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    Sult2a4 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4 [ Mus musculus (house mouse) ]

    Gene ID: 434121, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Sult2a4provided by MGI
    Official Full Name
    sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 4provided by MGI
    Primary source
    MGI:MGI:3645854
    See related
    Ensembl:ENSMUSG00000074377 AllianceGenome:MGI:3645854
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm5584; EG434121
    Summary
    Predicted to enable 3'-phosphoadenosine 5'-phosphosulfate binding activity and sulfotransferase activity. Predicted to be involved in several processes, including 3'-phosphoadenosine 5'-phosphosulfate metabolic process; ethanol catabolic process; and sulfation. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Sult2a4 in Genome Data Viewer
    Location:
    7 A1; 7 8.06 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (13643602..13723516, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13909677..13989591, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 167, pseudogene 2 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_18087 Neighboring gene STARR-seq mESC enhancer starr_18088 Neighboring gene zinc finger, BED type containing 4, pseudogene 3 Neighboring gene transmembrane protein 167, pseudogene 3 Neighboring gene STARR-seq mESC enhancer starr_18089 Neighboring gene STARR-seq mESC enhancer starr_18090 Neighboring gene STARR-seq mESC enhancer starr_18091 Neighboring gene sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 3 Neighboring gene STARR-seq mESC enhancer starr_18094 Neighboring gene STARR-seq mESC enhancer starr_18095 Neighboring gene STARR-seq mESC enhancer starr_18096 Neighboring gene STARR-seq mESC enhancer starr_18097

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Age- and sex-dependent expression of multiple murine hepatic hydroxysteroid sulfotransferase (SULT2A) genes. Kocarek TA, et al. Biochem Pharmacol, 2008 Oct 15. PMID 18725207, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3'-phosphoadenosine 5'-phosphosulfate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables bile-salt sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sulfotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ethanol catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sulfation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in xenobiotic metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    sulfotransferase family member-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101534.1 → NP_001095004.1  sulfotransferase family member-like

      See identical proteins and their annotated locations for NP_001095004.1

      Status: VALIDATED

      Source sequence(s)
      AC123600, AC125016
      Consensus CDS
      CCDS52032.1
      UniProtKB/TrEMBL
      D3Z6M7, D3Z6M8, G3UWB5, L7N245
      Related
      ENSMUSP00000130490.2, ENSMUST00000165167.8
      Conserved Domains (1) summary
      pfam00685
      Location:33 → 277
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      13643602..13723516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006540163.1 → XP_006540226.1  sulfotransferase family member-like isoform X1

      Conserved Domains (1) summary
      pfam00685
      Location:34 → 187
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version

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