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    CCNJ cyclin J [ Homo sapiens (human) ]

    Gene ID: 54619, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CCNJprovided by HGNC
    Official Full Name
    cyclin Jprovided by HGNC
    Primary source
    HGNC:HGNC:23434
    See related
    Ensembl:ENSG00000107443 MIM:620395; AllianceGenome:HGNC:23434
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    bA690P14.1
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in mitotic cell cycle phase transition. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in centrosome; cytoplasm; and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 3.4), testis (RPKM 2.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See CCNJ in Genome Data Viewer
    Location:
    10q24.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (96043068..96060870)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (96922365..96940179)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (97803340..97820627)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:97454143-97454644 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 1 Neighboring gene MPRA-validated peak1056 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3804 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2650 Neighboring gene ENTPD1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3805 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3807 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3808 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3809 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3811 Neighboring gene Sharpr-MPRA regulatory region 13404 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97645298-97645457 Neighboring gene MPRA-validated peak1059 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3813 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3814 Neighboring gene coiled-coil and C2 domain containing 2B Neighboring gene ribosomal protein L21 pseudogene 90 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:97786197-97787396 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:97802729-97802923 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2652 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3816 Neighboring gene microRNA 3157 Neighboring gene RNA, U6 small nuclear 271, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma. Takano N, et al. Int J Oncol, 2015 May. PMID 25672416
    2. Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J. Shi L, et al. BMC Cancer, 2017 Feb 15. PMID 28202053, Free PMC Article
    3. Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer. Sun X, et al. Cell Death Dis, 2015 Oct 15. PMID 26469956, Free PMC Article
    4. MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1. Venturutti L, et al. Oncogene, 2016 Dec 1. PMID 27157613, Free PMC Article
    5. miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9. Feliciano A, et al. PLoS One, 2013. PMID 24098452, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High Cyclin J expression is associated with drug resistance in non-small cell lung cancer.
      Title: Up-regulation of miR-146a increases the sensitivity of non-small cell lung cancer to DDP by downregulating cyclin J.
    2. we identified cyclin J and far upstream element-binding protein 1 (FUBP1) as novel miR-16 targets, which mediate miR-16 antiproliferative effects.
      Title: MiR-16 mediates trastuzumab and lapatinib response in ErbB-2-positive breast and gastric cancer via its novel targets CCNJ and FUBP1.
    3. CCNJ is a target of miR205 mediated downregulation in bladder cancer cells.
      Title: Long non-coding RNA HOTAIR regulates cyclin J via inhibition of microRNA-205 expression in bladder cancer.
    4. In conclusion, our results indicated that CCNJ could be a novel prognostic marker of HCC, and this study indicated that triple combination array analysis was effective in detecting new tumor-related genes and their mechanisms.
      Title: CCNJ detected by triple combination array analysis as a tumor-related gene of hepatocellular carcinoma.
    5. miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-alpha, CCNJ, and MEGF9.
      Title: miR-125b acts as a tumor suppressor in breast tumorigenesis via its novel direct targets ENPEP, CK2-α, CCNJ, and MEGF9.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-J

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134375.2 → NP_001127847.1  cyclin-J isoform 1

      See identical proteins and their annotated locations for NP_001127847.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK001757, AK025932, BC043175, BM789816
      Consensus CDS
      CCDS44462.1
      UniProtKB/TrEMBL
      B3KRX5
      Related
      ENSP00000435373.2, ENST00000465148.3
      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 251
      Cyclin_C; Cyclin, C-terminal domain

    2. NM_001134376.2 → NP_001127848.1  cyclin-J isoform 3

      See identical proteins and their annotated locations for NP_001127848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 3) that lacks twelve internal amino acids, when compared to isoform 1.
      Source sequence(s)
      AK001757, AK025932, BC043175
      Consensus CDS
      CCDS44463.1
      UniProtKB/TrEMBL
      B3KRX5
      Related
      ENSP00000384498.2, ENST00000403870.7
      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 239
      Cyclin_C; Cyclin, C-terminal domain

    3. NM_019084.5 → NP_061957.2  cyclin-J isoform 2

      See identical proteins and their annotated locations for NP_061957.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 2) that lacks eleven internal amino acids, when compared to isoform 1.
      Source sequence(s)
      AK001757, AK025932, BC043175
      Consensus CDS
      CCDS7445.1
      UniProtKB/Swiss-Prot
      B7Z4E7, Q5T5M9, Q86XL1, Q9NV69
      UniProtKB/TrEMBL
      B3KRX5
      Related
      ENSP00000265992.5, ENST00000265992.9
      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 240
      Cyclin_C; Cyclin, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      96043068..96060870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011539885.3 → XP_011538187.1  cyclin-J isoform X4

      See identical proteins and their annotated locations for XP_011538187.1

      UniProtKB/TrEMBL
      B3KRX5
      Conserved Domains (2) summary
      pfam00134
      Location:15 → 109
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:145 → 251
      Cyclin_C; Cyclin, C-terminal domain

    2. XM_017016354.2 → XP_016871843.1  cyclin-J isoform X1

      UniProtKB/TrEMBL
      B3KRX5
      Conserved Domains (1) summary
      cl40454
      Location:58 → 332
      CYCLIN_SF; Cyclin box fold superfamily

    3. XM_017016356.2 → XP_016871845.1  cyclin-J isoform X3

      UniProtKB/TrEMBL
      B3KRX5

    4. XM_017016355.2 → XP_016871844.2  cyclin-J isoform X2

      UniProtKB/Swiss-Prot
      B7Z4E7, Q5T5M9, Q86XL1, Q9NV69

    5. XM_005269921.4 → XP_005269978.1  cyclin-J isoform X5

      Conserved Domains (1) summary
      pfam02984
      Location:31 → 137
      Cyclin_C; Cyclin, C-terminal domain

    6. XM_047425381.1 → XP_047281337.1  cyclin-J isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      96922365..96940179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366144.1 → XP_054222119.1  cyclin-J isoform X4

    2. XM_054366141.1 → XP_054222116.1  cyclin-J isoform X1

    3. XM_054366142.1 → XP_054222117.1  cyclin-J isoform X7

    4. XM_054366143.1 → XP_054222118.1  cyclin-J isoform X3

    5. XM_054366145.1 → XP_054222120.1  cyclin-J isoform X5

    6. XM_054366146.1 → XP_054222121.1  cyclin-J isoform X6

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T5M9.2 GenPept UniProtKB/Swiss-Prot:Q5T5M9

    Gene LinkOut

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