Kif21b kinesin family member 21B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kif21bprovided by MGI
Official Full Name: kinesin family member 21Bprovided by MGI
Primary source: MGI:MGI:109234
See related: Ensembl:ENSMUSG00000041642 AllianceGenome:MGI:109234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0449; 2610511N21Rik
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in regulation of postsynaptic membrane neurotransmitter receptor levels and retrograde dendritic transport. Acts upstream of or within corpus callosum development. Is active in glutamatergic synapse and postsynaptic endosome. Is expressed in central nervous system; dorsal root ganglion; and neural retina. Orthologous to human KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 74.1), whole brain E14.5 (RPKM 48.8) and 15 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 59.61 cM

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (136059128..136105739)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (136131390..136178001)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton.
Title: The kinesin Kif21b regulates radial migration of cortical projection neurons through a non-canonical function on actin cytoskeleton.
KIF21B-mediated Rac1 inactivation is a key molecular event in NMDAR-dependent long-term depression expression underlying cognitive flexibility in fear extinction.
Title: The Molecular Motor KIF21B Mediates Synaptic Plasticity and Fear Extinction by Terminating Rac1 Activation.
KIF21B constrains NBEA dynamics and is present in the NBEA-recycling endosome-NMDA receptor complex.
Title: Neurobeachin and the Kinesin KIF21B Are Critical for Endocytic Recycling of NMDA Receptors and Regulate Social Behavior.
The knockdown of post-mitotic Kif21B resulted in an increase in EPSCs.
Title: Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms.
This study provides insight into the cellular function of KIF21B and the basis for cognitive decline resulting from KIF21B dysregulation.
Title: The Kinesin KIF21B Regulates Microtubule Dynamics and Is Essential for Neuronal Morphology, Synapse Function, and Learning and Memory.
KIF21B participates in the delivery of GABAAR transport vesicles into dendrites.
Title: The kinesin KIF21B participates in the cell surface delivery of γ2 subunit-containing GABAA receptors.
TRIM3, also known as BERP, interacts with KIF21B via its RBCC domain.
Title: TRIM3 regulates the motility of the kinesin motor protein KIF21B.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within corpus callosum development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde dendritic transport	IDA Inferred from Direct Assay more info	PubMed
involved_in retrograde dendritic transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in postsynaptic endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic endosome	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF21B

Names: N-5 kinesin; kinesin-like protein KIF6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039472.2 → NP_001034561.1 kinesin-like protein KIF21B

See identical proteins and their annotated locations for NP_001034561.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the protein-coding transcript.

Source sequence(s)

AC124550

Consensus CDS

CCDS15324.1

UniProtKB/TrEMBL

E9Q0A4, F8VQE2

Related

ENSMUSP00000074661.5, ENSMUST00000075164.11

Conserved Domains (8) summary

smart00129
Location:9 → 378

KISc; Kinesin motor, catalytic domain. ATPase

COG2319
Location:1308 → 1617

WD40; WD40 repeat [General function prediction only]

cd00200
Location:1302 → 1615

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

cd01372
Location:7 → 372

KISc_KIF4; Kinesin motor domain, KIF4-like subfamily

pfam12474
Location:661 → 795

PKK; Polo kinase kinase

pfam16034
Location:679 → 807

JAKMIP_CC3; JAKMIP CC3 domain

sd00039
Location:1314 → 1348

7WD40; WD40 repeat [structural motif]

cl09111
Location:965 → 1101

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...

RNA

NR_153829.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon in the 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC124550

Related

ENSMUST00000130864.9

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

136059128..136105739

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_019962.2: Suppressed sequence

Description

NM_019962.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
NM_177126.2: Suppressed sequence

Description

NM_177126.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.