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    Nnat neuronatin [ Mus musculus (house mouse) ]

    Gene ID: 18111, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Nnatprovided by MGI
    Official Full Name
    neuronatinprovided by MGI
    Primary source
    MGI:MGI:104716
    See related
    Ensembl:ENSMUSG00000067786 AllianceGenome:MGI:104716
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Peg5; 5730414I02Rik
    Summary
    Acts upstream of or within positive regulation of insulin secretion and response to glucose. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human NNAT (neuronatin). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in whole brain E14.5 (RPKM 921.6), CNS E14 (RPKM 733.0) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nnat in Genome Data Viewer
    Location:
    2 78.4 cM; 2 H1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (157401936..157404445)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (157560078..157562525)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rous sarcoma oncogene Neighboring gene VISTA enhancer mm1673 Neighboring gene predicted gene 14279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:157392020-157392207 Neighboring gene bladder cancer associated protein Neighboring gene STARR-seq mESC enhancer starr_06215 Neighboring gene pluripotency associated transcript 27 Neighboring gene STARR-seq mESC enhancer starr_06217 Neighboring gene predicted gene, 34293

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells. Joe MK, et al. Cell Signal, 2008 May. PMID 18289831
    2. Neuronatin Is Associated with an Anti-Inflammatory Role in the White Adipose Tissue. Ka HI, et al. J Microbiol Biotechnol, 2017 Jun 28. PMID 28335587
    3. Temporal and spatial expression pattern of Nnat during mouse eye development. Sel S, et al. Gene Expr Patterns, 2017 Jan. PMID 28038958
    4. Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice. Scott WR, et al. PLoS One, 2013. PMID 23527188, Free PMC Article
    5. Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice. Millership SJ, et al. Mol Metab, 2018 Dec. PMID 30279096, Free PMC Article

    See all (78) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.
      Title: DNA methylation-mediated silencing of Neuronatin promotes hepatocellular carcinoma proliferation through the PI3K-Akt signaling pathway.
    2. Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.
      Title: Bisphenol A induces miR-708-5p through an ER stress-mediated mechanism altering neuronatin and neuropeptide Y expression in hypothalamic neuronal models.
    3. Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
      Title: Neuronatin promotes SERCA uncoupling and its expression is altered in skeletal muscles of high-fat diet-fed mice.
    4. Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
      Title: Murine neuronatin deficiency is associated with a hypervariable food intake and bimodal obesity.
    5. Nnat deletion was associated with postnatal growth restriction and adult obesity.
      Title: Neuronatin deletion causes postnatal growth restriction and adult obesity in 129S2/Sv mice.
    6. investigation of the function of Nnat in the adipose tissue; results indicate that NNAT plays an anti-inflammatory role in the adipose tissue
      Title: Neuronatin Is Associated with an Anti-Inflammatory Role in the White Adipose Tissue.
    7. The expression pattern suggests that Nnat may play an important role during eye development and in the maintenance of mature eye.
      Title: Temporal and spatial expression pattern of Nnat during mouse eye development.
    8. Nnat expression in hypothalamus is regulated by short-term nutrient availability, but unaltered by diet-induced obesity or calorie restriction.
      Title: Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.
    9. Neuronatin appears to be a novel regulator of browning and metabolic substrate disposal in white adipocytes.
      Title: Loss of neuronatin promotes "browning" of primary mouse adipocytes while reducing Glut1-mediated glucose disposal.
    10. the Neuronatin locus employs the most basic mechanism for establishing allele-specific gene expression
      Title: An intronic DNA sequence within the mouse Neuronatin gene exhibits biochemical characteristics of an ICR and acts as a transcriptional activator in Drosophila.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of insulin secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neuronatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291128.1 → NP_001278057.1  neuronatin isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (c).
      Source sequence(s)
      AK160626, AL672259, BQ030646, BU705167, DN176829
      Consensus CDS
      CCDS71174.1
      UniProtKB/TrEMBL
      G3X9K1
      Related
      ENSMUSP00000085836.6, ENSMUST00000088484.6

    2. NM_001291129.1 → NP_001278058.1  neuronatin isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an alternate exon but contains a different in-frame exon in the central coding region, compared to variant 3. The encoded isoform (d) is shorter than isoform c.
      Source sequence(s)
      AK160626, AL672259, BQ030646, BU705167, DV062509
      Consensus CDS
      CCDS71175.1
      UniProtKB/TrEMBL
      G3UWR7
      Related
      ENSMUSP00000133397.2, ENSMUST00000173595.2

    3. NM_001291130.1 → NP_001278059.1  neuronatin isoform e

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (e) has a distinct C-terminus and is shorter than isoform c.
      Source sequence(s)
      AK160626, AL672259, BQ030646, BU705167
      Consensus CDS
      CCDS79857.1
      UniProtKB/TrEMBL
      G3UWR4
      Related
      ENSMUSP00000133394.2, ENSMUST00000173839.2

    4. NM_010923.3 → NP_035053.1  neuronatin isoform alpha

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate exon but contains a different exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (alpha, also known as Neuronatin-3) has a distinct C-terminus and is shorter than isoform c.
      Source sequence(s)
      AK160626, AL672259, BQ030646, BU705167
      Consensus CDS
      CCDS38306.1
      UniProtKB/Swiss-Prot
      Q548Q0, Q61979, Q61980, Q61981
      Related
      ENSMUSP00000105152.2, ENSMUST00000109526.2

    5. NM_180960.3 → NP_851291.1  neuronatin isoform beta

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon that results in a frameshift in the 3' coding region, compared to variant 3. The encoded isoform (beta, also known as Neuronatin-2) has a distinct C-terminus and is shorter than isoform c.
      Source sequence(s)
      AK160626, AL672259, AU079843, BQ030646, BU705167
      Consensus CDS
      CCDS38307.1
      UniProtKB/TrEMBL
      Q548P9
      Related
      ENSMUSP00000129821.2, ENSMUST00000153739.9

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      157401936..157404445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159369.1 → XP_036015262.1  neuronatin isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61979.2 GenPept UniProtKB/Swiss-Prot:Q61979

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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