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    Ptprk protein tyrosine phosphatase, receptor type, K [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360302, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ptprkprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Kprovided by RGD
    Primary source
    RGD:619706
    See related
    EnsemblRapid:ENSRNOG00000047605 AllianceGenome:RGD:619706
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Rptpk
    Summary
    Predicted to enable several functions, including beta-catenin binding activity; gamma-catenin binding activity; and protein tyrosine phosphatase activity. Involved in T cell differentiation; cell adhesion; and neuron projection development. Predicted to be located in several cellular components, including leading edge membrane; neuronal cell body; and photoreceptor outer segment. Orthologous to human PTPRK (protein tyrosine phosphatase receptor type K). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 161.2), Lung (RPKM 125.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptprk in Genome Data Viewer
    Location:
    1p12
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (18557091..19056297, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (16738896..17236687, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (17445052..18058266, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene thymocyte selection associated Neighboring gene antagonist of mitotic exit network 1, pseudogene 1 Neighboring gene autophagy related 4B, cysteine peptidase, pseudogene 1 Neighboring gene uncharacterized LOC120098804 Neighboring gene uncharacterized LOC120098806 Neighboring gene uncharacterized LOC134484965 Neighboring gene uncharacterized LOC120098805 Neighboring gene uncharacterized LOC134484966 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 4 Neighboring gene RuvB-like AAA ATPase 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat. Asano A, et al. Mamm Genome, 2007 Nov. PMID 17909891
    2. Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat. Iwata R, et al. Biomed Res, 2010 Feb. PMID 20203423
    3. Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats. Kose H, et al. Genomics, 2007 Jun. PMID 17434290
    4. A soluble version of the receptor-like protein tyrosine phosphatase kappa stimulates neurite outgrowth via a Grb2/MEK1-dependent signaling cascade. Drosopoulos NE, et al. Mol Cell Neurosci, 1999 Jun. PMID 10383829
    5. Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes. Xu Y, et al. J Biol Chem, 2006 Sep 15. PMID 16849327, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.
      Title: Contiguous gene deletion of Ptprk and Themis causes T-helper immunodeficiency (thid) in the LEC rat.
    2. The Ptprk gene is responsible for the thid mutation in the LEC rat. Results further suggest that RPTPkappa plays a critical role in the development of CD4 SP cells in the thymus.
      Title: A deletion mutation of the protein tyrosine phosphatase kappa (Ptprk) gene is responsible for T-helper immunodeficiency (thid) in the LEC rat.
    3. Ptprk appears to function in parallel with or downstream of Th-POK/cKrox (also known as ZBTB7B), a master regulator of T cell lineage decision.
      Title: Maturational arrest of thymocyte development is caused by a deletion in the receptor-like protein tyrosine phosphatase kappa gene in LEC rats.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in T cell differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to reactive oxygen species ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron projection development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein dephosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in leading edge membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in photoreceptor outer segment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    receptor-type tyrosine-protein phosphatase kappa
    Names
    protein tyrosine phosphatase, receptor type, K, extracellular region
    receptor-like protein tyrosine phosphatase kappa extracellular region (RPTPK)
    NP_001025073.2
    XP_063121937.1
    XP_063121938.1
    XP_063121941.1
    XP_063121942.1
    XP_063121945.1
    XP_063121947.1
    XP_063121950.1
    XP_063121954.1
    XP_063121957.1
    XP_063121959.1
    XP_063121968.1
    XP_063121975.1
    XP_063121976.1
    XP_063121977.1
    XP_063121983.1
    XP_063121989.1
    XP_063121997.1
    XP_063122006.1
    XP_063122009.1
    XP_063122013.1
    XP_063122014.1
    XP_063122015.1
    XP_063122018.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029902.2 → NP_001025073.2  receptor-type tyrosine-protein phosphatase kappa precursor

