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    Tle6 TLE family member 6, subcortical maternal complex member [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299637, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tle6provided by RGD
    Official Full Name
    TLE family member 6, subcortical maternal complex memberprovided by RGD
    Primary source
    RGD:1561530
    See related
    EnsemblRapid:ENSRNOG00000006350 AllianceGenome:RGD:1561530
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561530
    Summary
    Predicted to enable transcription corepressor activity. Predicted to be involved in several processes, including cytoskeleton organization; embryonic process involved in female pregnancy; and negative regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within positive regulation of neurogenesis and positive regulation of neuron differentiation. Predicted to be located in cell cortex. Predicted to be part of subcortical maternal complex and transcription regulator complex. Predicted to be active in nucleus. Orthologous to human TLE6 (TLE family member 6, subcortical maternal complex member). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 13.9), Kidney (RPKM 8.9) and 6 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tle6 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (8757846..8769405)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8107050..8118639)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (10964136..10988127)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551996 Neighboring gene sirtuin 6 Neighboring gene TLE family member 2, transcriptional corepressor Neighboring gene TLE family member 5, transcriptional modulator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. TLE6 mutation causes the earliest known human embryonic lethality. Alazami AM, et al. Genome Biol, 2015 Nov 5. PMID 26537248, Free PMC Article
    2. Distribution of RNA binding protein MOEP19 in the oocyte cortex and early embryo indicates pre-patterning related to blastomere polarity and trophectoderm specification. Herr JC, et al. Dev Biol, 2008 Feb 15. PMID 18191828, Free PMC Article
    3. A subcortical maternal complex essential for preimplantation mouse embryogenesis. Li L, et al. Dev Cell, 2008 Sep. PMID 18804437, Free PMC Article
    4. Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. Marçal N, et al. Mol Cell Biol, 2005 Dec. PMID 16314515, Free PMC Article
    5. Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis. Zheng P, et al. Proc Natl Acad Sci U S A, 2009 May 5. PMID 19376971, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in embryonic process involved in female pregnancy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of spindle localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrion localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatogonial cell division ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of subcortical maternal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transducin-like enhancer protein 6
    Names
    transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      8757846..8769405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080433.2 → XP_038936361.1  transducin-like enhancer protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVQ7
      Conserved Domains (2) summary
      sd00039
      Location:252 → 306
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:251 → 538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    2. XM_006241027.4 → XP_006241089.2  transducin-like enhancer protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZVQ7
      Conserved Domains (2) summary
      sd00039
      Location:252 → 306
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:251 → 538
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    3. XM_006241030.5 → XP_006241092.2  transducin-like enhancer protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVQ7
      Related
      ENSRNOP00000008360.9, ENSRNOT00000008360.10
      Conserved Domains (2) summary
      sd00039
      Location:226 → 280
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:225 → 512
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    4. XM_063264486.1 → XP_063120556.1  transducin-like enhancer protein 6 isoform X3

      Related
      ENSRNOP00000081779.1, ENSRNOT00000109747.2

    5. XM_063264487.1 → XP_063120557.1  transducin-like enhancer protein 6 isoform X3

    6. XM_017595153.3 → XP_017450642.2  transducin-like enhancer protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZVQ7
      Conserved Domains (2) summary
      sd00039
      Location:209 → 263
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:208 → 495
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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