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    Disp3 dispatched RND transporter family member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313705, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Disp3provided by RGD
    Official Full Name
    dispatched RND transporter family member 3provided by RGD
    Primary source
    RGD:1305820
    See related
    EnsemblRapid:ENSRNOG00000026447 AllianceGenome:RGD:1305820
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ptchd2; RGD1305820
    Summary
    Predicted to be involved in negative regulation of neuron differentiation; positive regulation of lipid metabolic process; and positive regulation of neural precursor cell proliferation. Predicted to be located in membrane. Predicted to be active in cytoplasm. Orthologous to human DISP3 (dispatched RND transporter family member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward (RPKM 27.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Disp3 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (163955160..164003980, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (158672015..158720806, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (165051522..165099826, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene F-box protein 2 Neighboring gene uncharacterized LOC108351059 Neighboring gene uncharacterized LOC102551951 Neighboring gene UbiA prenyltransferase domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DISP3 promotes proliferation and delays differentiation of neural progenitor cells. Zíková M, et al. FEBS Lett, 2014 Nov 3. PMID 25281927
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein dispatched homolog 3
    Names
    patched domain containing 2
    patched domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107992.2 → NP_001101462.2  protein dispatched homolog 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      D3ZW02
      Related
      ENSRNOP00000037381.6, ENSRNOT00000036647.8
      Conserved Domains (1) summary
      COG1033
      Location:375 → 572
      COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      163955160..164003980 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110097.2 → XP_038966025.1  protein dispatched homolog 3 isoform X1

      Conserved Domains (1) summary
      COG1033
      Location:375 → 572
      COG1033; Predicted exporter protein, RND superfamily [General function prediction only]

    RNA

    1. XR_005504461.2 RNA Sequence

    2. XR_005504462.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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