/TrEMBL
      J3KNI5
      Related
      ENSP00000317498.4, ENST00000326754.7
      Conserved Domains (1) summary
      cd13733
      Location:276 → 449
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    2. NM_173553.4 → NP_775824.2  probable E3 ubiquitin-protein ligase TRIML2 isoform 2

      See identical proteins and their annotated locations for NP_775824.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region compared to variant 1. This results in isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC108073, AK098667, AK300428, BC111959, DA666390, DC382432
      Consensus CDS
      CCDS3850.2
      UniProtKB/Swiss-Prot
      B7Z6J6, Q8N7C3
      UniProtKB/TrEMBL
      A0A804HJA0, J3KNI5
      Related
      ENSP00000507413.1, ENST00000682553.1
      Conserved Domains (3) summary
      COG1196
      Location:57 → 225
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13733
      Location:251 → 424
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cl00034
      Location:16 → 59
      Bbox_SF; B-box-type zinc finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      188091272..188109603 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011531738.3 → XP_011530040.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

      See identical proteins and their annotated locations for XP_011530040.1

      UniProtKB/Swiss-Prot
      B7Z6J6, Q8N7C3
      UniProtKB/TrEMBL
      A0A804HJA0, J3KNI5
      Conserved Domains (3) summary
      COG1196
      Location:57 → 225
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13733
      Location:251 → 424
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cl00034
      Location:16 → 59
      Bbox_SF; B-box-type zinc finger superfamily

    2. XM_047449767.1 → XP_047305723.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X5

    3. XM_011531737.3 → XP_011530039.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

      See identical proteins and their annotated locations for XP_011530039.1

      UniProtKB/Swiss-Prot
      B7Z6J6, Q8N7C3
      UniProtKB/TrEMBL
      A0A804HJA0, J3KNI5
      Related
      ENSP00000422581.2, ENST00000512729.5
      Conserved Domains (3) summary
      COG1196
      Location:57 → 225
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13733
      Location:251 → 424
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty
      cl00034
      Location:16 → 59
      Bbox_SF; B-box-type zinc finger superfamily

    4. XM_011531739.2 → XP_011530041.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

      UniProtKB/TrEMBL
      B7ZLC3
      Conserved Domains (1) summary
      cd13733
      Location:159 → 332
      SPRY_PRY_C-I_1; PRY/SPRY domain in tripartite motif-containing (TRIM) proteins, including TRIM5, TRIM6, TRIM7, TRIM10, TRIM11, TRIM17, TRIM20, TRIM21, TRIM27, TRIM35, TRIM38, TRIM41, TRIM50, TRIM58, TRIM60, TRIM62, TRIM69, TRIM72, NF7 and bloodthirsty

    5. XM_047449765.1 → XP_047305721.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X3

    6. XM_047449766.1 → XP_047305722.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      191438954..191457289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054349192.1 → XP_054205167.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z6J6, Q8N7C3
      UniProtKB/TrEMBL
      A0A804HJA0

    2. XM_054349193.1 → XP_054205168.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X1

      UniProtKB/Swiss-Prot
      B7Z6J6, Q8N7C3
      UniProtKB/TrEMBL
      A0A804HJA0

    3. XM_054349194.1 → XP_054205169.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X2

    4. XM_054349195.1 → XP_054205170.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X3

    5. XM_054349196.1 → XP_054205171.1  probable E3 ubiquitin-protein ligase TRIML2 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N7C3.2 GenPept UniProtKB/Swiss-Prot:Q8N7C3

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