Obox3 oocyte specific homeobox 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Obox3provided by MGI
Official Full Name: oocyte specific homeobox 3provided by MGI
Primary source: MGI:MGI:2149032
See related: Ensembl:ENSMUSG00000066772 AllianceGenome:MGI:2149032
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ohx
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in maternal-to-zygotic transition of gene expression. Is active in nucleus. Is expressed in 1st branchial arch; brain; early conceptus; and ovary. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: 7 A2; 7 8.53 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (15359231..15373702, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (15625306..15639777, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition.
Title: Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition.

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General gene information

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Markers

Obox3 (e-PCR), detects polymorphism
- UniSTS:547851

NoName (e-PCR)
- UniSTS:487764

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in maternal-to-zygotic transition of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in stem cell population maintenance	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: oocyte-specific homeobox protein 3

Names: oocyte-specific homeobox

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_145707.3 → NP_663753.3 oocyte-specific homeobox protein 3

See identical proteins and their annotated locations for NP_663753.3

Status: VALIDATED

Source sequence(s)

AK139750

Consensus CDS

CCDS20838.1

UniProtKB/Swiss-Prot

D3YXK4, G3UXQ8, G3UXT3, G3UZJ7, Q3UT54, Q8JZN9, Q8VHG6

Related

ENSMUSP00000092842.5, ENSMUST00000095217.11

Conserved Domains (1) summary

cd00086
Location:95 → 153

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.