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    Kat6b K(lysine) acetyltransferase 6B [ Mus musculus (house mouse) ]

    Gene ID: 54169, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kat6bprovided by MGI
    Official Full Name
    K(lysine) acetyltransferase 6Bprovided by MGI
    Primary source
    MGI:MGI:1858746
    See related
    Ensembl:ENSMUSG00000021767 AllianceGenome:MGI:1858746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    qkf; Morf; Myst4; MYST-4; querkopf; mKIAA0383; B130044K16Rik
    Summary
    Enables histone acetyltransferase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in chromatin. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; facial prominence; genitourinary system; and limb mesenchyme. Used to study Noonan syndrome. Human ortholog(s) of this gene implicated in Ohdo syndrome, SBBYS variant; bipolar disorder; breast cancer; and leiomyoma. Orthologous to human KAT6B (lysine acetyltransferase 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 5.4), frontal lobe adult (RPKM 5.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kat6b in Genome Data Viewer
    Location:
    14 A3; 14 11.73 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (21549284..21722546)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (21499216..21672478)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36127 Neighboring gene adenosine kinase Neighboring gene VISTA enhancer mm1738 Neighboring gene STARR-seq mESC enhancer starr_36134 Neighboring gene predicted gene, 30363 Neighboring gene STARR-positive B cell enhancer ABC_E8945 Neighboring gene STARR-positive B cell enhancer ABC_E605 Neighboring gene STARR-positive B cell enhancer ABC_E4100 Neighboring gene STARR-seq mESC enhancer starr_36143 Neighboring gene STARR-seq mESC enhancer starr_36148 Neighboring gene VISTA enhancer mm1600 Neighboring gene dual specificity phosphatase 29 Neighboring gene dual specificity phosphatase 13B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The transcriptional coactivator Querkopf controls adult neurogenesis. Merson TD, et al. J Neurosci, 2006 Nov 1. PMID 17079664, Free PMC Article
    2. The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function. Bergamasco MI, et al. Stem Cell Reports, 2024 Apr 9. PMID 38518784, Free PMC Article
    3. Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation. Khokhar ES, et al. Exp Hematol, 2020 Feb. PMID 32014431, Free PMC Article
    4. Querkopf, a histone acetyltransferase, is essential for embryonic neurogenesis. Thomas T, et al. Front Biosci, 2004 Jan 1. PMID 14766340
    5. [KAT6B promotes LPS-triggered IL-6 production via enhancing recruitment of H3K23 acetylation to IL-6 promoter region]. Sun D, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2017 Nov. PMID 29268844

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function.
      Title: The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function.
    2. SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic mimicry in glioblastoma cells.
      Title: SNORD17-mediated KAT6B mRNA 2'-O-methylation regulates vasculogenic mimicry in glioblastoma cells.
    3. work identifies KAT6B as a novel epigenetic regulator of hematopoietic differentiation and a target to improve aged immune function.
      Title: Aging-associated decrease in the histone acetyltransferase KAT6B is linked to altered hematopoietic stem cell differentiation.
    4. Fluorescence correlation spectroscopy analyses suggest a more compact chromatin organization in K6b-/- cells and impaired interactions of Oct4 and Nanog with chromatin.
      Title: Kat6b Modulates Oct4 and Nanog Binding to Chromatin in Embryonic Stem Cells and Is Required for Efficient Neural Differentiation.
    5. Silence of lysine acetyltransferase 6B (KAT6B) suppressed lipopolysaccharide(LPS)-induced IL-6 production in peritoneal macrophages.
      Title: [KAT6B promotes LPS-triggered IL-6 production via enhancing recruitment of H3K23 acetylation to IL-6 promoter region].
    6. Data indicate that Myst4, Jmjd2b, Aof1 genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.
      Title: Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells.
    7. Data show that H3 acetylation by Myst4 is important for neural, craniofacial, and skeletal morphogenesis, mainly through its ability to specifically regulating the MAPK signaling pathway.
      Title: Disruption of the histone acetyltransferase MYST4 leads to a Noonan syndrome-like phenotype and hyperactivated MAPK signaling in humans and mice.
    8. Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
      Title: Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase and deacetylase activities in murine skin and tumors.
    9. MORF4 has a role in cellular aging, and MRG15 associates with both histone deacetylases and histone acetyl transferase complexes [review]
      Title: The role of the MORF/MRG family of genes in cell growth, differentiation, DNA repair, and thereby aging.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K14 acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptide-lysine-N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of developmental process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of hemopoiesis NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MOZ/MORF histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of MOZ/MORF histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    histone acetyltransferase KAT6B
    Names
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    MYST histone acetyltransferase monocytic leukemia 4
    histone acetyltransferase MYST4
    histone acetyltransferase querkopf
    monocytic leukemia
    protein querkopf
    NP_001192170.1
    NP_001395624.1
    NP_001395625.1
    NP_059507.2
    XP_006519326.1
    XP_006519327.1
    XP_006519328.1
    XP_006519332.1
    XP_017171571.1
    XP_017171573.1
    XP_030103747.1
    XP_030103748.1
    XP_036014649.1
    XP_036014650.1
    XP_036014651.1
    XP_036014652.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001205241.2 → NP_001192170.1  histone acetyltransferase KAT6B isoform 1