      See identical proteins and their annotated locations for NP_001025073.2

      Status: PROVISIONAL

      Source sequence(s)
      AB297790
      UniProtKB/TrEMBL
      A5I9F0, F1LPL4
      Conserved Domains (9) summary
      cd06263
      Location:35 → 191
      MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...
      smart00137
      Location:31 → 191
      MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
      smart00194
      Location:886 → 1140
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:201 → 287
      IG_like; Immunoglobulin like
      cd00047
      Location:913 → 1140
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:487 → 588
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam00041
      Location:293 → 371
      fn3; Fibronectin type III domain
      pfam00102
      Location:1200 → 1434
      Y_phosphatase; Protein-tyrosine phosphatase
      cl11960
      Location:203 → 283
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      18557091..19056297 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265927.1 → XP_063121997.1  receptor-type tyrosine-protein phosphatase kappa isoform X17

    2. XM_063265913.1 → XP_063121983.1  receptor-type tyrosine-protein phosphatase kappa isoform X15

    3. XM_063265905.1 → XP_063121975.1  receptor-type tyrosine-protein phosphatase kappa isoform X12

    4. XM_063265948.1 → XP_063122018.1  receptor-type tyrosine-protein phosphatase kappa isoform X23

    5. XM_063265880.1 → XP_063121950.1  receptor-type tyrosine-protein phosphatase kappa isoform X7

    6. XM_063265868.1 → XP_063121938.1  receptor-type tyrosine-protein phosphatase kappa isoform X2

    7. XM_063265919.1 → XP_063121989.1  receptor-type tyrosine-protein phosphatase kappa isoform X16

    8. XM_063265907.1 → XP_063121977.1  receptor-type tyrosine-protein phosphatase kappa isoform X14

    9. XM_063265906.1 → XP_063121976.1  receptor-type tyrosine-protein phosphatase kappa isoform X13

    10. XM_063265898.1 → XP_063121968.1  receptor-type tyrosine-protein phosphatase kappa isoform X11

      Related
      ENSRNOP00000105620.1, ENSRNOT00000150254.1

    11. XM_063265887.1 → XP_063121957.1  receptor-type tyrosine-protein phosphatase kappa isoform X9

    12. XM_063265945.1 → XP_063122015.1  receptor-type tyrosine-protein phosphatase kappa isoform X22

      Related
      ENSRNOP00000108431.1, ENSRNOT00000156515.1

    13. XM_063265877.1 → XP_063121947.1  receptor-type tyrosine-protein phosphatase kappa isoform X6

      Related
      ENSRNOP00000100835.1, ENSRNOT00000121655.1

    14. XM_063265889.1 → XP_063121959.1  receptor-type tyrosine-protein phosphatase kappa isoform X10

      Related
      ENSRNOP00000107475.1, ENSRNOT00000121569.1

    15. XM_063265884.1 → XP_063121954.1  receptor-type tyrosine-protein phosphatase kappa isoform X8

    16. XM_063265875.1 → XP_063121945.1  receptor-type tyrosine-protein phosphatase kappa isoform X5

    17. XM_063265871.1 → XP_063121941.1  receptor-type tyrosine-protein phosphatase kappa isoform X3

      Related
      ENSRNOP00000104699.1, ENSRNOT00000132092.1

    18. XM_063265872.1 → XP_063121942.1  receptor-type tyrosine-protein phosphatase kappa isoform X4

    19. XM_063265867.1 → XP_063121937.1  receptor-type tyrosine-protein phosphatase kappa isoform X1

      Related
      ENSRNOP00000099423.1, ENSRNOT00000151000.1

    20. XM_063265943.1 → XP_063122013.1  receptor-type tyrosine-protein phosphatase kappa isoform X20

    21. XM_063265939.1 → XP_063122009.1  receptor-type tyrosine-protein phosphatase kappa isoform X19

    22. XM_063265936.1 → XP_063122006.1  receptor-type tyrosine-protein phosphatase kappa isoform X18

    23. XM_063265944.1 → XP_063122014.1  receptor-type tyrosine-protein phosphatase kappa isoform X21

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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