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    Trpv3 transient receptor potential cation channel, subfamily V, member 3 [ Mus musculus (house mouse) ]

    Gene ID: 246788, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Trpv3provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily V, member 3provided by MGI
    Primary source
    MGI:MGI:2181407
    See related
    Ensembl:ENSMUSG00000043029 AllianceGenome:MGI:2181407
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nh; VRL3; 1110036I10Rik
    Summary
    Enables monoatomic cation channel activity. Acts upstream of or within response to temperature stimulus. Located in membrane. Is expressed in central nervous system and sensory organ. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in colorectal cancer; congenital stationary night blindness; keratosis (multiple); migraine with aura; and schizophrenia. Orthologous to human TRPV3 (transient receptor potential cation channel subfamily V member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 2.4), large intestine adult (RPKM 0.4) and 2 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Trpv3 in Genome Data Viewer
    Location:
    11 B4; 11 45.25 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (73158315..73191194)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (73267489..73300368)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L35a pseudogene Neighboring gene transient receptor potential cation channel, subfamily V, member 1 Neighboring gene STARR-seq mESC enhancer starr_29931 Neighboring gene STARR-seq mESC enhancer starr_29933 Neighboring gene STARR-seq mESC enhancer starr_29936 Neighboring gene aspartoacylase Neighboring gene spermatogenesis associated 22 Neighboring gene olfactory receptor family 1 subfamily E member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Overexpressed transient receptor potential vanilloid 3 ion channels in skin keratinocytes modulate pain sensitivity via prostaglandin E2. Huang SM, et al. J Neurosci, 2008 Dec 17. PMID 19091963, Free PMC Article
    2. Transient Receptor Potential Cation Channel Subfamily Vanilloid 4 and 3 in the Inner Ear Protect Hearing in Mice. Wang S, et al. Front Mol Neurosci, 2019. PMID 31866822, Free PMC Article
    3. Structural basis of temperature sensation by the TRP channel TRPV3. Singh AK, et al. Nat Struct Mol Biol, 2019 Nov. PMID 31636415, Free PMC Article
    4. Inhibition of the Warm Temperature-Activated Ca(2+)-Permeable Transient Receptor Potential Vanilloid TRPV3 Channel Attenuates Atopic Dermatitis. Qu Y, et al. Mol Pharmacol, 2019 Sep. PMID 31308264
    5. Conserved allosteric pathways for activation of TRPV3 revealed through engineering vanilloid-sensitivity. Zhang F, et al. Elife, 2019 Jan 15. PMID 30644819, Free PMC Article

    See all (98) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Aging is associated with impaired triggering of TRPV3-mediated cutaneous vasodilation: a crucial process for local heat exposure.
      Title: Aging is associated with impaired triggering of TRPV3-mediated cutaneous vasodilation: a crucial process for local heat exposure.
    2. TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.
      Title: TRPV3 facilitates lipolysis and attenuates diet-induced obesity via activation of the NRF2/FSP1 signaling axis.
    3. TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne.
      Title: TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne.
    4. Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype.
      Title: Whole genome sequencing analysis of alpaca suggests TRPV3 as a candidate gene for the suri phenotype.
    5. Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.
      Title: Involvement of skin TRPV3 in temperature detection regulated by TMEM79 in mice.
    6. TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence.
      Title: TRPV3 and Itch: The Role of TRPV3 in Chronic Pruritus according to Clinical and Experimental Evidence.
    7. Coassembly of Warm Temperature-Sensitive Transient Receptor Potential Vanilloid (TRPV) 3 and TRPV4 Channel Complexes with Distinct Functional Properties.
      Title: Coassembly of Warm Temperature-Sensitive Transient Receptor Potential Vanilloid (TRPV) 3 and TRPV4 Channel Complexes with Distinct Functional Properties.
    8. TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways.
      Title: TRPV3 enhances skin keratinocyte proliferation through EGFR-dependent signaling pathways.
    9. Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes.
      Title: Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes.
    10. TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01.
      Title: TRPV3 endogenously expressed in murine colonic epithelial cells is inhibited by the novel TRPV3 blocker 26E01.
    Submit: New GeneRIF Correction See all GeneRIFs (55)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124324, MGC124325

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic cation channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables monoatomic ion channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in calcium ion import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of hair cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of hair cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of calcium ion import IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of calcium ion import ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to temperature stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of receptor complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transient receptor potential cation channel subfamily V member 3
    Names
    TRP ion channel TRPV3
    non-hair

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001371006.1 → NP_001357935.1  transient receptor potential cation channel subfamily V member 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL645739, AL663116
      UniProtKB/TrEMBL
      Q32MT9
      Conserved Domains (2) summary
      TIGR00870
      Location:123 → 769
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:214 → 245
      ANK; ANK repeat [structural motif]

    2. NM_145099.3 → NP_659567.2  transient receptor potential cation channel subfamily V member 3 isoform 1

      See identical proteins and their annotated locations for NP_659567.2

      Status: VALIDATED

      Source sequence(s)
      AL645739, AL663116
      Consensus CDS
      CCDS25004.1
      UniProtKB/Swiss-Prot
      Q5SV08, Q8K424
      UniProtKB/TrEMBL
      Q32MT9
      Related
      ENSMUSP00000053755.3, ENSMUST00000049676.3
      Conserved Domains (2) summary
      TIGR00870
      Location:123 → 753
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:214 → 245
      ANK; ANK repeat [structural motif]

    RNA

    1. NR_163834.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL645739, AL663116

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      73158315..73191194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533348.3 → XP_006533411.1  transient receptor potential cation channel subfamily V member 3 isoform X1

      Conserved Domains (2) summary
      TIGR00870
      Location:123 → 517
      trp; transient-receptor-potential calcium channel protein
      sd00045
      Location:214 → 245
      ANK; ANK repeat [structural motif]

    RNA

    1. XR_004936963.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K424.2 GenPept UniProtKB/Swiss-Prot:Q8K424

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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