      See identical proteins and their annotated locations for NP_001192170.1

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978
      Consensus CDS
      CCDS59615.1
      UniProtKB/TrEMBL
      Q3UH94
      Related
      ENSMUSP00000138511.2, ENSMUST00000182855.8
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430 → 698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213 → 271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

    2. NM_001408695.1 → NP_001395624.1  histone acetyltransferase KAT6B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978

    3. NM_001408696.1 → NP_001395625.1  histone acetyltransferase KAT6B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978
      UniProtKB/Swiss-Prot
      E9QK86, Q7TNW5, Q8BG35, Q8BRB7, Q8C441, Q9JKX5
      Related
      ENSMUSP00000138421.2, ENSMUST00000182964.3

    4. NM_017479.4 → NP_059507.2  histone acetyltransferase KAT6B isoform 1

      See identical proteins and their annotated locations for NP_059507.2

      Status: VALIDATED

      Source sequence(s)
      AC115122, AC148978
      Consensus CDS
      CCDS59615.1
      UniProtKB/TrEMBL
      Q3UH94
      Related
      ENSMUSP00000138377.2, ENSMUST00000182405.9
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430 → 698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213 → 271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      21549284..21722546
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519265.5 → XP_006519328.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519328.1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    2. XM_036158758.1 → XP_036014651.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:430 → 698
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213 → 271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

    3. XM_006519264.5 → XP_006519327.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519327.1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    4. XM_036158756.1 → XP_036014649.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Related
      ENSMUSP00000159058.2, ENSMUST00000238837.2
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    5. XM_036158759.1 → XP_036014652.1  histone acetyltransferase KAT6B isoform X7

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:367 → 635
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213 → 271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

    6. XM_030247887.2 → XP_030103747.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    7. XM_017316082.3 → XP_017171571.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    8. XM_006519263.5 → XP_006519326.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_006519326.1

      UniProtKB/TrEMBL
      A0A5F8MQ39, Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721 → 989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    9. XM_036158757.1 → XP_036014650.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:584 → 852
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 318
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:213 → 270
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    10. XM_017316084.3 → XP_017171573.1  histone acetyltransferase KAT6B isoform X7

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (4) summary
      smart00526
      Location:94 → 168
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:367 → 635
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:272 → 310
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:213 → 271
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)

    11. XM_006519269.5 → XP_006519332.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      Q3UH94
      Conserved Domains (2) summary
      PLN00104
      Location:436 → 704
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:1 → 33
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)

    12. XM_030247888.2 → XP_030103748.1  histone acetyltransferase KAT6B isoform X8

      Conserved Domains (1) summary
      PLN00104
      Location:5 → 57
      PLN00104; MYST -like histone acetyltransferase; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BRB7.3 GenPept UniProtKB/Swiss-Prot:Q8BRB7

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