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    klhl17 kelch-like family member 17 [ Danio rerio (zebrafish) ]

    Gene ID: 336187, updated on 28-Oct-2024

    Summary

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    Official Symbol
    klhl17provided by ZNC
    Official Full Name
    kelch-like family member 17provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-8131
    See related
    Ensembl:ENSDARG00000037324 AllianceGenome:ZFIN:ZDB-GENE-030131-8131
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj54g09; si:dkey-98j1.3
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in telencephalon. Orthologous to human KLHL17 (kelch like family member 17). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See klhl17 in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (23182047..23214599)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (23255486..23288048)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene sterile alpha motif domain containing 11 Neighboring gene NOC2-like nucleolar associated transcriptional repressor Neighboring gene pleckstrin homology domain containing, family N member 1 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. foxl2 and foxl3 are two ancient paralogs that remain fully functional in teleosts. Crespo B, et al. Gen Comp Endocrinol, 2013 Dec 1. PMID 24045113
    2. Saltatory evolution of the ectodermal neural cortex gene family at the vertebrate origin. Feiner N, et al. Genome Biol Evol, 2013. PMID 23843192, Free PMC Article
    3. Genome-wide, whole mount in situ analysis of transcriptional regulators in zebrafish embryos. Armant O, et al. Dev Biol, 2013 Aug 15. PMID 23684812, Free PMC Article
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 17
    Names
    kelch-like 17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      23182047..23214599
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003201200.6 → XP_003201248.1  kelch-like protein 17

      See identical proteins and their annotated locations for XP_003201248.1

      UniProtKB/TrEMBL
      A0A8M2B929, E7FB30
      Related
      ENSDARP00000119330.1, ENSDART00000137353.3
      Conserved Domains (4) summary
      smart00612
      Location:528 → 572
      Kelch; Kelch domain
      PHA03098
      Location:41 → 507
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:375 → 418
      Kelch; KELCH repeat [structural motif]
      cd18246
      Location:2 → 140
      BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

    2. XM_005162205.5 → XP_005162262.1  kelch-like protein 17

      See identical proteins and their annotated locations for XP_005162262.1

      UniProtKB/TrEMBL
      A0A8M2B929, E7FB30
      Related
      ENSDARP00000156064.1, ENSDART00000184920.1
      Conserved Domains (4) summary
      smart00612
      Location:528 → 572
      Kelch; Kelch domain
      PHA03098
      Location:41 → 507
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:375 → 418
      Kelch; KELCH repeat [structural motif]
      cd18246
      Location:2 → 140
      BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395148.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      104471..137023
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021473681.2 → XP_021329356.1  kelch-like protein 17

      UniProtKB/TrEMBL
      A0A8M2B929, E7FB30
      Conserved Domains (4) summary
      smart00612
      Location:528 → 572
      Kelch; Kelch domain
      PHA03098
      Location:41 → 507
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:375 → 418
      Kelch; KELCH repeat [structural motif]
      cd18246
      Location:2 → 140
      BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)

    2. XM_021473682.2 → XP_021329357.1  kelch-like protein 17

      UniProtKB/TrEMBL
      A0A8M2B929, E7FB30
      Conserved Domains (4) summary
      smart00612
      Location:528 → 572
      Kelch; Kelch domain
      PHA03098
      Location:41 → 507
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:375 → 418
      Kelch; KELCH repeat [structural motif]
      cd18246
      Location:2 → 140
      BTB_POZ_KLHL17_actinfilin; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17)
    Nucleotide Protein Strain
    Heading Accession and Version

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