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    Mettl23 methyltransferase like 23 [ Mus musculus (house mouse) ]

    Gene ID: 74319, updated on 11-Nov-2024

    Summary

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    Official Symbol
    Mettl23provided by MGI
    Official Full Name
    methyltransferase like 23provided by MGI
    Primary source
    MGI:MGI:1921569
    See related
    Ensembl:ENSMUSG00000090266 AllianceGenome:MGI:1921569
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110005A03Rik; 1500035B17Rik; 4933424L15Rik
    Summary
    Enables histone H3R17 methyltransferase activity. Involved in epigenetic programming in the zygotic pronuclei. Acts upstream of with a positive effect on epigenetic programing of male pronucleus. Located in cytoplasm and female pronucleus. Is active in male pronucleus. Is expressed in embryo. Used to study glaucoma. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 44. Orthologous to human METTL23 (methyltransferase 23, arginine). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 16.8), mammary gland adult (RPKM 12.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mettl23 in Genome Data Viewer
    Location:
    11 E2; 11 81.49 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (116734341..116740566)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116843515..116849740)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:116644149-116644366 Neighboring gene matrix-remodelling associated 7 Neighboring gene STARR-seq mESC enhancer starr_31225 Neighboring gene STARR-positive B cell enhancer ABC_E7102 Neighboring gene STARR-positive B cell enhancer ABC_E4018 Neighboring gene STARR-positive B cell enhancer ABC_E2376 Neighboring gene jumonji domain containing 6 Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene serine and arginine-rich splicing factor 2 Neighboring gene STARR-seq mESC enhancer starr_31229 Neighboring gene mannoside acetylglucosaminyltransferase 5, isoenzyme B Neighboring gene predicted gene, 33829

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma. Pan Y, et al. J Clin Invest, 2022 Nov 1. PMID 36099048, Free PMC Article
    2. Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins. Hahn P, et al. BMC Genomics, 2008 Jun 18. PMID 18564434, Free PMC Article
    3. Histone H3 Methylated at Arginine 17 Is Essential for Reprogramming the Paternal Genome in Zygotes. Hatanaka Y, et al. Cell Rep, 2017 Sep 19. PMID 28930672
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma.
      Title: METTL23 mutation alters histone H3R17 methylation in normal-tension glaucoma.
    2. Located immediately downstream of Jmjd6, with a bi-directionar promoter between the two.
      Title: Genomic structure and expression of Jmjd6 and evolutionary analysis in the context of related JmjC domain containing proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heat shock protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone H3R17 methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3R17 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-arginine omega-N asymmetric methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cognition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect epigenetic programing of male pronucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epigenetic programming in the zygotic pronuclei IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epigenetic regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in female pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in male pronucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histone-arginine methyltransferase METTL23
    Names
    methyltransferase-like protein 23
    probable methyltransferase-like protein 23
    NP_083141.3
    XP_006534423.1
    XP_036012939.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_028865.3 → NP_083141.3  histone-arginine methyltransferase METTL23

      See identical proteins and their annotated locations for NP_083141.3

      Status: VALIDATED

      Source sequence(s)
      AK003450, AW490033, BY122329
      Consensus CDS
      CCDS25679.2
      UniProtKB/Swiss-Prot
      A2AA28, Q8R2Z2, Q9D1J5
      Related
      ENSMUSP00000101978.4, ENSMUST00000106370.10
      Conserved Domains (1) summary
      cl17173
      Location:63 → 189
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      116734341..116740566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534360.4 → XP_006534423.1  histone-arginine methyltransferase METTL23 isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:3 → 126
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    2. XM_036157046.1 → XP_036012939.1  histone-arginine methyltransferase METTL23 isoform X1

      Conserved Domains (1) summary
      cl17173
      Location:3 → 126
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2AA28.1 GenPept UniProtKB/Swiss-Prot:A2AA28

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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