MRGPRX4 MAS related GPR family member X4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MRGPRX4provided by HGNC
Official Full Name: MAS related GPR family member X4provided by HGNC
Primary source: HGNC:HGNC:17617
See related: Ensembl:ENSG00000179817 MIM:607230; AllianceGenome:HGNC:17617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPCR; MRGX4; SNSR6
Summary: Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within chemosensory behavior and hematopoietic progenitor cell differentiation. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: 11p15.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (18172837..18174280)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (18268336..18269779)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (18194384..18195827)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.
Title: MRGPRX4 mediates phospho-drug-associated pruritus in a humanized mouse model.
Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.
Title: Itch receptor MRGPRX4 interacts with the receptor activity-modifying proteins.
Structure, function and pharmacology of human itch GPCRs.
Title: Structure, function and pharmacology of human itch GPCRs.
MRGPRX4 in Cholestatic Pruritus.
Title: MRGPRX4 in Cholestatic Pruritus.
data support a model whereby both bile acids and bilirubin contribute to cholestatic itch via agonism at MRGPRX4
Title: MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.
Taken together, these data strongly suggest that MRGPRX4 is a novel bile acid receptor that likely underlies cholestatic itch in human, providing a promising new drug target for anti-itch therapies.
Title: MRGPRX4 is a bile acid receptor for human cholestatic itch.
data indicate that genetic variation in MRGPRX4 contributes to inter-individual and inter-ethnic differences in the preference for mentholated cigarettes.
Title: An African-specific haplotype in MRGPRX4 is associated with menthol cigarette smoking.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MRGX4__7298 (e-PCR)
- UniSTS:466342

NoName (e-PCR)
- UniSTS:484086

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: mas-related G-protein coupled receptor member X4

Names: G protein-coupled receptor MRGX4; G protein-coupled receptor SNSR5; G protein-coupled receptor SNSR6; MAS-related GPR, member X4; Mas-related G protein-coupled receptor X4; sensory neuron-specific G-protein coupled receptor 5/6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.