Tifab TRAF-interacting protein with forkhead-associated domain, family member B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tifabprovided by MGI
Official Full Name: TRAF-interacting protein with forkhead-associated domain, family member Bprovided by MGI
Primary source: MGI:MGI:2385852
See related: Ensembl:ENSMUSG00000049625 AllianceGenome:MGI:2385852
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables deubiquitinase activator activity. Acts upstream of with a negative effect on toll-like receptor signaling pathway. Acts upstream of or within several processes, including hemopoiesis; lipopolysaccharide-mediated signaling pathway; and regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator. Orthologous to human TIFAB (TIFA inhibitor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in spleen adult (RPKM 9.0), lung adult (RPKM 4.1) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 B1; 13 30.06 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (56318917..56326816, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (56173703..56179002, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms
Title: Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
TIFAB loss increases TRAF6 protein and the dynamic range of TLR4 signaling
Title: Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling.
study shows TIFAB is mainly expressed in B cells rather than T cells in the spleen; results suggest TIFAB could act as a negative regulator of TRAF6-induced cellular function such as B cell proliferation and maturation of dendritic cellss & macrophages
Title: TRAF-interacting protein with a forkhead-associated domain B (TIFAB) is a negative regulator of the TRAF6-induced cellular functions.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deubiquitinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in auditory behavior	IEA Inferred from Electronic Annotation more info
involved_in auditory behavior	ISO Inferred from Sequence Orthology more info
involved_in cochlea development	ISO Inferred from Sequence Orthology more info
involved_in cochlea morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cochlea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in craniofacial suture morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in craniofacial suture morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in genitalia development	ISO Inferred from Sequence Orthology more info
involved_in genitalia morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in hard palate morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in hard palate morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in learned vocalization behavior	IEA Inferred from Electronic Annotation more info
involved_in learned vocalization behavior	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mastication	IEA Inferred from Electronic Annotation more info
involved_in mastication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myeloid cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within myeloid cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of relaxation of muscle	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of relaxation of muscle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of saliva secretion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of saliva secretion	ISO Inferred from Sequence Orthology more info
involved_in neuromuscular process controlling balance	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular process controlling balance	ISO Inferred from Sequence Orthology more info
involved_in peristalsis	IEA Inferred from Electronic Annotation more info
involved_in peristalsis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of muscle organ development	IEA Inferred from Electronic Annotation more info
involved_in regulation of muscle organ development	ISO Inferred from Sequence Orthology more info
involved_in thorax and anterior abdomen determination	IEA Inferred from Electronic Annotation more info
involved_in thorax and anterior abdomen determination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_negative_effect toll-like receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trigeminal nerve development	IEA Inferred from Electronic Annotation more info
involved_in trigeminal nerve development	ISO Inferred from Sequence Orthology more info
involved_in vestibulocochlear nerve formation	IEA Inferred from Electronic Annotation more info
involved_in vestibulocochlear nerve formation	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TRAF-interacting protein with FHA domain-containing protein B

Names: TIFA like protein; TIFA related protein TIFAB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001168615.1 → NP_001162086.1 TRAF-interacting protein with FHA domain-containing protein B

See identical proteins and their annotated locations for NP_001162086.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC124395, AK153654, BY209244

Consensus CDS

CCDS26558.1

UniProtKB/Swiss-Prot

Q05DP7, Q571I3, Q8JZM6

Related

ENSMUSP00000152976.2, ENSMUST00000225063.2

Conserved Domains (1) summary

pfam00498
Location:37 → 107

FHA; FHA domain
NM_145976.4 → NP_666088.1 TRAF-interacting protein with FHA domain-containing protein B

See identical proteins and their annotated locations for NP_666088.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC124395, AK036643, BY209244

Consensus CDS

CCDS26558.1

UniProtKB/Swiss-Prot

Q05DP7, Q571I3, Q8JZM6

Related

ENSMUSP00000131162.2, ENSMUST00000169652.3

Conserved Domains (1) summary

pfam00498
Location:37 → 107

FHA; FHA domain