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    ppp3cb protein phosphatase 3, catalytic subunit, beta isozyme [ Danio rerio (zebrafish) ]

    Gene ID: 550554, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ppp3cbprovided by ZNC
    Official Full Name
    protein phosphatase 3, catalytic subunit, beta isozymeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050417-406
    See related
    Ensembl:ENSDARG00000025106 AllianceGenome:ZFIN:ZDB-GENE-050417-406
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fq19c08; zgc:110141
    Summary
    Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade. Predicted to act upstream of or within calcineurin-mediated signaling. Predicted to be part of calcineurin complex. Predicted to be active in cytosol. Is expressed in hatching gland; integument; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See ppp3cb in Genome Data Viewer
    Location:
    chromosome: 14
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (7789093..7891682, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (7482684..7585328, complement)

    Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene si:ch211-39i2.2 Neighboring gene stimulator of interferon response cGAMP interactor 1 Neighboring gene ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) Neighboring gene zgc:110843

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cabin1 expression suggests roles in neuronal development. Hammond DR, et al. Dev Dyn, 2010 Sep. PMID 20652955
    2. Therapeutic potential of N-acetylcysteine in acrylamide acute neurotoxicity in adult zebrafish. Faria M, et al. Sci Rep, 2019 Nov 11. PMID 31712630, Free PMC Article
    3. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calmodulin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-dependent protein phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcineurin-NFAT signaling cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within calcineurin-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of calcineurin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
    NP_001017856.1
    XP_009305997.1
    XP_009305999.1
    XP_021336694.1
    XP_068069308.1
    XP_068069309.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017856.1 → NP_001017856.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

      See identical proteins and their annotated locations for NP_001017856.1

      Status: PROVISIONAL

      Source sequence(s)
      BC092753
      UniProtKB/TrEMBL
      Q568R4
      Related
      ENSDARP00000032726.7, ENSDART00000029981.8
      Conserved Domains (2) summary
      smart00156
      Location:49 → 318
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:30 → 334
      MPP_PP2B; PP2B, metallophosphatase domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007125.7 Reference GRCz11 Primary Assembly

      Range
      7789093..7891682 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068213208.1 → XP_068069309.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

    2. XM_021481019.2 → XP_021336694.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

      UniProtKB/TrEMBL
      A0A8M9QGE2
      Conserved Domains (1) summary
      cd07416
      Location:29 → 333
      MPP_PP2B; PP2B, metallophosphatase domain

    3. XM_009307724.4 → XP_009305999.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

      UniProtKB/TrEMBL
      A0A8M3AZJ8
      Conserved Domains (2) summary
      smart00156
      Location:60 → 329
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:41 → 345
      MPP_PP2B; PP2B, metallophosphatase domain

    4. XM_009307722.4 → XP_009305997.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

      UniProtKB/TrEMBL
      A0A8M3BEY4
      Conserved Domains (2) summary
      smart00156
      Location:60 → 329
      PP2Ac; Protein phosphatase 2A homologues, catalytic domain
      cd07416
      Location:41 → 345
      MPP_PP2B; PP2B, metallophosphatase domain

    5. XM_068213207.1 → XP_068069308.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version

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