Baiap3 BAI1-associated protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Baiap3provided by MGI
Official Full Name: BAI1-associated protein 3provided by MGI
Primary source: MGI:MGI:2685783
See related: Ensembl:ENSMUSG00000047507 AllianceGenome:MGI:2685783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bap3; Gm937
Summary: Predicted to enable calcium ion binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in regulation of GABAergic synaptic transmission and regulation of behavior. Is active in GABA-ergic synapse. Is expressed in brain. Orthologous to human BAIAP3 (BAI1 associated protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 8.6), CNS E18 (RPKM 8.4) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 12.53 cM

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (25461633..25475255, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (25242659..25256364, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Baiap3 is gender specifically associated with anxiety and benzodiazepine use disorder.
Title: Genetic markers of a Munc13 protein family member, BAIAP3, are gender specifically associated with anxiety and benzodiazepine abuse in mice and humans.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	ISO Inferred from Sequence Orthology more info
enables SNARE binding	ISS Inferred from Sequence or Structural Similarity more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	ISS Inferred from Sequence or Structural Similarity more info
enables syntaxin binding	IEA Inferred from Electronic Annotation more info
enables syntaxin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in dense core granule maturation	IEA Inferred from Electronic Annotation more info
involved_in dense core granule maturation	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neurotransmitter secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neurotransmitter secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dense core granule exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dense core granule exocytosis	IEA Inferred from Electronic Annotation more info
involved_in regulation of dense core granule exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, GABAergic	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in late endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome membrane	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in secretory vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in trans-Golgi network membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in trans-Golgi network membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: BAI1-associated protein 3

Names: brain-specific angiogenesis inhibitor I-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163270.2 → NP_001156742.1 BAI1-associated protein 3

See identical proteins and their annotated locations for NP_001156742.1

Status: VALIDATED

Source sequence(s)

AC122454

Consensus CDS

CCDS50033.1

UniProtKB/Swiss-Prot

E9QQ76, Q6RUT4, Q80TT2, S4R1E7

UniProtKB/TrEMBL

B2RY68

Related

ENSMUSP00000138188.2, ENSMUST00000182056.8

Conserved Domains (3) summary

cd04009
Location:973 → 1102

C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins

cd08676
Location:131 → 330

C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins

pfam10540
Location:852 → 954

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain
NM_001408206.1 → NP_001395135.1 BAI1-associated protein 3

Status: VALIDATED

Source sequence(s)

AC122454

UniProtKB/Swiss-Prot

E9QQ76, Q6RUT4, Q80TT2, S4R1E7

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

25461633..25475255 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524643.5 → XP_006524706.1 BAI1-associated protein 3 isoform X1

See identical proteins and their annotated locations for XP_006524706.1

UniProtKB/Swiss-Prot

E9QQ76, Q6RUT4, Q80TT2, S4R1E7

UniProtKB/TrEMBL

B2RY68

Conserved Domains (3) summary

cd04009
Location:973 → 1102

C2B_Munc13-like; C2 domain second repeat in Munc13 (mammalian uncoordinated)-like proteins

cd08676
Location:131 → 330

C2A_Munc13-like; C2 domain first repeat in Munc13 (mammalian uncoordinated)-like proteins

pfam10540
Location:852 → 954

Membr_traf_MHD; Munc13 (mammalian uncoordinated) homology domain