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    C1qa complement C1q A chain [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298566, updated on 2-Nov-2024

    Summary

    Official Symbol
    C1qaprovided by RGD
    Official Full Name
    complement C1q A chainprovided by RGD
    Primary source
    RGD:1306716
    See related
    EnsemblRapid:ENSRNOG00000012807 AllianceGenome:RGD:1306716
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adic
    Summary
    Involved in response to iron ion. Located in synapse. Biomarker of iron deficiency anemia. Human ortholog(s) of this gene implicated in glomerulonephritis. Orthologous to human C1QA (complement C1q A chain). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 2171.2), Liver (RPKM 544.2) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See C1qa in Genome Data Viewer
    Location:
    5q36
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (154417086..154419933, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149133635..149136482, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (155261254..155264101, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene complement C1q B chain Neighboring gene complement C1q C chain Neighboring gene uncharacterized LOC134487087 Neighboring gene Eph receptor A8

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC105755

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in astrocyte activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in astrocyte activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement activation, classical pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in complement-mediated synapse pruning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in complement-mediated synapse pruning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microglial cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microglial cell activation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neuron remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron remodeling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to iron ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in synapse organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in synapse pruning ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in vertebrate eye-specific patterning IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vertebrate eye-specific patterning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    part_of collagen trimer IEA
    Inferred from Electronic Annotation
    more info
     
    part_of complement component C1q complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of complement component C1q complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extrinsic component of postsynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extrinsic component of presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extrinsic component of presynaptic membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in postsynapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    complement C1q subcomponent subunit A
    Names
    adiponectin c
    complement component 1, q subcomponent, A chain
    complement component 1, q subcomponent, alpha polypeptide

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008515.1NP_001008515.1  complement C1q subcomponent subunit A precursor

      See identical proteins and their annotated locations for NP_001008515.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086605
      UniProtKB/Swiss-Prot
      P31720, Q5RJK1
      UniProtKB/TrEMBL
      A0A3B0J380, A6ITC6
      Related
      ENSRNOP00000017385.3, ENSRNOT00000017385.8
      Conserved Domains (2) summary
      smart00110
      Location:108244
      C1Q; Complement component C1q domain
      pfam01391
      Location:4096
      Collagen; Collagen triple helix repeat (20 copies)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      154417086..154419933 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)