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    Tmem161b transmembrane protein 161B [ Mus musculus (house mouse) ]

    Gene ID: 72745, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tmem161bprovided by MGI
    Official Full Name
    transmembrane protein 161Bprovided by MGI
    Primary source
    MGI:MGI:1919995
    See related
    Ensembl:ENSMUSG00000035762 AllianceGenome:MGI:1919995
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810446P07Rik
    Summary
    Involved in regulation of cardiac muscle cell action potential and regulation of heart rate. Predicted to be located in plasma membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TMEM161B (transmembrane protein 161B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 10.9), CNS E14 (RPKM 6.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem161b in Genome Data Viewer
    Location:
    13 C3; 13 44.2 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (84370415..84444085)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (84222296..84295966)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr13:84325541-84325841 Neighboring gene RIKEN cDNA A230107N01 gene Neighboring gene STARR-positive B cell enhancer ABC_E7261 Neighboring gene predicted gene 8456 Neighboring gene STARR-seq mESC enhancer starr_35162 Neighboring gene predicted gene, 46432 Neighboring gene STARR-seq mESC enhancer starr_35164 Neighboring gene STARR-seq mESC enhancer starr_35165 Neighboring gene predicted gene, 41011 Neighboring gene STARR-seq mESC enhancer starr_35166 Neighboring gene STARR-seq mESC enhancer starr_35167 Neighboring gene STARR-seq mESC enhancer starr_35168 Neighboring gene predicted gene, 34196 Neighboring gene predicted gene, 34246

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart. Smith KA, et al. Mamm Genome, 2023 Jun. PMID 37222785, Free PMC Article
    2. TMEM161B modulates radial glial scaffolding in neocortical development. Wang L, et al. Proc Natl Acad Sci U S A, 2023 Jan 24. PMID 36669109, Free PMC Article
    3. TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system. Akula SK, et al. Proc Natl Acad Sci U S A, 2023 Jan 24. PMID 36669111, Free PMC Article
    4. The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm. Koopman CD, et al. Proc Natl Acad Sci U S A, 2021 Mar 2. PMID 33597309, Free PMC Article
    5. Disruption of Visc-2, a Brain-Expressed Conserved Long Noncoding RNA, Does Not Elicit an Overt Anatomical or Behavioral Phenotype. Oliver PL, et al. Cereb Cortex, 2015 Oct. PMID 25209608, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart.
      Title: Fins, fur, and wings: the study of Tmem161b across species, and what it tells us about its function in the heart.
    2. TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
      Title: TMEM161B regulates cerebral cortical gyration, Sonic Hedgehog signaling, and ciliary structure in the developing central nervous system.
    3. TMEM161B modulates radial glial scaffolding in neocortical development.
      Title: TMEM161B modulates radial glial scaffolding in neocortical development.
    4. The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.
      Title: The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Gene trapped (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cardiac muscle cell action potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of heart rate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 161B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001361908.1 → NP_001348837.1  transmembrane protein 161B isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC154335, CT033785
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 357
      Tmemb_161AB; Predicted transmembrane protein 161AB

    2. NM_001361909.1 → NP_001348838.1  transmembrane protein 161B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 2 and 5 both encode the same isoform (c).
      Source sequence(s)
      AC154335, CT033785
      Consensus CDS
      CCDS88497.1
      UniProtKB/TrEMBL
      A0A286YCA7
      Related
      ENSMUSP00000152891.2, ENSMUST00000225069.2
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 303
      Tmemb_161AB; Predicted transmembrane protein 161AB

    3. NM_001361911.1 → NP_001348840.1  transmembrane protein 161B isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 2 and 5 both encode the same isoform (c).
      Source sequence(s)
      AC154335, CT033785
      Consensus CDS
      CCDS88497.1
      UniProtKB/TrEMBL
      A0A286YCA7
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 303
      Tmemb_161AB; Predicted transmembrane protein 161AB

    4. NM_175187.5 → NP_780396.2  transmembrane protein 161B isoform a

      See identical proteins and their annotated locations for NP_780396.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      BC051663, BM899262, BY239899
      Consensus CDS
      CCDS36739.1
      UniProtKB/Swiss-Prot
      Q8BT72, Q8C2L6
      Related
      ENSMUSP00000055208.8, ENSMUST00000057495.10
      Conserved Domains (1) summary
      pfam10268
      Location:2 → 484
      Tmemb_161AB; Predicted transmembrane protein 161AB

    RNA

    1. NR_029419.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, compared to variant 1, which result in a frameshift and early stop codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated and the transcript is a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK013305, BC060067, BM899262, BY239899
      Related
      ENSMUST00000223827.2

    2. NR_155262.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC154335, CT033785

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      84370415..84444085
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158188.1 → XP_036014081.1  transmembrane protein 161B isoform X1

      UniProtKB/TrEMBL
      A0A286YCA7
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 303
      Tmemb_161AB; Predicted transmembrane protein 161AB

    2. XM_030247423.2 → XP_030103283.1  transmembrane protein 161B isoform X1

      UniProtKB/TrEMBL
      A0A286YCA7
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 303
      Tmemb_161AB; Predicted transmembrane protein 161AB

    3. XM_006517405.4 → XP_006517468.1  transmembrane protein 161B isoform X1

      See identical proteins and their annotated locations for XP_006517468.1

      UniProtKB/TrEMBL
      A0A286YCA7
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 303
      Tmemb_161AB; Predicted transmembrane protein 161AB

    4. XM_006517404.4 → XP_006517467.1  transmembrane protein 161B isoform X1

      See identical proteins and their annotated locations for XP_006517467.1

      UniProtKB/TrEMBL
      A0A286YCA7
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 303
      Tmemb_161AB; Predicted transmembrane protein 161AB

    5. XM_011244565.4 → XP_011242867.1  transmembrane protein 161B isoform X1

      See identical proteins and their annotated locations for XP_011242867.1

      UniProtKB/TrEMBL
      A0A286YCA7
      Conserved Domains (1) summary
      pfam10268
      Location:1 → 303
      Tmemb_161AB; Predicted transmembrane protein 161AB
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C2L6.1 GenPept UniProtKB/Swiss-Prot:Q8C2L6

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